ATE411317T1 - Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen - Google Patents

Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Info

Publication number
ATE411317T1
ATE411317T1 AT03793096T AT03793096T ATE411317T1 AT E411317 T1 ATE411317 T1 AT E411317T1 AT 03793096 T AT03793096 T AT 03793096T AT 03793096 T AT03793096 T AT 03793096T AT E411317 T1 ATE411317 T1 AT E411317T1
Authority
AT
Austria
Prior art keywords
compounds
carbinol
chemotherapeutic
metabolites
indole
Prior art date
Application number
AT03793096T
Other languages
German (de)
English (en)
Inventor
Ling Jong
Wan-Ru Chao
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Application granted granted Critical
Publication of ATE411317T1 publication Critical patent/ATE411317T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AT03793096T 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen ATE411317T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/224,979 US6800655B2 (en) 2002-08-20 2002-08-20 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Publications (1)

Publication Number Publication Date
ATE411317T1 true ATE411317T1 (de) 2008-10-15

Family

ID=31946289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03793096T ATE411317T1 (de) 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Country Status (8)

Country Link
US (4) US6800655B2 (OSRAM)
EP (2) EP1623985B1 (OSRAM)
JP (3) JP4764629B2 (OSRAM)
AT (1) ATE411317T1 (OSRAM)
AU (1) AU2003263878A1 (OSRAM)
CA (1) CA2496203C (OSRAM)
DE (1) DE60324155D1 (OSRAM)
WO (1) WO2004018475A2 (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
WO2005107747A2 (en) * 2004-05-06 2005-11-17 Bioresponse, Llc Diindolymethane formulations for the treatment of leiomyomas
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
CA2593084C (en) 2004-12-30 2014-03-18 Bioresponse, Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
CA2609980C (en) * 2005-05-27 2015-10-13 Queen's University At Kingston Treatment of protein folding disorders
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
KR101507173B1 (ko) 2006-04-18 2015-03-30 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 활성화 수용체 δ 의 활성화제
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US7807705B2 (en) * 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US20100292316A1 (en) * 2007-07-18 2010-11-18 Research Development Foundation Improved therapeutic methods and compositions comprising chroman ring compounds
US8648208B2 (en) * 2008-04-15 2014-02-11 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor
US8278341B2 (en) * 2008-09-17 2012-10-02 Sri International Analogs of indole-3-carbinol and their use as agents against infection
KR101477613B1 (ko) * 2009-03-31 2014-12-30 롬엔드하스전자재료코리아유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전자 소자
US20120184590A1 (en) * 2009-04-09 2012-07-19 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
EP2464349A2 (en) * 2009-08-14 2012-06-20 Cerenis Therapeutics S.A. Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
DE102009052428A1 (de) * 2009-11-10 2011-05-12 Merck Patent Gmbh Verbindung für elektronische Vorrichtungen
CN102917707A (zh) * 2010-05-06 2013-02-06 默沙东公司 可用作faah调节剂的氮杂吲哚衍生物
CN103764143B (zh) * 2011-04-01 2017-05-03 斯坦福国际咨询研究所 脂氧合酶抑制剂
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
WO2017011920A1 (en) * 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
CN105218552B (zh) * 2015-09-30 2018-02-27 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用
CN110698654B (zh) * 2018-07-10 2021-04-02 中国科学院长春应用化学研究所 基于三聚吲哚的超支化共轭聚电解质及其制备方法和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1282451B (de) 1965-09-01 1968-11-07 Kalle Ag Lichtempfindliche Schicht und Verfahren zur Herstellung fixierter Bilder
US4636820A (en) 1980-03-06 1987-01-13 The Hilton-Davis Chemical Compositions, process and systems
EP0266310B1 (de) * 1986-10-28 2001-12-05 Ciba SC Holding AG Chromogene Phthalide
GB8713564D0 (en) 1987-06-10 1987-07-15 Kong Y C Synthesis
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
US5086171A (en) 1989-03-08 1992-02-04 Appleton Papers Inc. Bis-(indolyl)ethylenes
US5116978A (en) 1989-03-08 1992-05-26 Appleton Papers Inc. Process for bis(indolyl)ethylene synthesis
JP3038064B2 (ja) 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
EP0540468B1 (de) 1991-10-30 1996-12-04 Ciba-Geigy Ag NIR-Farbstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5407102A (en) * 1994-02-15 1995-04-18 Freudinger; Mark J. Apparatus for dispensing a quantity of flowable material
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
US5843607A (en) * 1997-10-02 1998-12-01 Xerox Corporation Indolocarbazole photoconductors
US5942340A (en) 1997-10-02 1999-08-24 Xerox Corporation Indolocarbazole electroluminescent devices
IL139056A0 (en) * 1998-05-04 2001-11-25 Asta Medica Ag Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation
WO2000002857A1 (en) 1998-07-08 2000-01-20 Harbor Branch Oceanographic Institution, Inc. Bis-indole derivatives and their use as antiinflammatory agents
IT1317926B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
IT1317925B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
JP2003346530A (ja) * 2002-05-23 2003-12-05 Nippon Sheet Glass Co Ltd 面状光源装置および画像読み取り装置
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Also Published As

Publication number Publication date
EP1623985B1 (en) 2016-02-17
US7078427B2 (en) 2006-07-18
US20090023796A1 (en) 2009-01-22
US20040043965A1 (en) 2004-03-04
US7429610B2 (en) 2008-09-30
US20040157906A1 (en) 2004-08-12
WO2004018475A3 (en) 2004-04-01
WO2004018475A2 (en) 2004-03-04
EP1623985A3 (en) 2011-06-08
EP1623985A2 (en) 2006-02-08
EP1530572B1 (en) 2008-10-15
JP5599236B2 (ja) 2014-10-01
JP2006036796A (ja) 2006-02-09
JP2006500379A (ja) 2006-01-05
JP4764629B2 (ja) 2011-09-07
CA2496203A1 (en) 2004-03-04
AU2003263878A1 (en) 2004-03-11
EP1530572A2 (en) 2005-05-18
US20060128785A1 (en) 2006-06-15
DE60324155D1 (de) 2008-11-27
US7666897B2 (en) 2010-02-23
JP4699171B2 (ja) 2011-06-08
US6800655B2 (en) 2004-10-05
JP2010195840A (ja) 2010-09-09
CA2496203C (en) 2012-03-27

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