EA200500253A1 - Способ поиска лекарственного вещества - Google Patents

Способ поиска лекарственного вещества

Info

Publication number
EA200500253A1
EA200500253A1 EA200500253A EA200500253A EA200500253A1 EA 200500253 A1 EA200500253 A1 EA 200500253A1 EA 200500253 A EA200500253 A EA 200500253A EA 200500253 A EA200500253 A EA 200500253A EA 200500253 A1 EA200500253 A1 EA 200500253A1
Authority
EA
Eurasian Patent Office
Prior art keywords
meters
specified
variety
research results
target
Prior art date
Application number
EA200500253A
Other languages
English (en)
Other versions
EA010258B1 (ru
Inventor
Дрор Офер
Original Assignee
Кеддем Байо-Сайенс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кеддем Байо-Сайенс Лтд. filed Critical Кеддем Байо-Сайенс Лтд.
Publication of EA200500253A1 publication Critical patent/EA200500253A1/ru
Publication of EA010258B1 publication Critical patent/EA010258B1/ru

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Evolutionary Biology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Data Mining & Analysis (AREA)
  • Computing Systems (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Способ получения информации о химически активной области молекулы-мишени, например, для поиска лекарственного вещества, включающий предоставление набора, по существу, жестких химических измерителей; осуществление реакции указанной мишени со множеством измерителей указанного набора измерителей; исследование связывания указанных измерителей с указанной мишенью для получения множества результатов исследования и анализ указанных результатов исследования для получения информации об указанной химически активной области.
EA200500253A 2002-07-24 2002-07-24 Способ поиска лекарственного вещества EA010258B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2002/000614 WO2004010136A1 (en) 2002-07-24 2002-07-24 Drug discovery method

Publications (2)

Publication Number Publication Date
EA200500253A1 true EA200500253A1 (ru) 2006-06-30
EA010258B1 EA010258B1 (ru) 2008-06-30

Family

ID=30471435

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500253A EA010258B1 (ru) 2002-07-24 2002-07-24 Способ поиска лекарственного вещества

Country Status (11)

Country Link
US (3) US8019550B2 (ru)
EP (2) EP2581849A1 (ru)
JP (1) JP5166675B2 (ru)
CN (1) CN1668918A (ru)
AU (1) AU2002321793B8 (ru)
BR (2) BRPI0215858B1 (ru)
CA (1) CA2493461C (ru)
EA (1) EA010258B1 (ru)
IL (1) IL166450A0 (ru)
MX (1) MXPA05001038A (ru)
WO (1) WO2004010136A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010258B1 (ru) 2002-07-24 2008-06-30 Кеддем Байо-Сайенс Лтд. Способ поиска лекарственного вещества
DE102004010954A1 (de) 2004-03-03 2005-10-06 Novaled Gmbh Verwendung eines Metallkomplexes als n-Dotand für ein organisches halbleitendes Matrixmaterial, organisches Halbleitermaterial und elektronisches Bauteil
RU2544856C2 (ru) * 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
WO2010020892A2 (en) * 2009-07-07 2010-02-25 The Procter & Gamble Company Property-space similarity modeling
US9218460B2 (en) * 2011-05-09 2015-12-22 The Regents Of The University Of California Defining and mining a joint pharmacophoric space through geometric features
CN102797043B (zh) * 2011-05-23 2015-11-25 天利康（天津）科技有限公司 药物分子片段库及其构建方法
US9747424B2 (en) * 2011-11-18 2017-08-29 Transparency Life Science, Llc Systems and methods for drug development
US20140180660A1 (en) * 2012-12-14 2014-06-26 Life Technologies Holdings Pte Limited Methods and systems for in silico design
EP3128451A1 (en) * 2015-08-07 2017-02-08 Molomics Biotech, S.L. Method, computer program, video game and system for optimizing a molecule for medical applications
KR20190100174A (ko) 2016-12-23 2019-08-28 엑소팜 리미티드 미세소포 및 엑소좀의 정제 또는 단리를 위한 방법 및 조성물
US10430395B2 (en) 2017-03-01 2019-10-01 International Business Machines Corporation Iterative widening search for designing chemical compounds
RU2743316C1 (ru) * 2020-08-14 2021-02-17 Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий Способ идентификации участков связывания белковых комплексов

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US6376524B1 (en) 2000-06-21 2002-04-23 Sunesis Pharmaceuticals, Inc. Triphenyl compounds as interleukin-4 antagonists
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AU2002219920A1 (en) 2000-11-28 2002-06-11 Sunesis Pharmaceuticals, Inc. Salicylate analogs as interleukin-4 antagonists
JP2003133529A (ja) 2001-10-24 2003-05-09 Sony Corp 情報記憶装置およびその製造方法
EA010258B1 (ru) 2002-07-24 2008-06-30 Кеддем Байо-Сайенс Лтд. Способ поиска лекарственного вещества

Also Published As

Publication number Publication date
US9405885B2 (en) 2016-08-02
EA010258B1 (ru) 2008-06-30
CA2493461C (en) 2013-01-08
EP2581849A1 (en) 2013-04-17
AU2002321793B2 (en) 2009-06-18
AU2002321793B8 (en) 2009-07-09
US20050277117A1 (en) 2005-12-15
CA2493461A1 (en) 2004-01-29
AU2002321793A1 (en) 2004-02-09
BR0215858A (pt) 2006-06-06
WO2004010136A1 (en) 2004-01-29
EP1540329A1 (en) 2005-06-15
US20110237458A1 (en) 2011-09-29
JP5166675B2 (ja) 2013-03-21
BRPI0215858B1 (pt) 2020-11-10
MXPA05001038A (es) 2005-09-12
CN1668918A (zh) 2005-09-14
US8019550B2 (en) 2011-09-13
IL166450A0 (en) 2006-01-15
EP1540329A4 (en) 2009-06-10
US20160314241A1 (en) 2016-10-27
JP2006507480A (ja) 2006-03-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU