ATE411525T1 - Nachweis einer histonmodifikation in zellfreien nukleosomen - Google Patents
Nachweis einer histonmodifikation in zellfreien nukleosomenInfo
- Publication number
- ATE411525T1 ATE411525T1 AT04768123T AT04768123T ATE411525T1 AT E411525 T1 ATE411525 T1 AT E411525T1 AT 04768123 T AT04768123 T AT 04768123T AT 04768123 T AT04768123 T AT 04768123T AT E411525 T1 ATE411525 T1 AT E411525T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- free nucleosomes
- detection
- nucleosomes
- histone modification
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Geophysics And Detection Of Objects (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0319376.0A GB0319376D0 (en) | 2003-08-18 | 2003-08-18 | Histone modification detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411525T1 true ATE411525T1 (de) | 2008-10-15 |
Family
ID=28052702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04768123T ATE411525T1 (de) | 2003-08-18 | 2004-08-18 | Nachweis einer histonmodifikation in zellfreien nukleosomen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9128086B2 (de) |
| EP (1) | EP1668368B1 (de) |
| AT (1) | ATE411525T1 (de) |
| DE (1) | DE602004017201D1 (de) |
| DK (1) | DK1668368T3 (de) |
| ES (1) | ES2315697T3 (de) |
| GB (1) | GB0319376D0 (de) |
| SI (1) | SI1668368T1 (de) |
| WO (1) | WO2005019826A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| CA2607327A1 (en) * | 2005-04-29 | 2006-11-09 | The Regents Of The University Of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
| US8119572B2 (en) * | 2005-10-24 | 2012-02-21 | Wisconsin Alumni Research Foundation | Methods for determining protein binding specificity using peptide libraries |
| WO2012040523A2 (en) | 2010-09-24 | 2012-03-29 | The Rockefeller University | Phosphohistidine analogs |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115099D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes |
| PL2788767T3 (pl) | 2011-12-07 | 2018-03-30 | Belgian Volition Sprl | Sposób wykrywania adduktów nukleosomowych |
| GB201303576D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for predicting therapy efficacy using nucleosome structure biomarkers |
| GB201303575D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for detecting histone modifications in nucleosomes |
| EP2775304A1 (de) * | 2013-03-07 | 2014-09-10 | Universitätsspital Basel | Verfahren zum Nachweis einer entzündlichen Störung |
| AU2015340378B2 (en) | 2014-10-29 | 2021-08-12 | Belgian Volition Sprl | Method for the enrichment of circulating tumor DNA |
| GB201518665D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for enrichment of cell free nucleosomes |
| GB201518674D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for detecting nuleosomes containing histone modifications and variants |
| JP6994469B2 (ja) | 2016-04-20 | 2022-02-04 | エアラン セル テクノロジーズ， インコーポレイテッド | Ｋ１８０ジメチル化ｈ１．０タンパク質に関連する組成物および方法 |
| TWI726009B (zh) * | 2016-11-28 | 2021-05-01 | 比利時商比利時意志有限公司 | 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途 |
| CA3084620C (en) | 2017-09-18 | 2024-06-18 | Santersus Sa | Method and device for purification of blood from circulating cell free dna |
| EP3700569A4 (de) | 2017-10-25 | 2021-08-25 | Aelan Cell Technologies, Inc. | H1.0k180me2-antikörper, verfahren zur herstellung und verwendungen davon |
| GB201721569D0 (en) | 2017-12-21 | 2018-02-07 | Belgian Volition Sprl | Method for the detection and treatment of colorectal adenomas |
| US20200332370A1 (en) * | 2018-01-10 | 2020-10-22 | EpiCypher, Inc | Methods for Quantification of Nucleosome Modifications and Mutations at Genomic Loci and Clinical Applications Thereof |
| AU2019228625A1 (en) | 2018-03-01 | 2020-09-03 | Epicypher, Inc. | Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes |
| EP3765638A2 (de) | 2018-03-13 | 2021-01-20 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Diagnostische verwendung von zellfreier dna-chromatin-immunpräzipitation |
| EP3856903A4 (de) | 2018-09-27 | 2022-07-27 | Grail, LLC | Methylierungsmarker und gezieltes methylierungssondenpaneel |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| KR20220111246A (ko) | 2019-08-27 | 2022-08-09 | 벨지언 볼리션 에스알엘 | 순환 뉴클레오솜을 단리하는 방법 |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| KR20220110794A (ko) | 2019-12-02 | 2022-08-09 | 벨지언 볼리션 에스알엘 | 바이오마커로서의 무세포 뉴클레오솜의 사용 |
| JP2023520168A (ja) | 2020-03-20 | 2023-05-16 | ベルジアン ボリション エスアールエル | 無細胞ヌクレオソームレベルを用いるトリアージ方法 |
| US20230355851A1 (en) | 2020-09-21 | 2023-11-09 | Belgian Volition SRL (BE/BE) | Device for inline monitoring of free nucleosomes in blood |
| CA3195344A1 (en) * | 2020-11-02 | 2022-05-05 | Matthew R. MARUNDE | Improved assays to quantify chromatin targets using antibody-targeted enzyme digestion |
| TW202238131A (zh) | 2020-11-25 | 2022-10-01 | 比利時商比利時意志有限公司 | 測量無細胞核蛋白染色質片段之方法 |
| TW202238132A (zh) | 2020-12-08 | 2022-10-01 | 比利時商比利時意志有限公司 | 多發性硬化症之診斷方法 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242146A (zh) | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| GB202108452D0 (en) | 2021-06-14 | 2021-07-28 | Belgian Volition Sprl | Triaging method using cell free nucleosome levels |
| WO2023073179A1 (en) | 2021-10-29 | 2023-05-04 | Belgian Volition Srl | Homogeneous immunoassay method |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| WO2023170298A1 (en) | 2022-03-11 | 2023-09-14 | Belgian Volition Srl | Differential diagnosis method |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| WO2024042208A1 (en) | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for the detection of dementia |
| WO2024042210A1 (en) | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3517642B2 (ja) * | 1998-03-18 | 2004-04-12 | ロシュ ダイアグノスティックス ゲーエムベーハー | アポトーシス産物の検出 |
| US20040197838A1 (en) | 2001-08-03 | 2004-10-07 | Allis C David | Phosphorylated histone h2b as apoptosis marker |
| RU2004116344A (ru) * | 2001-11-30 | 2005-03-27 | Пфайзер Продактс Инк. (Us) | Способы детекции клеток с аномалиями в числе хромосом |
| AU2003216291A1 (en) | 2002-02-20 | 2003-09-09 | Chroma Therapeutics Ltd. | A non-invasive diagnostic test utilizing histone modification markers |
| WO2004080288A2 (en) * | 2003-03-10 | 2004-09-23 | University Of Virginia Patent Foundation | Post-translational modifications of proteins as regulatory switches |
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| CA2607327A1 (en) * | 2005-04-29 | 2006-11-09 | The Regents Of The University Of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
-
2003
- 2003-08-18 GB GBGB0319376.0A patent/GB0319376D0/en not_active Ceased
-
2004
- 2004-08-18 US US10/568,691 patent/US9128086B2/en active Active
- 2004-08-18 WO PCT/GB2004/003564 patent/WO2005019826A1/en active Application Filing
- 2004-08-18 DE DE602004017201T patent/DE602004017201D1/de active Active
- 2004-08-18 EP EP04768123A patent/EP1668368B1/de active Active
- 2004-08-18 DK DK04768123T patent/DK1668368T3/da active
- 2004-08-18 ES ES04768123T patent/ES2315697T3/es active Active
- 2004-08-18 SI SI200430992T patent/SI1668368T1/sl unknown
- 2004-08-18 AT AT04768123T patent/ATE411525T1/de active
-
2015
- 2015-08-03 US US14/816,329 patent/US10408831B2/en active Active
-
2019
- 2019-07-26 US US16/523,096 patent/US20190353653A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070160989A1 (en) | 2007-07-12 |
| ES2315697T3 (es) | 2009-04-01 |
| DK1668368T3 (da) | 2009-02-23 |
| US20190353653A1 (en) | 2019-11-21 |
| US10408831B2 (en) | 2019-09-10 |
| SI1668368T1 (sl) | 2009-04-30 |
| WO2005019826A1 (en) | 2005-03-03 |
| US9128086B2 (en) | 2015-09-08 |
| DE602004017201D1 (de) | 2008-11-27 |
| EP1668368A1 (de) | 2006-06-14 |
| US20150330996A1 (en) | 2015-11-19 |
| EP1668368B1 (de) | 2008-10-15 |
| GB0319376D0 (en) | 2003-09-17 |
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| UEP | Publication of translation of european patent specification |
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