ATE418085T1 - Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung - Google Patents

Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung

Info

Publication number
ATE418085T1
ATE418085T1 AT06710202T AT06710202T ATE418085T1 AT E418085 T1 ATE418085 T1 AT E418085T1 AT 06710202 T AT06710202 T AT 06710202T AT 06710202 T AT06710202 T AT 06710202T AT E418085 T1 ATE418085 T1 AT E418085T1
Authority
AT
Austria
Prior art keywords
examining
optical
optical signal
time
light source
Prior art date
Application number
AT06710202T
Other languages
English (en)
Inventor
Pal Maak
Julia Fekete
Laszlo Valenta
Gergely Katona
Peter Kallo
Karoly Osvay
E Szilveszter Vizi
Robert Szipocs
Balazs Rozsa
Original Assignee
E Szilveszter Vizi
Szipoecs Robert
Balazs Rozsa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Szilveszter Vizi, Szipoecs Robert, Balazs Rozsa filed Critical E Szilveszter Vizi
Application granted granted Critical
Publication of ATE418085T1 publication Critical patent/ATE418085T1/de

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0068Optical details of the image generation arrangements using polarisation
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036Scanning details, e.g. scanning stages
    • G02B21/0048Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0076Optical details of the image generation arrangements using fluorescence or luminescence
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/16Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/18Arrangements with more than one light path, e.g. for comparing two specimens
    • G02B21/20Binocular arrangements
    • G02B21/22Stereoscopic arrangements

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Stereoscopic And Panoramic Photography (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AT06710202T 2005-01-27 2006-01-27 Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung ATE418085T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0500143A HU227859B1 (en) 2005-01-27 2005-01-27 Real-time 3d nonlinear microscope measuring system and its application

Publications (1)

Publication Number Publication Date
ATE418085T1 true ATE418085T1 (de) 2009-01-15

Family

ID=89985773

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06710202T ATE418085T1 (de) 2005-01-27 2006-01-27 Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung

Country Status (6)

