ATE424010T1 - Betätigungsanzeiger für eine abgabevorrichtung - Google Patents

Betätigungsanzeiger für eine abgabevorrichtung

Info

Publication number
ATE424010T1
ATE424010T1 AT03740282T AT03740282T ATE424010T1 AT E424010 T1 ATE424010 T1 AT E424010T1 AT 03740282 T AT03740282 T AT 03740282T AT 03740282 T AT03740282 T AT 03740282T AT E424010 T1 ATE424010 T1 AT E424010T1
Authority
AT
Austria
Prior art keywords
dispensing device
activation indicator
rotatable element
axle
indicator
Prior art date
Application number
AT03740282T
Other languages
English (en)
Inventor
Stanley George Bonney
Peter John Brand
James William Godfrey
Paul Kenneth Rand
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30001969&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE424010(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0214360A external-priority patent/GB0214360D0/en
Priority claimed from GB0311191A external-priority patent/GB0311191D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE424010T1 publication Critical patent/ATE424010T1/de

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/02—Housing
    • G06M1/028—Arbors, drum fixing and adjusting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0076—Mechanical counters having a display or indicator on a drum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/041—Design features of general application for driving the stage of lowest order for drum-type indicating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Push-Button Switches (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Gas-Filled Discharge Tubes (AREA)
  • Vehicle Body Suspensions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Toys (AREA)
  • Measurement Of Distances Traversed On The Ground (AREA)
  • Formation And Processing Of Food Products (AREA)
AT03740282T 2002-06-21 2003-06-19 Betätigungsanzeiger für eine abgabevorrichtung ATE424010T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0214360A GB0214360D0 (en) 2002-06-21 2002-06-21 Dispenser with doses counter
GB0311191A GB0311191D0 (en) 2003-05-15 2003-05-15 Actuation indicator for dispensing device

Publications (1)

Publication Number Publication Date
ATE424010T1 true ATE424010T1 (de) 2009-03-15

Family

ID=30001969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03740282T ATE424010T1 (de) 2002-06-21 2003-06-19 Betätigungsanzeiger für eine abgabevorrichtung

Country Status (14)

Country Link
US (2) US7500444B2 (de)
EP (2) EP1516283B9 (de)
JP (2) JP4568112B2 (de)
CN (2) CN1662930B (de)
AT (1) ATE424010T1 (de)
BR (1) BRPI0311557B8 (de)
CA (1) CA2489554A1 (de)
CY (2) CY1108995T1 (de)
DE (1) DE60326346D1 (de)
DK (2) DK1516283T3 (de)
ES (2) ES2421402T3 (de)
MX (1) MXPA04012753A (de)
PT (2) PT2058754E (de)
WO (1) WO2004001664A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
AU762744B2 (en) 1999-10-16 2003-07-03 Glaxo Group Limited Device housing for an aerosol container
ATE424010T1 (de) 2002-06-21 2009-03-15 Glaxo Group Ltd Betätigungsanzeiger für eine abgabevorrichtung
GB0226020D0 (en) * 2002-11-07 2002-12-18 Glaxo Group Ltd A holder
GB0301366D0 (en) * 2003-01-21 2003-02-19 Glaxo Group Ltd A fixation device
GB0302812D0 (en) 2003-02-07 2003-03-12 Wickham Mark D Metering valves for dispensers
FR2854878B1 (fr) * 2003-05-15 2006-03-31 Valois Sas Distributeur de produit fluide.
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
NZ548888A (en) * 2004-02-16 2010-06-25 Glaxo Group Ltd Counter for use with a medicament dispenser
US20050194400A1 (en) * 2004-03-05 2005-09-08 Berube Patricia J. Children's nasal spray containers and inhalers
ES2936138T3 (es) * 2004-03-10 2023-03-14 Glaxo Group Ltd Un dispositivo dispensador
DE202004007115U1 (de) * 2004-05-03 2004-07-08 Altana Pharma Ag Blindungsvorrichtung
GB2414187B (en) * 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
SE0401773D0 (sv) 2004-07-02 2004-07-02 Astrazeneca Ab An inhalation and a method for assemnling said inhalation device
SE0401786D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Inhaler device
GB2417024B (en) * 2004-08-11 2007-01-03 Bespak Plc Improvements in metering valves for dispensers
GB0518400D0 (en) * 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
GB0602049D0 (en) * 2006-02-01 2006-03-15 Trumeter Company Ltd Inhaler
US9107798B2 (en) * 2006-03-09 2015-08-18 Slender Medical Ltd. Method and system for lipolysis and body contouring
GB0605150D0 (en) * 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
WO2007124406A2 (en) 2006-04-21 2007-11-01 3M Innovative Properties Company Dose counter
GB2438396B (en) * 2006-05-26 2008-10-01 Bespak Plc Improvements in or relating to dispensing apparatus
GB0610541D0 (en) 2006-05-26 2006-07-05 Bespak Plc Improvements in or relating to dispensing apparatus
GB0613472D0 (en) * 2006-07-06 2006-08-16 Glaxo Group Ltd A counter and a recorder for a pill dispenser
US8141550B2 (en) * 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
JP5632284B2 (ja) * 2007-08-07 2014-11-26 エーセルアールエックス ファーマシューティカルズ， インコーポレイテッド 経口経粘膜剤形を使用する処置時の鎮静および無痛のための組成物および方法
BRPI0817327A2 (pt) * 2007-09-26 2015-03-24 Otsuka Pharma Co Ltd Inalador de dose medida
US8251876B2 (en) 2008-04-22 2012-08-28 Hill-Rom Services, Inc. Breathing exercise apparatus
WO2010029555A1 (en) * 2008-09-12 2010-03-18 Slender Medical, Ltd. Virtual ultrasonic scissors
ES2402241T3 (es) * 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US7993609B2 (en) * 2008-12-30 2011-08-09 Sterilucent, Inc. Package for chemicals
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
JP5539513B2 (ja) 2009-07-30 2014-07-02 アイバックス インターナショナル ベスローテン ベンノートシャップ 計量式吸入器のための用量カウンタ、計量式吸入器、および用量をカウントする方法
CN102497903B (zh) 2009-07-30 2015-09-16 伊瓦克国际有限责任公司 用于定量吸入器的剂量计数器
CN102497902B (zh) 2009-07-30 2014-11-05 伊瓦克国际有限责任公司 定量吸入器的剂量计数器
GB0921555D0 (en) * 2009-12-09 2010-01-27 3M Innovative Properties Co Dose indicator
US20110184322A1 (en) * 2010-01-22 2011-07-28 Slender Medical Ltd. Method and device for treatment of keloids and hypertrophic scars using focused ultrasound
AU2013231214B2 (en) * 2010-05-18 2015-12-17 Ivax Pharmaceuticals Ireland Dose counters for inhalers, inhalers and shafts thereof
CN105903108A (zh) * 2010-05-18 2016-08-31 艾瓦克斯医药爱尔兰公司 用于吸入器的剂量计数器、吸入器及其轴
EP2514466B1 (de) * 2010-05-18 2015-07-01 Ivax Pharmaceuticals Ireland Inhalator mit Dosiszählwerk und Verfahren zur Montage eines Inhalators
FR2961186B1 (fr) * 2010-06-11 2012-07-13 Valois Sas Dispositif de distribution de produit fluide.
EP2582468B1 (de) * 2010-06-18 2016-10-19 Boehringer Ingelheim International GmbH Inhalator
US20130338545A1 (en) * 2010-12-14 2013-12-19 Slender Medical Ltd. Ultrasound skin treatment
GB201118845D0 (en) 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser
HK1198954A1 (en) * 2012-01-23 2015-06-19 Sanofi Sa Dose counting mechanism for an inhalation device and inhalation device
US20150306322A9 (en) * 2012-01-23 2015-10-29 Sanofi Sa Inhalation Device
US9180271B2 (en) 2012-03-05 2015-11-10 Hill-Rom Services Pte. Ltd. Respiratory therapy device having standard and oscillatory PEP with nebulizer
EP2845148A1 (de) * 2012-05-04 2015-03-11 Sanofi SA Zählmechanismus für eine wirkstofffreisetzungsvorrichtung und wirkstofffreisetzungsvorrichtung
GB201223008D0 (en) * 2012-12-20 2013-01-30 Euro Celtique Sa Counter
DE102014114462A1 (de) * 2013-10-15 2015-04-16 Alfred Von Schuckmann Zählwerk und Handgerät mit Zählwerk
GB201401659D0 (en) * 2014-01-31 2014-03-19 3M Innovative Properties Co Actuator for an inhaler
US20150297308A1 (en) * 2014-04-18 2015-10-22 Enterogauge, Llc Enteroscope measuring device
EP3139984B1 (de) 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Zerstäuber
AU2015257878B2 (en) * 2014-05-07 2019-08-08 Boehringer Ingelheim International Gmbh Container, nebulizer and use
NZ732808A (en) 2014-12-23 2021-12-24 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
CN107420619B (zh) * 2017-09-14 2023-01-17 东莞力嘉塑料制品有限公司 一种无源机械循环式压力释放执行装置
US11291182B2 (en) * 2018-02-05 2022-04-05 Nexfeed LLP Device for facilitating and tracking the feeding of an animal
EP3763406A1 (de) * 2019-07-12 2021-01-13 Sanofi Verfahren und elektronische vorrichtung zum erfassen von lieferinformationen
GB201911576D0 (en) * 2019-08-13 2019-09-25 Coalesce Product Dev Ltd Dose counting mechanism
CN117205413B (zh) * 2023-11-07 2024-02-13 正大天晴(广州)医药有限公司 一种剂量指示装置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH508198A (de) * 1969-03-25 1971-05-31 Gneupel Arthur Praez Smechanik Längenmessgerät mit Schieber, welcher ein Zählwerk zur unmittelbaren Anzeige und Ablesung der Messwerte aufweist
JPS5940602Y2 (ja) * 1976-06-30 1984-11-19 オリンパス光学工業株式会社 精密機器の摺動装置
JPS57103585A (en) * 1980-12-19 1982-06-28 Tamura Electric Works Ltd Counter
JPS5991591A (ja) * 1982-11-18 1984-05-26 Tamura Electric Works Ltd カウンタ
AU598250B2 (en) 1986-04-25 1990-06-21 Glaxo Group Limited Indicating device
JP2896425B2 (ja) * 1988-08-26 1999-05-31 株式会社日立製作所 カード状媒体処理装置および現金取扱い装置並びにカード状媒体
IT221659Z2 (it) * 1989-10-20 1994-07-25 Veglia Borletti Srl Dispositivo di allineamento delle cifre di un numeratore totalizzatorea tamburi numerati di visualizzazione.
JPH06152159A (ja) * 1992-10-30 1994-05-31 Polyplastics Co 蓋体の連結具
US5482030A (en) 1994-06-13 1996-01-09 Klein; David Aerosol and non-aerosol spray counter
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
JPH10293830A (ja) * 1997-04-18 1998-11-04 Ricoh Elemex Corp 計量器用数字車式表示装置
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
US6067927A (en) * 1997-09-30 2000-05-30 Johnson; Lenard W. Visual indicator
JPH11125501A (ja) * 1997-10-22 1999-05-11 Nippon Steel Corp 累積変位計
DE69918267T2 (de) * 1998-01-16 2005-07-28 1263152 Ontario Inc., London Anzeigevorrichtung zur verwendung mit einer abgabevorrichtung
GB9917892D0 (en) 1999-07-31 1999-09-29 Glaxo Group Ltd Marking method
AU762744B2 (en) 1999-10-16 2003-07-03 Glaxo Group Limited Device housing for an aerosol container
ATE424010T1 (de) * 2002-06-21 2009-03-15 Glaxo Group Ltd Betätigungsanzeiger für eine abgabevorrichtung

Also Published As

Publication number Publication date
JP5107976B2 (ja) 2012-12-26
BR0311557A (pt) 2005-04-26
PT2058754E (pt) 2013-07-24
JP4568112B2 (ja) 2010-10-27
MXPA04012753A (es) 2005-08-15
EP1516283B1 (de) 2009-02-25
CN101853424A (zh) 2010-10-06
CY1108995T1 (el) 2014-07-02
CN1662930A (zh) 2005-08-31
HK1075955A1 (en) 2005-12-30
BRPI0311557B1 (pt) 2020-07-28
JP2009273899A (ja) 2009-11-26
ES2321601T3 (es) 2009-06-09
EP2058754A1 (de) 2009-05-13
CA2489554A1 (en) 2003-12-31
AU2003278236A1 (en) 2004-01-06
US7500444B2 (en) 2009-03-10
JP2005530259A (ja) 2005-10-06
CY1114371T1 (el) 2016-08-31
DE60326346D1 (de) 2009-04-09
ES2421402T3 (es) 2013-09-02
EP1516283B9 (de) 2009-10-07
BRPI0311557B8 (pt) 2021-07-27
DK2058754T3 (da) 2013-07-22
HK1127143A1 (en) 2009-09-18
EP2058754B1 (de) 2013-05-01
CN101853424B (zh) 2015-05-06
US20090178673A1 (en) 2009-07-16
PT1516283E (pt) 2009-05-11
CN1662930B (zh) 2010-10-27
WO2004001664A1 (en) 2003-12-31
DK1516283T3 (da) 2009-06-15
US7832351B2 (en) 2010-11-16
US20060096594A1 (en) 2006-05-11
EP1516283A1 (de) 2005-03-23

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