JP2002516313A5 - - Google Patents
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- Publication number
- JP2002516313A5 JP2002516313A5 JP2000550831A JP2000550831A JP2002516313A5 JP 2002516313 A5 JP2002516313 A5 JP 2002516313A5 JP 2000550831 A JP2000550831 A JP 2000550831A JP 2000550831 A JP2000550831 A JP 2000550831A JP 2002516313 A5 JP2002516313 A5 JP 2002516313A5
- Authority
- JP
- Japan
- Prior art keywords
- erythro
- carbon atoms
- formula
- embedded image
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 12
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- 239000002253 acid Substances 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 6
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 0 *C(*)[C@@]1NCCCC1 Chemical compound *C(*)[C@@]1NCCCC1 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- -1 alkali metal alkoxide Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 125000005233 alkylalcohol group Chemical group 0.000 description 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
- AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/792,661 US5965734A (en) | 1997-01-31 | 1997-01-31 | Processes and intermediates for preparing 2-substituted piperidine stereoisomers |
| PCT/US1998/010599 WO1999061425A1 (en) | 1997-01-31 | 1998-05-26 | Processes and intermediates for preparing 2-substituted piperidine stereoisomers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002516313A JP2002516313A (ja) | 2002-06-04 |
| JP2002516313A5 true JP2002516313A5 (enExample) | 2006-01-05 |
| JP4491135B2 JP4491135B2 (ja) | 2010-06-30 |
Family
ID=26794135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000550831A Expired - Fee Related JP4491135B2 (ja) | 1997-01-31 | 1998-05-26 | ２−置換ピペリジン立体異性体を製造するための方法及び中間体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5965734A (enExample) |
| EP (2) | EP1612207B1 (enExample) |
| JP (1) | JP4491135B2 (enExample) |
| AT (2) | ATE304531T1 (enExample) |
| AU (1) | AU765194B2 (enExample) |
| CA (1) | CA2333089C (enExample) |
| CY (1) | CY1108818T1 (enExample) |
| DE (2) | DE69831611T2 (enExample) |
| DK (2) | DK1612207T3 (enExample) |
| ES (2) | ES2320012T3 (enExample) |
| PT (1) | PT1612207E (enExample) |
| WO (1) | WO1999061425A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US6359139B1 (en) * | 2000-11-07 | 2002-03-19 | Celgene Corporation | Methods for production of piperidyl acetamide stereoisomers |
| US20020187192A1 (en) * | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
| AU2002332659A1 (en) * | 2001-08-21 | 2003-03-03 | Sepracor, Inc. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
| US6638533B2 (en) | 2002-01-03 | 2003-10-28 | George Krsek | Pulse dosage formulations of methylphenidate and method to prepare same |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| CA2591247A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment of patients suffering from a disease having a family history or diagnosis of tics or tourette's syndrome with d-threo methylphenidate |
| ITMI20042415A1 (it) * | 2004-12-17 | 2005-03-17 | Clariant Lsm Italia Spa | Sintesi di alfa-aril-alfa-piperid-2-il-acetammidi e loro idrolisi acida |
| US9233924B2 (en) | 2014-03-11 | 2016-01-12 | Ampac Fine Chemicals Llc | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507631A (en) * | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
| US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
| JPS5630978A (en) * | 1979-08-24 | 1981-03-28 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin and its preparation |
| US4978744A (en) * | 1989-01-27 | 1990-12-18 | Arizona Board Of Regents | Synthesis of dolastatin 10 |
| US5075315A (en) * | 1990-05-17 | 1991-12-24 | Mcneilab, Inc. | Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives |
| AU670939B2 (en) * | 1992-03-16 | 1996-08-08 | Merck Sharp & Dohme Limited | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| AU681924B2 (en) * | 1993-11-22 | 1997-09-11 | Merck & Co., Inc. | 3-acylaminobenzazepines |
| PT771789E (pt) * | 1995-10-30 | 2000-05-31 | Hoffmann La Roche | 1 alfa 26-di-hidroxi-d-homo-vitamina d3 |
| DE19615119A1 (de) * | 1996-04-17 | 1997-10-23 | Bayer Ag | Neue Arylessigsäureamide |
-
1997
- 1997-01-31 US US08/792,661 patent/US5965734A/en not_active Expired - Lifetime
-
1998
- 1998-05-26 AT AT98923727T patent/ATE304531T1/de active
- 1998-05-26 DE DE69831611T patent/DE69831611T2/de not_active Expired - Lifetime
- 1998-05-26 DK DK05077084T patent/DK1612207T3/da active
- 1998-05-26 WO PCT/US1998/010599 patent/WO1999061425A1/en not_active Ceased
- 1998-05-26 EP EP05077084A patent/EP1612207B1/en not_active Expired - Lifetime
- 1998-05-26 AT AT05077084T patent/ATE420073T1/de active
- 1998-05-26 CA CA002333089A patent/CA2333089C/en not_active Expired - Lifetime
- 1998-05-26 ES ES05077084T patent/ES2320012T3/es not_active Expired - Lifetime
- 1998-05-26 PT PT05077084T patent/PT1612207E/pt unknown
- 1998-05-26 DE DE69840457T patent/DE69840457D1/de not_active Expired - Lifetime
- 1998-05-26 DK DK98923727T patent/DK1082307T3/da active
- 1998-05-26 AU AU75950/98A patent/AU765194B2/en not_active Expired
- 1998-05-26 JP JP2000550831A patent/JP4491135B2/ja not_active Expired - Fee Related
- 1998-05-26 ES ES98923727T patent/ES2249830T3/es not_active Expired - Lifetime
- 1998-05-26 EP EP98923727A patent/EP1082307B1/en not_active Expired - Lifetime
-
2009
- 2009-02-26 CY CY20091100223T patent/CY1108818T1/el unknown
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