JP4491135B2 - ２−置換ピペリジン立体異性体を製造するための方法及び中間体 - Google Patents

２−置換ピペリジン立体異性体を製造するための方法及び中間体 Download PDF

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Publication number
JP4491135B2
JP4491135B2 JP2000550831A JP2000550831A JP4491135B2 JP 4491135 B2 JP4491135 B2 JP 4491135B2 JP 2000550831 A JP2000550831 A JP 2000550831A JP 2000550831 A JP2000550831 A JP 2000550831A JP 4491135 B2 JP4491135 B2 JP 4491135B2
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JP
Japan
Prior art keywords
erythro
carbon atoms
salt
threo
stereoisomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2000550831A
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English (en)
Japanese (ja)
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JP2002516313A (ja
JP2002516313A5 (enExample
Inventor
ラマスワミ，ソウミアナラヤナン
ケタニ，ビクラム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
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Publication date
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Publication of JP2002516313A publication Critical patent/JP2002516313A/ja
Publication of JP2002516313A5 publication Critical patent/JP2002516313A5/ja
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Publication of JP4491135B2 publication Critical patent/JP4491135B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000550831A 1997-01-31 1998-05-26 ２−置換ピペリジン立体異性体を製造するための方法及び中間体 Expired - Fee Related JP4491135B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/792,661 US5965734A (en) 1997-01-31 1997-01-31 Processes and intermediates for preparing 2-substituted piperidine stereoisomers
PCT/US1998/010599 WO1999061425A1 (en) 1997-01-31 1998-05-26 Processes and intermediates for preparing 2-substituted piperidine stereoisomers

Publications (3)

Publication Number Publication Date
JP2002516313A JP2002516313A (ja) 2002-06-04
JP2002516313A5 JP2002516313A5 (enExample) 2006-01-05
JP4491135B2 true JP4491135B2 (ja) 2010-06-30

Family

ID=26794135

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000550831A Expired - Fee Related JP4491135B2 (ja) 1997-01-31 1998-05-26 ２−置換ピペリジン立体異性体を製造するための方法及び中間体

Country Status (12)

Country Link
US (1) US5965734A (enExample)
EP (2) EP1082307B1 (enExample)
JP (1) JP4491135B2 (enExample)
AT (2) ATE304531T1 (enExample)
AU (1) AU765194B2 (enExample)
CA (1) CA2333089C (enExample)
CY (1) CY1108818T1 (enExample)
DE (2) DE69831611T2 (enExample)
DK (2) DK1082307T3 (enExample)
ES (2) ES2320012T3 (enExample)
PT (1) PT1612207E (enExample)
WO (1) WO1999061425A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6359139B1 (en) * 2000-11-07 2002-03-19 Celgene Corporation Methods for production of piperidyl acetamide stereoisomers
US20020187192A1 (en) * 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US20030073681A1 (en) * 2001-08-21 2003-04-17 Hauske James R. 2-substituted piperidines that are ligands for monoamine receptors and transporters
US6638533B2 (en) 2002-01-03 2003-10-28 George Krsek Pulse dosage formulations of methylphenidate and method to prepare same
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
CA2591247A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment of patients suffering from a disease having a family history or diagnosis of tics or tourette's syndrome with d-threo methylphenidate
ITMI20042415A1 (it) * 2004-12-17 2005-03-17 Clariant Lsm Italia Spa Sintesi di alfa-aril-alfa-piperid-2-il-acetammidi e loro idrolisi acida
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5075315A (en) * 1990-05-17 1991-12-24 Mcneilab, Inc. Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
WO1993019063A1 (en) * 1992-03-16 1993-09-30 Merck Sharp & Dohme Limited Benzodiazepine derivatives, compositions containing them and their use in therapy
US5696111A (en) * 1993-11-22 1997-12-09 Merck & Co., Inc. 3-acylaminobenzazepines
EP0771789B1 (en) * 1995-10-30 2000-02-16 F. Hoffmann-La Roche Ag 1 alpha, 26-dihydroxy-D-homo-vitamin D3
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
EP1082307A4 (en) 2004-04-14
ATE304531T1 (de) 2005-09-15
PT1612207E (pt) 2009-02-04
EP1612207B1 (en) 2009-01-07
WO1999061425A1 (en) 1999-12-02
ES2320012T3 (es) 2009-05-18
HK1090915A1 (en) 2007-01-05
AU765194B2 (en) 2003-09-11
EP1082307B1 (en) 2005-09-14
JP2002516313A (ja) 2002-06-04
AU7595098A (en) 1999-12-13
DE69831611T2 (de) 2006-06-14
EP1082307A1 (en) 2001-03-14
CA2333089C (en) 2008-10-14
DE69831611D1 (de) 2005-10-20
CA2333089A1 (en) 1999-12-02
US5965734A (en) 1999-10-12
EP1612207A1 (en) 2006-01-04
DK1612207T3 (da) 2009-05-04
ES2249830T3 (es) 2006-04-01
ATE420073T1 (de) 2009-01-15
DE69840457D1 (de) 2009-02-26
CY1108818T1 (el) 2014-04-09
DK1082307T3 (da) 2005-12-19

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