Country Link
US (1) US7872748B2 (de)
EP (1) EP1851580B1 (de)
AT (1) ATE418085T1 (de)
DE (1) DE602006004311D1 (de)
HU (1) HU227859B1 (de)
WO (1) WO2006079861A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7231243B2 (en) 2000-10-30 2007-06-12 The General Hospital Corporation Optical methods for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
JP4805142B2 (ja) 2003-03-31 2011-11-02 ザ ジェネラル ホスピタル コーポレイション 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少
US7519096B2 (en) 2003-06-06 2009-04-14 The General Hospital Corporation Process and apparatus for a wavelength tuning source
EP2293031B8 (de) 2003-10-27 2024-03-20 The General Hospital Corporation Verfahren und Vorrichtung für eine Lichtquelle mit Abstimmung der Wellenlänge
KR101239250B1 (ko) 2004-05-29 2013-03-05 더 제너럴 하스피탈 코포레이션 광간섭 단층촬영 화상 진단에서 반사층을 이용한 색 분산보상을 위한 프로세스, 시스템 및 소프트웨어 배열
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
JP5053845B2 (ja) 2004-08-06 2012-10-24 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス断層撮影法を使用して試料中の少なくとも1つの位置を決定するための方法、システムおよびソフトウェア装置
EP1793730B1 (de) 2004-08-24 2011-12-28 The General Hospital Corporation Verfahren, system und software-anordnung zur bestimmung des elastizitätsmoduls
WO2006024015A1 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Method and apparatus for imaging of vessel segments
WO2006039091A2 (en) 2004-09-10 2006-04-13 The General Hospital Corporation System and method for optical coherence imaging
EP2329759B1 (de) 2004-09-29 2014-03-12 The General Hospital Corporation System und Verfahren zur Abbildung optischer Kohärenz
JP2008521516A (ja) 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション サンプル上の複数の地点を同時に照射し検出することによって光学画像生成を実行する構成、装置、内視鏡、カテーテル、及び方法
ES2337497T3 (es) 2005-04-28 2010-04-26 The General Hospital Corporation Evaluacion de caracteristicas de la imagen de una estructura anatomica en imagenes de tomografia de coherencia optica.
JP5702049B2 (ja) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション 位相分解光学周波数領域画像化を行うための装置、方法及びシステム
ES2354287T3 (es) 2005-08-09 2011-03-11 The General Hospital Corporation Aparato y método para realizar una desmodulación en cuadratura por polarización en tomografía de coherencia óptica.
WO2007041382A1 (en) 2005-09-29 2007-04-12 General Hospital Corporation Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures
PL1973466T3 (pl) 2006-01-19 2021-07-05 The General Hospital Corporation Balonowy cewnik do obrazowania
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
EP2659852A3 (de) 2006-02-01 2014-01-15 The General Hospital Corporation Vorrichtung zur Anwendung mehrerer elektromagnetischer Strahlungen auf einer Probe
JP5524487B2 (ja) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
WO2007092911A2 (en) 2006-02-08 2007-08-16 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
JP2009527770A (ja) 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
EP2517616A3 (de) 2006-05-10 2013-03-06 The General Hospital Corporation Prozesse, Anordnungen und Systeme zur Bereitstellung der Frequenzbereichsabbildung einer Probe
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
EP2132840A2 (de) 2007-03-23 2009-12-16 The General Hospital Corporation Verfahren, anordnungen und vorrichtung zur verwendung eines wellenlängengewobbelten lasers anhand von winkelabtastungs und dispersionsverfahren
WO2008121844A1 (en) 2007-03-30 2008-10-09 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
WO2008131082A1 (en) 2007-04-17 2008-10-30 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques
US7566173B2 (en) * 2007-07-09 2009-07-28 Alcon, Inc. Multi-spot ophthalmic laser probe
JP5038094B2 (ja) * 2007-10-31 2012-10-03 オリンパス株式会社 レーザー走査型顕微鏡
US8059274B2 (en) * 2007-12-07 2011-11-15 The Spectranetics Corporation Low-loss polarized light diversion
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
JP5607610B2 (ja) 2008-05-07 2014-10-15 ザ ジェネラル ホスピタル コーポレイション 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体
WO2009155536A2 (en) 2008-06-20 2009-12-23 The General Hospital Corporation Fused fiber optic coupler arrangement and method for use thereof
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
US8937724B2 (en) 2008-12-10 2015-01-20 The General Hospital Corporation Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
EP2389093A4 (de) 2009-01-20 2013-07-31 Gen Hospital Corp Endoskopische biopsievorrichtung sowie entsprechendes system und verfahren
WO2010085775A2 (en) * 2009-01-26 2010-07-29 The General Hospital Corporation System, method and computer-accessible medium for providing wide-field superresolution microscopy
JP6053284B2 (ja) 2009-02-04 2016-12-27 ザ ジェネラル ホスピタル コーポレイション ハイスピード光学波長チューニング源の利用のための装置及び方法
WO2011008822A2 (en) 2009-07-14 2011-01-20 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
JP5902623B2 (ja) * 2009-11-24 2016-04-13 アルコン リサーチ, リミテッド 眼内照明のためのシングルファイバーマルチスポットレーザプローブ
US9304308B2 (en) * 2009-12-09 2016-04-05 Advanced Micro Devices, Inc. Laser scanning module including an optical isolator
US8951244B2 (en) * 2009-12-15 2015-02-10 Alcon Research, Ltd. Multi-spot laser probe
WO2011109828A2 (en) 2010-03-05 2011-09-09 The General Hospital Corporation Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP2575598A2 (de) 2010-05-25 2013-04-10 The General Hospital Corporation Vorrichtungen, systeme, verfahren und computerlesbares medium zur spektralanalyse von bildern aus einer optischen kohärenz-tomographie
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
JP2012042669A (ja) * 2010-08-18 2012-03-01 Sony Corp 顕微鏡制御装置及び光学的歪み補正方法
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8982206B2 (en) * 2011-04-07 2015-03-17 Uwm Research Foundation, Inc. High speed microscope with narrow detector and pixel binning
WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
EP2769491A4 (de) 2011-10-18 2015-07-22 Gen Hospital Corp Vorrichtung und verfahren zur herstellung und/oder bereitstellung rezirkulierender optischer verzögerung(en)
EP2833776A4 (de) 2012-03-30 2015-12-09 Gen Hospital Corp Abbildungssystem, verfahren und distaler anschluss zur multidirektionalen sichtfeldendoskopie
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
EP2888616A4 (de) 2012-08-22 2016-04-27 Gen Hospital Corp System, verfahren, und über computer zugängliches medium zur herstellung eines miniaturendoskops mit weicher lithografie
US10245181B2 (en) 2012-12-21 2019-04-02 Alcon Research, Ltd. Grin fiber multi-spot laser probe
EP2948758B1 (de) 2013-01-28 2024-03-13 The General Hospital Corporation Vorrichtung zur bereitstellung von gemeinsam mit optischer frequenzdomänenbildgebung aufgezeichneter diffuser spektroskopie
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
JP6378311B2 (ja) 2013-03-15 2018-08-22 ザ ジェネラル ホスピタル コーポレイション 物体を特徴付ける方法とシステム
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
US10117576B2 (en) 2013-07-19 2018-11-06 The General Hospital Corporation System, method and computer accessible medium for determining eye motion by imaging retina and providing feedback for acquisition of signals from the retina
EP3025173B1 (de) 2013-07-26 2021-07-07 The General Hospital Corporation Vorrichtung mit optische dispersion nutzender laseranordnung zur anwendung in der fourier-raum optischen kohärenztomographie
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
EP3171766B1 (de) 2014-07-25 2021-12-29 The General Hospital Corporation Einrichtung zur in-vivo-bildgebung und -diagnose
WO2016178856A1 (en) 2015-05-01 2016-11-10 The Board Of Regents Of The University Of Texas System Uniform and scalable light-sheets generated by extended focusing
US9696255B2 (en) * 2015-10-16 2017-07-04 National Central University Image processing method of two-photon structured illumination point scanning microscopy
WO2017180680A1 (en) 2016-04-12 2017-10-19 The Board Of Regents Of The University Of Texas System LIGHT-SHEET MICROSCOPE WITH PARALLELIZED 3D lMAGE ACQUISITION
TWI582407B (zh) * 2016-05-06 2017-05-11 國立中央大學 粒子三維定位與追蹤裝置及其方法
DE102017120317A1 (de) * 2017-09-04 2019-03-07 Leica Microsystems Cms Gmbh Optische Anordnung und Verfahren zur Beeinflussung einer Dispersion von Wellenlängen mindestens eines Lichtpulses oder Lichtstrahls
US20190101489A1 (en) * 2017-09-29 2019-04-04 Michael John Darwin Method and Apparatus for Simultaneously Measuring 3Dimensional Structures and Spectral Content of Said Structures
DE102017127424B3 (de) * 2017-11-21 2019-04-25 Bruker Optik Gmbh Mikroskop
CN116592775B (zh) * 2023-05-30 2023-12-22 北京国光领航科技有限公司 一种基于色散测量拉锥光纤芯径的测量装置及其测量方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
WO1994010595A1 (en) 1992-10-23 1994-05-11 Monash University Confocal microscope and endoscope
US6411835B1 (en) * 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5995281A (en) * 1997-04-09 1999-11-30 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in an optical beam path of a microscope
AU779659B2 (en) 2000-02-08 2005-02-03 Cornell Research Foundation Inc. Multiphoton excitation through optical fibers for fluorescence spectroscopy
DE10044308A1 (de) * 2000-09-07 2002-03-21 Leica Microsystems Verfahren und Vorrichtung zur Detektion von Fluoreszenzlicht bei der konfokalen Rastermikroskopie

Also Published As

Publication number Publication date
DE602006004311D1 (de) 2009-01-29
EP1851580A1 (de) 2007-11-07
EP1851580B1 (de) 2008-12-17
HUP0500143A2 (en) 2006-07-28
US7872748B2 (en) 2011-01-18
HU0500143D0 (en) 2005-03-29
HU227859B1 (en) 2012-05-02
US20080308730A1 (en) 2008-12-18
WO2006079861A1 (en) 2006-08-03

Similar Documents

Publication Publication Date Title
ATE418085T1 (de) Nichtlineares echtzeit-3d-mikroskopmessystem und verfahren zu seiner anwendung
EP1664854B1 (de) Faseroptisches ablieferungs- und sammelsystem für biologische anwendungen
Bader et al. Impact of pulse duration on Ho: YAG laser lithotripsy: fragmentation and dusting performance
Bauer-Marschallinger et al. All-optical photoacoustic projection imaging
CN104330398B (zh) 一种多模式非线性光学显微成像方法及装置
US20120307238A1 (en) Microscope and observation method
US20140347462A1 (en) Quantitative nonlinear optical microscopy using a shaped beam
EP1186930A3 (de) Vorrichtung und Verfahren zur Untersuchung und Manipulation von mikroskopischen Objekten
JP2007503851A5 (de)
ATE468069T1 (de) Verfahren und vorrichtung zur hochauflösenden fluoreszierenden abbildung mit optischen fasern und insbesondere konfokale abbildung
CN101477047B (zh) 基于透镜几何光学成像的非线性吸收测量方法
DE112015006288B4 (de) Optische Messvorrichtung und optisches Messverfahren
Turcotte et al. Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy
Krug et al. Nonlinear microscopy using impulsive stimulated Brillouin scattering for high-speed elastography
Dal Fovo et al. Nonlinear optical microscopy for artworks physics
DE60227774D1 (de) Verfahren und Vorrichtung zur Messung des nichtlinearen Brechungskoeffizienten eines Lichtwellenleiters
Brakenhoff et al. Femtosecond pulse width control in microscopy by two‐photon absorption autocorrelation
Koukoulas et al. Towards a future primary method for microphone calibration: Optical measurement of acoustic velocity in low seeding conditions
He et al. 3‐photon fluorescence imaging of sulforhodamine B‐labeled elastic fibers in the mouse skin in vivo
Chen et al. Recent advances in optical microscopy methods for subcellular imaging of thick biological tissues
Karpf et al. High speed two-photon lifetime imaging
CN204694613U (zh) 一种显微光谱分析成像系统
Tiwari Non-Linear Endoscopic Microscopy System for Potential use in Diagnosing Rheumatoid Arthritis
Dumas et al. Innovative TCSPC–SHG microscopy imaging to monitor matrix collagen neo-synthetized in bioscaffolds
JP3787634B2 (ja) 生体内物質の濃度計測方法及び濃度計測装置

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties