ATE420073T1 - Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere - Google Patents
Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomereInfo
- Publication number
- ATE420073T1 ATE420073T1 AT05077084T AT05077084T ATE420073T1 AT E420073 T1 ATE420073 T1 AT E420073T1 AT 05077084 T AT05077084 T AT 05077084T AT 05077084 T AT05077084 T AT 05077084T AT E420073 T1 ATE420073 T1 AT E420073T1
- Authority
- AT
- Austria
- Prior art keywords
- erythro
- stereoisomers
- carbon atoms
- threo
- reacting
- Prior art date
Links
- DWKUKQRKVCMOLP-UHFFFAOYSA-N 1-piperideine Chemical class C1CCN=CC1 DWKUKQRKVCMOLP-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 8
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal alkoxide Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005233 alkylalcohol group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/792,661 US5965734A (en) | 1997-01-31 | 1997-01-31 | Processes and intermediates for preparing 2-substituted piperidine stereoisomers |
| PCT/US1998/010599 WO1999061425A1 (en) | 1997-01-31 | 1998-05-26 | Processes and intermediates for preparing 2-substituted piperidine stereoisomers |
| EP98923727A EP1082307B1 (en) | 1997-01-31 | 1998-05-26 | Processes and intermediates for preparing 2-substituted piperidine stereoisomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE420073T1 true ATE420073T1 (de) | 2009-01-15 |
Family
ID=26794135
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05077084T ATE420073T1 (de) | 1997-01-31 | 1998-05-26 | Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere |
| AT98923727T ATE304531T1 (de) | 1997-01-31 | 1998-05-26 | Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidin-stereoisomere |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98923727T ATE304531T1 (de) | 1997-01-31 | 1998-05-26 | Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidin-stereoisomere |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5965734A (enExample) |
| EP (2) | EP1612207B1 (enExample) |
| JP (1) | JP4491135B2 (enExample) |
| AT (2) | ATE420073T1 (enExample) |
| AU (1) | AU765194B2 (enExample) |
| CA (1) | CA2333089C (enExample) |
| CY (1) | CY1108818T1 (enExample) |
| DE (2) | DE69840457D1 (enExample) |
| DK (2) | DK1612207T3 (enExample) |
| ES (2) | ES2249830T3 (enExample) |
| PT (1) | PT1612207E (enExample) |
| WO (1) | WO1999061425A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US6359139B1 (en) * | 2000-11-07 | 2002-03-19 | Celgene Corporation | Methods for production of piperidyl acetamide stereoisomers |
| US20020187192A1 (en) * | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
| US20030073681A1 (en) * | 2001-08-21 | 2003-04-17 | Hauske James R. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
| US6638533B2 (en) | 2002-01-03 | 2003-10-28 | George Krsek | Pulse dosage formulations of methylphenidate and method to prepare same |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| CN101076248A (zh) * | 2004-12-09 | 2007-11-21 | 塞尔基因公司 | 使用d－苏型哌甲酯的治疗 |
| ITMI20042415A1 (it) * | 2004-12-17 | 2005-03-17 | Clariant Lsm Italia Spa | Sintesi di alfa-aril-alfa-piperid-2-il-acetammidi e loro idrolisi acida |
| US9233924B2 (en) | 2014-03-11 | 2016-01-12 | Ampac Fine Chemicals Llc | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507631A (en) * | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
| US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
| JPS5630978A (en) * | 1979-08-24 | 1981-03-28 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin and its preparation |
| US4978744A (en) * | 1989-01-27 | 1990-12-18 | Arizona Board Of Regents | Synthesis of dolastatin 10 |
| US5075315A (en) * | 1990-05-17 | 1991-12-24 | Mcneilab, Inc. | Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives |
| EP0637308A1 (en) * | 1992-03-16 | 1995-02-08 | MERCK SHARP & DOHME LTD. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| PT730581E (pt) * | 1993-11-22 | 2002-02-28 | Merck & Co Inc | 3-acilaminobenzazepinas |
| ES2144183T3 (es) * | 1995-10-30 | 2000-06-01 | Hoffmann La Roche | 1-alfa,26-dihidroxi-d-homo-vitamina d3. |
| DE19615119A1 (de) * | 1996-04-17 | 1997-10-23 | Bayer Ag | Neue Arylessigsäureamide |
-
1997
- 1997-01-31 US US08/792,661 patent/US5965734A/en not_active Expired - Lifetime
-
1998
- 1998-05-26 ES ES98923727T patent/ES2249830T3/es not_active Expired - Lifetime
- 1998-05-26 DK DK05077084T patent/DK1612207T3/da active
- 1998-05-26 AU AU75950/98A patent/AU765194B2/en not_active Expired
- 1998-05-26 WO PCT/US1998/010599 patent/WO1999061425A1/en not_active Ceased
- 1998-05-26 AT AT05077084T patent/ATE420073T1/de active
- 1998-05-26 DK DK98923727T patent/DK1082307T3/da active
- 1998-05-26 CA CA002333089A patent/CA2333089C/en not_active Expired - Lifetime
- 1998-05-26 ES ES05077084T patent/ES2320012T3/es not_active Expired - Lifetime
- 1998-05-26 EP EP05077084A patent/EP1612207B1/en not_active Expired - Lifetime
- 1998-05-26 DE DE69840457T patent/DE69840457D1/de not_active Expired - Lifetime
- 1998-05-26 JP JP2000550831A patent/JP4491135B2/ja not_active Expired - Fee Related
- 1998-05-26 PT PT05077084T patent/PT1612207E/pt unknown
- 1998-05-26 AT AT98923727T patent/ATE304531T1/de active
- 1998-05-26 DE DE69831611T patent/DE69831611T2/de not_active Expired - Lifetime
- 1998-05-26 EP EP98923727A patent/EP1082307B1/en not_active Expired - Lifetime
-
2009
- 2009-02-26 CY CY20091100223T patent/CY1108818T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69831611D1 (de) | 2005-10-20 |
| DK1082307T3 (da) | 2005-12-19 |
| CA2333089C (en) | 2008-10-14 |
| PT1612207E (pt) | 2009-02-04 |
| HK1090915A1 (en) | 2007-01-05 |
| DE69840457D1 (de) | 2009-02-26 |
| EP1612207A1 (en) | 2006-01-04 |
| EP1082307A4 (en) | 2004-04-14 |
| CY1108818T1 (el) | 2014-04-09 |
| ES2249830T3 (es) | 2006-04-01 |
| AU765194B2 (en) | 2003-09-11 |
| ATE304531T1 (de) | 2005-09-15 |
| EP1082307B1 (en) | 2005-09-14 |
| JP2002516313A (ja) | 2002-06-04 |
| CA2333089A1 (en) | 1999-12-02 |
| JP4491135B2 (ja) | 2010-06-30 |
| DK1612207T3 (da) | 2009-05-04 |
| US5965734A (en) | 1999-10-12 |
| DE69831611T2 (de) | 2006-06-14 |
| AU7595098A (en) | 1999-12-13 |
| WO1999061425A1 (en) | 1999-12-02 |
| EP1612207B1 (en) | 2009-01-07 |
| ES2320012T3 (es) | 2009-05-18 |
| EP1082307A1 (en) | 2001-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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