ATE413173T1 - Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung - Google Patents
Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmungInfo
- Publication number
- ATE413173T1 ATE413173T1 AT05816322T AT05816322T ATE413173T1 AT E413173 T1 ATE413173 T1 AT E413173T1 AT 05816322 T AT05816322 T AT 05816322T AT 05816322 T AT05816322 T AT 05816322T AT E413173 T1 ATE413173 T1 AT E413173T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibition
- serotonin
- reuppost
- combination
- phenylpiperazine derivatives
- Prior art date
Links
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 230000008484 agonism Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- 229940076279 serotonin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000697 serotonin reuptake Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63407404P | 2004-12-08 | 2004-12-08 | |
| EP04106394 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE413173T1 true ATE413173T1 (de) | 2008-11-15 |
Family
ID=35744728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05816322T ATE413173T1 (de) | 2004-12-08 | 2005-12-06 | Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung |
| AT05850037T ATE401883T1 (de) | 2004-12-08 | 2005-12-06 | Aryloxyethylaminderivate mit einer kombination aus partiellem dopamin-d2-rezeptoragonismus und serotonin-wiederaufnahmehemmung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05850037T ATE401883T1 (de) | 2004-12-08 | 2005-12-06 | Aryloxyethylaminderivate mit einer kombination aus partiellem dopamin-d2-rezeptoragonismus und serotonin-wiederaufnahmehemmung |
Country Status (18)
| Country | Link |
|---|---|
| EP (4) | EP1824479B1 (https=) |
| JP (4) | JP2008523031A (https=) |
| KR (4) | KR20070085988A (https=) |
| AT (2) | ATE413173T1 (https=) |
| AU (4) | AU2005313311A1 (https=) |
| BR (1) | BRPI0518613A2 (https=) |
| CA (4) | CA2587559A1 (https=) |
| DE (2) | DE602005008471D1 (https=) |
| DK (2) | DK1827427T3 (https=) |
| ES (2) | ES2311245T3 (https=) |
| HR (2) | HRP20080538T3 (https=) |
| IL (4) | IL183061A0 (https=) |
| NO (4) | NO20072974L (https=) |
| PL (2) | PL1824479T3 (https=) |
| PT (2) | PT1824479E (https=) |
| RU (4) | RU2007125659A (https=) |
| SI (2) | SI1824479T1 (https=) |
| WO (4) | WO2006061376A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009525304A (ja) * | 2006-01-30 | 2009-07-09 | シュペーデル・エクスペリメンタ・アーゲー | α，β−不飽和化合物からのアルコールの立体選択的製造方法 |
| US8063062B2 (en) | 2006-12-20 | 2011-11-22 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition |
| EP2111394A1 (en) * | 2007-01-10 | 2009-10-28 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition |
| US8138174B2 (en) | 2007-01-10 | 2012-03-20 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition |
| RS52518B (sr) * | 2007-04-23 | 2013-04-30 | Janssen Pharmaceutica N.V. | Derivati 4-alkoksipiridazina kao brzo disocirajući dopamin 2 receptorski antagonisti |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| US20100137368A1 (en) * | 2007-04-23 | 2010-06-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| CN103360342B (zh) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用 |
| CN103570698B (zh) * | 2012-08-01 | 2016-08-03 | 江苏恩华药业股份有限公司 | 用于制备维拉佐酮的化合物及其中间体和应用 |
| ITMI20130392A1 (it) * | 2013-03-15 | 2014-09-16 | Dipharma Francis Srl | Sintesi di un inibitore della ricaptazione della serotonina |
| WO2014203217A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| WO2014207648A1 (en) | 2013-06-24 | 2014-12-31 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| JP2002510675A (ja) * | 1998-04-08 | 2002-04-09 | アメリカン・ホーム・プロダクツ・コーポレイション | うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン（５−ｈｔ１ａ受容体活性薬） |
| HUP0101475A3 (en) * | 1998-06-19 | 2003-01-28 | Lundbeck & Co As H | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| WO2001014330A2 (en) * | 1999-08-23 | 2001-03-01 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| BR0317126A (pt) * | 2002-12-10 | 2005-10-25 | Merck Patent Gmbh | Derivados de indol e o uso dos mesmos como ligantes de 5-ht |
-
2005
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Withdrawn
- 2005-12-06 DK DK05850037T patent/DK1827427T3/da active
- 2005-12-06 EP EP05816322A patent/EP1824479B1/en not_active Expired - Lifetime
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Withdrawn
- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 SI SI200530566T patent/SI1824479T1/sl unknown
- 2005-12-06 CA CA002587559A patent/CA2587559A1/en not_active Abandoned
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 CA CA002587381A patent/CA2587381A1/en not_active Abandoned
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Withdrawn
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/en not_active Ceased
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
- 2005-12-06 EP EP05816324A patent/EP1824480A1/en not_active Withdrawn
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/en not_active Ceased
- 2005-12-06 PT PT05816322T patent/PT1824479E/pt unknown
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/en not_active Ceased
- 2005-12-06 AU AU2005313312A patent/AU2005313312A1/en not_active Abandoned
- 2005-12-06 PT PT05850037T patent/PT1827427E/pt unknown
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 EP EP05813645A patent/EP1827426A1/en not_active Withdrawn
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Withdrawn
- 2005-12-06 HR HR20080538T patent/HRP20080538T3/xx unknown
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 CA CA002587202A patent/CA2587202A1/en not_active Abandoned
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 AT AT05850037T patent/ATE401883T1/de not_active IP Right Cessation
- 2005-12-06 HR HR20090015T patent/HRP20090015T3/xx unknown
- 2005-12-06 BR BRPI0518613-7A patent/BRPI0518613A2/pt not_active IP Right Cessation
- 2005-12-06 EP EP05850037A patent/EP1827427B1/en not_active Expired - Lifetime
- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 ES ES05850037T patent/ES2311245T3/es not_active Expired - Lifetime
- 2005-12-06 PL PL05850037T patent/PL1827427T3/pl unknown
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es not_active Expired - Lifetime
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/en not_active Ceased
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
- 2005-12-06 CA CA002587357A patent/CA2587357A1/en not_active Abandoned
- 2005-12-06 RU RU2007125661/04A patent/RU2007125661A/ru not_active Application Discontinuation
-
2007
- 2007-05-08 IL IL183061A patent/IL183061A0/en unknown
- 2007-05-08 IL IL183064A patent/IL183064A0/en unknown
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
- 2007-05-08 IL IL183063A patent/IL183063A0/en unknown
- 2007-06-11 NO NO20072974A patent/NO20072974L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072981A patent/NO20072981L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1824479 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |