ATE421594T1 - Vorrichtung für die analyse der elektrophysiologie von neuronalen zellen und ihre verwendung in hochdurchsatzverfahren zur funktionellen genanalyse - Google Patents

Vorrichtung für die analyse der elektrophysiologie von neuronalen zellen und ihre verwendung in hochdurchsatzverfahren zur funktionellen genanalyse

Info

Publication number
ATE421594T1
ATE421594T1 AT00936147T AT00936147T ATE421594T1 AT E421594 T1 ATE421594 T1 AT E421594T1 AT 00936147 T AT00936147 T AT 00936147T AT 00936147 T AT00936147 T AT 00936147T AT E421594 T1 ATE421594 T1 AT E421594T1
Authority
AT
Austria
Prior art keywords
electrophysiology
analysis
action
action potential
cell
Prior art date
Application number
AT00936147T
Other languages
English (en)
Inventor
James J Hickman
Original Assignee
James J Hickman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James J Hickman filed Critical James J Hickman
Application granted granted Critical
Publication of ATE421594T1 publication Critical patent/ATE421594T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00936147T 1999-05-21 2000-05-22 Vorrichtung für die analyse der elektrophysiologie von neuronalen zellen und ihre verwendung in hochdurchsatzverfahren zur funktionellen genanalyse ATE421594T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13527599P 1999-05-21 1999-05-21

Publications (1)

Publication Number Publication Date
ATE421594T1 true ATE421594T1 (de) 2009-02-15

Family

ID=22467354

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00936147T ATE421594T1 (de) 1999-05-21 2000-05-22 Vorrichtung für die analyse der elektrophysiologie von neuronalen zellen und ihre verwendung in hochdurchsatzverfahren zur funktionellen genanalyse

Country Status (7)

Country Link
EP (1) EP1180162B1 (de)
JP (1) JP2003500065A (de)
AT (1) ATE421594T1 (de)
AU (1) AU780409B2 (de)
CA (1) CA2374436A1 (de)
DE (1) DE60041443D1 (de)
WO (1) WO2000071742A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7266457B1 (en) 1999-05-21 2007-09-04 Hesperos, Llc High throughput functional genomics
WO2002004943A2 (en) * 2000-07-07 2002-01-17 Bristol-Myers Squibb Company Electrophysiology configuration suitable for high throughput screening of compounds for drug discovery
US20060029955A1 (en) 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
WO2002077259A2 (en) 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US20030091980A1 (en) * 2001-10-12 2003-05-15 Gary Lynch Detection and characterization of psychoactives using analysis of network level physiological responses in a neuronal sample
JP2005511039A (ja) 2001-11-30 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー 自動パッチクランプ記録用液体界面形態
EP1495105B1 (de) * 2002-04-17 2007-02-21 Sophion Bioscience A/S Substrat und verfahren zum messen elektrophysiologischer eigenschaften von zellmembranen
GB2398635A (en) 2003-02-21 2004-08-25 Sophion Bioscience As A substrate providing a cell gigaseal for a patch clamp
EP1501924A4 (de) 2002-05-04 2006-05-24 Aviva Biosciences Corp Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren
WO2004001426A2 (en) * 2002-06-20 2003-12-31 Axonyx, Inc. Method for identifying drugs for the treatment of alzheimer's disease
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
GB0307352D0 (en) * 2003-03-29 2003-05-07 Qinetiq Ltd Improvements in and relating to the analysis of compounds
DE10323096A1 (de) * 2003-05-16 2004-12-09 Siemens Ag Verfahren zur Untersuchung eines Wirkstoffeinflusses auf biologische Zellen
KR20070115929A (ko) * 2005-03-22 2007-12-06 가부시키가이샤 메디넷 세포배양 평가시스템, 세포배양 평가방법 및 세포배양평가프로그램
WO2007137589A1 (en) * 2006-05-30 2007-12-06 Syddansk Universitet Determination of action currents in excitable cells
CA2776501C (en) * 2009-10-02 2022-04-19 Blanchette Rockefeller Neurosciences Institute Fibroblast growth patterns for diagnosis of alzheimer's disease
WO2012027218A2 (en) 2010-08-27 2012-03-01 Corning Incorporated Peptide-modified surfaces for cell culture
JP5723604B2 (ja) * 2011-01-13 2015-05-27 株式会社日立製作所 神経活動計測装置及びその方法
US20140206028A1 (en) * 2011-05-17 2014-07-24 University Of Central Florida Research Foundation, Inc. Stable Electrically Active Neurons from Adult Tissue
JP2014520568A (ja) * 2011-07-20 2014-08-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ナノ細孔ポリヌクレオチド配列決定、その他の用途のための補償型パッチクランプ増幅器
CA2932867C (en) 2013-12-20 2022-06-21 Alcoa Inc. High performance alsimgcu casting alloy
CN113345042B (zh) * 2021-05-31 2022-07-22 太原理工大学 一种基于改进果蝇优化算法的ect图像重建方法
CN113789263A (zh) * 2021-08-30 2021-12-14 东南大学 一种用于体外神经细胞网络多参数实时监测的多通道系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563067A (en) * 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
CN1183121A (zh) * 1996-01-24 1998-05-27 松下电器产业株式会社 测定组织或细胞物理化学特性的方法、检测药品的方法及其装置
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors

Also Published As

Publication number Publication date
CA2374436A1 (en) 2000-11-30
WO2000071742A3 (en) 2001-08-23
JP2003500065A (ja) 2003-01-07
WO2000071742A2 (en) 2000-11-30
DE60041443D1 (de) 2009-03-12
EP1180162B1 (de) 2009-01-21
AU780409B2 (en) 2005-03-17
EP1180162A2 (de) 2002-02-20
WO2000071742A9 (en) 2002-04-18
AU5150800A (en) 2000-12-12

Similar Documents

Publication Publication Date Title
ATE421594T1 (de) Vorrichtung für die analyse der elektrophysiologie von neuronalen zellen und ihre verwendung in hochdurchsatzverfahren zur funktionellen genanalyse
Collins et al. High throughput toxicity screening and intracellular detection of nanomaterials
Huang et al. Single-cell assay on microfluidic devices
US9194841B2 (en) Devices and processes for analyzing nucleic acid damage and repair using electrophoresis
DE69832381T2 (de) Nachweis biologisch aktiver moleküle durch verwendung von voraktivierten zellgestützten biosensoren in trennsystemen auf flüssigkeitsgrundlage
McNally et al. Electromechanical unzipping of individual DNA molecules using synthetic sub-2 nm pores
DE60208313T2 (de) Mikroelektronischer Detektor auf einem Chip
Wei et al. An implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in vivo
US20070238112A1 (en) Microfluidic and nanofluidic electronic devices for detecting changes in capacitance of fluids and methods of using
DE69931497D1 (de) Gel mikrotropfen für die genetische analyse
Teng et al. Electrodeformation-based biomechanical chip for quantifying global viscoelasticity of cancer cells regulated by cell cycle
US7236888B2 (en) Method to measure the activation state of signaling pathways in cells
Amatore et al. Vesicular exocytosis and microdevices–microelectrode arrays
Honrado et al. Label-free quantification of cell cycle synchronicity of human neural progenitor cells based on electrophysiology phenotypes
Keighron et al. Electrochemistry of single-vesicle events
JPWO2005116242A1 (ja) 医薬品安全性試験方法及び医薬品安全性試験システム
Wolf et al. Cellular signaling: aspects for tumor diagnosis and therapy
Obien et al. CMOS-based high-density microelectrode arrays: technology and applications
EP1336101B1 (de) Verfahren zur messung des aktivierungszustands von signalwegen in zellen
AT505106A1 (de) Einrichtung, insbesondere bio-chip, zur identifizierung von mikro-organismen
EP2064546B1 (de) Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit
EP1255982B1 (de) Messverfahren unter einsatz mindestens einer biologischen rezeptorzelle sowie eine zur durchführung des messverfahrens geeignete vorrichtung
Xu et al. Cell-based biosensors: Towards the development of cellular monitoring
Yamamoto et al. Microfluidic technologies for reconstituting neuronal network functions in vitro
Egert Network on chips

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties