ATE408618T1 - Synthetische peptidkonstrukte zur erkennung und behandlung von parodontose hervorgerufen durch porphyromonas gingivalis - Google Patents

Synthetische peptidkonstrukte zur erkennung und behandlung von parodontose hervorgerufen durch porphyromonas gingivalis

Info

Publication number
ATE408618T1
ATE408618T1 AT98916667T AT98916667T ATE408618T1 AT E408618 T1 ATE408618 T1 AT E408618T1 AT 98916667 T AT98916667 T AT 98916667T AT 98916667 T AT98916667 T AT 98916667T AT E408618 T1 ATE408618 T1 AT E408618T1
Authority
AT
Austria
Prior art keywords
periodontosis
caused
detection
treatment
porphyromonas gingivalis
Prior art date
Application number
AT98916667T
Other languages
English (en)
Inventor
Eric Reynolds
Neil O'brien-Simpson
Nada Slakeski
Original Assignee
Univ Melbourne
Csl Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Melbourne, Csl Ltd filed Critical Univ Melbourne
Application granted granted Critical
Publication of ATE408618T1 publication Critical patent/ATE408618T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98916667T 1997-04-30 1998-04-30 Synthetische peptidkonstrukte zur erkennung und behandlung von parodontose hervorgerufen durch porphyromonas gingivalis ATE408618T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO6528A AUPO652897A0 (en) 1997-04-30 1997-04-30 Synthetic peptide constructs for the diagnosis and treatment of periodontitis

Publications (1)

Publication Number Publication Date
ATE408618T1 true ATE408618T1 (de) 2008-10-15

Family

ID=3800820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98916667T ATE408618T1 (de) 1997-04-30 1998-04-30 Synthetische peptidkonstrukte zur erkennung und behandlung von parodontose hervorgerufen durch porphyromonas gingivalis

Country Status (12)

Country Link
US (4) US7262271B2 (de)
EP (3) EP2246361A1 (de)
JP (1) JP4276300B2 (de)
KR (1) KR100356040B1 (de)
AT (1) ATE408618T1 (de)
AU (1) AUPO652897A0 (de)
CA (4) CA2720332C (de)
DE (1) DE69840027D1 (de)
DK (1) DK1017714T3 (de)
ES (1) ES2530510T3 (de)
NZ (1) NZ500451A (de)
WO (1) WO1998049192A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN627595A0 (en) * 1995-10-30 1995-11-23 University Of Melbourne, The Diagnostics and treatments of periodontal disease
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
JP2001526035A (ja) * 1997-12-10 2001-12-18 シーエスエル、リミテッド Ｐｏｒｐｈｏｒｙｍｏｎａｓｇｉｎｇｉｖａｌｉｓポリペプチドおよびヌクレオチド
US8129500B2 (en) * 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
AUPP893999A0 (en) * 1999-03-01 1999-03-25 Csl Limited Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis
AUPQ485999A0 (en) * 1999-12-24 2000-02-03 Csl Limited P. gingivalis antigenic composition
WO2004067020A1 (en) * 2003-01-30 2004-08-12 Pohang University Of Science And Technology Dna vaccine composition with enhanced immunogenicity
NZ554331A (en) 2004-09-23 2009-04-30 Univ Melbourne Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection
US20100092471A1 (en) 2006-06-27 2010-04-15 Oral Health Australia Pty Ltd Porphyromonas Gingivalis Polypeptides Useful in the Prevention of Periodontal Disease
AU2008274906B2 (en) * 2007-07-12 2013-11-07 Oral Health Australia Pty Ltd Biofilm treatment
CA2693717A1 (en) 2007-07-12 2009-01-15 Stuart Geoffrey Dashper Immunology treatment for biofilms
US8142764B2 (en) 2008-02-27 2012-03-27 University Of Louisville Research Foundation Synthetic biofilm-inhibiting peptides
KR101721904B1 (ko) * 2008-08-29 2017-04-11 오럴 헬스 오스트레일리아 피티와이 엘티디 Ｐ．진지발리스 감염의 예방, 치료 및 진단
US8140041B2 (en) * 2009-08-27 2012-03-20 Mediatek Inc. Tunable capacitive device with linearization technique employed therein
MY162557A (en) * 2010-02-26 2017-06-15 Oral Health Australia Pty Ltd Treatment or prevention of infection
WO2018063801A1 (en) * 2016-09-29 2018-04-05 Meharry Medical College Bacterial inhibitors
CN113419059B (zh) * 2021-06-30 2023-09-01 迈克生物股份有限公司 用于化学发光免疫分析方法的封闭剂

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837151A (en) 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US5210035A (en) 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4735801A (en) 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
JPS60142915A (ja) * 1983-12-28 1985-07-29 Lion Corp 口腔用組成物
US4693888A (en) * 1983-08-11 1987-09-15 Lion Corporation Caries-preventive composition
AU557164B2 (en) * 1984-03-30 1986-12-11 Otsuka Kagaku Kabushiki Kaisha Preparation of fibrous alkali metal titanate
JPH0699291B2 (ja) * 1985-06-14 1994-12-07 ライオン株式会社 口腔用組成物
US5013542A (en) * 1988-02-08 1991-05-07 Forsyth Dental Infirmary For Children Method to inhibit adhesion of disease-causing microorganisms to teeth
IT8820888A0 (it) * 1988-06-08 1988-06-08 Eniricerche Spa Peptidi di sintesi immunologicamente attivi per lapreparazione di vaccini antimalarici.
US5824791A (en) * 1988-09-08 1998-10-20 University Of Florida Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease
US5830710A (en) * 1988-09-08 1998-11-03 University Of Florida Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease
US5665559A (en) * 1989-05-18 1997-09-09 The United States Of America As Represented By The Secretary Of The Navy Production of monoclonal antibodies to bacteroides gingivalis by hybridoma BGII, VF9/2D
DE4324859A1 (de) * 1992-07-23 1994-01-27 Lion Corp Oral verabreichbare Zusammensetzung zur Behandlung periodontaler Erkrankungen
US5536497A (en) * 1992-12-21 1996-07-16 The Research Foundation Of State University Of New York Fimbrial polypeptides useful in the prevention of periodontitis
CA2153661A1 (en) * 1993-01-12 1994-07-21 Anthony George Gristina Methods and compositions for the direct concentrated delivery of passive immunity
AU6983594A (en) * 1993-06-28 1995-01-17 Lion Corporation Composition for oral cavity
US5523390A (en) * 1993-09-10 1996-06-04 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase
US5475097A (en) 1993-10-21 1995-12-12 University Of Georgia Research Foundation, Inc. Lysine-specific Porphyromonas gingivalis proteinase
WO1995007286A1 (en) * 1993-09-10 1995-03-16 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase coding sequences
US6017532A (en) * 1993-09-10 2000-01-25 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase
JPH0797395A (ja) 1993-09-28 1995-04-11 Kyowa Medex Co Ltd ポルフイロモナス・ジンジバリス線毛蛋白質の配列を含有するペプチド類及びその用途
US5840302A (en) * 1993-11-10 1998-11-24 Bristol-Myers Squibb Company Treatment of bacterially-induced inflammatory diseases
WO1995026404A1 (fr) 1994-03-29 1995-10-05 Kyowa Hakko Kogyo Co., Ltd. Gene de polypeptide de surface
FI98961C (fi) * 1994-08-26 1997-09-10 Medix Biochemica Ab Oy Menetelmät ja määritysvälineet parodontaalisairauden aktiivisuuden ja/tai peri-implantiitin ja/tai niiden kohonneen riskin diagnosoimiseksi
US20030157637A1 (en) * 1998-09-15 2003-08-21 The University Of Melbourne Diagnostics and treatments of periodontal disease
AUPN627595A0 (en) 1995-10-30 1995-11-23 University Of Melbourne, The Diagnostics and treatments of periodontal disease
JP2000507245A (ja) * 1996-03-22 2000-06-13 ユニバーシティー オブ ジョージア リサーチ ファウンデーション，インコーポレイテッド Ｐｏｒｐｈｙｒｏｍｏｎａｓ ｇｉｎｇｉｖａｌｉｓペプチドを含む免疫原性組成物および方法
AUPN901296A0 (en) * 1996-03-29 1996-04-26 University Of Melbourne, The Porphyromonas gingivalis antigens for the diagnosis and treatment of periodontitis
US7341727B1 (en) 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
AUPO652897A0 (en) * 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
AUPP083997A0 (en) 1997-12-10 1998-01-08 Csl Limited Porphyromonas gingivalis nucleotides
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
US6444799B1 (en) 1997-12-31 2002-09-03 Csl Limited P. gingivalis polynucleotides and uses thereof
AUPP893999A0 (en) 1999-03-01 1999-03-25 Csl Limited Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis
US6833262B1 (en) * 1999-04-21 2004-12-21 University Of Georgia Research Foundation, Inc. Polypeptide having amidolytic activity for a serpin
WO2000067917A1 (en) 1999-05-12 2000-11-16 The General Hospital Corporation Permeabilizing biofilms
GB9913437D0 (en) 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
AUPQ485999A0 (en) 1999-12-24 2000-02-03 Csl Limited P. gingivalis antigenic composition
AUPQ718200A0 (en) 2000-04-28 2000-05-25 Csl Limited Porphyromonas gingivalis recombinant proteins and truncations
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
WO2002038742A2 (en) * 2000-11-08 2002-05-16 The University Of Georgia Research Foundation, Inc. Dipeptidylpeptidases and methods of use
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US20030083287A1 (en) 2000-11-30 2003-05-01 Burgess Nicola A. ginS
US20020192206A1 (en) * 2001-05-05 2002-12-19 Kozarov Emil V. Methods and compositions for angioproliferative disorder treatment
AUPR575401A0 (en) 2001-06-18 2001-07-12 Unisearch Limited Method of causing sloughing
JP2003192616A (ja) 2001-12-27 2003-07-09 Univ Nihon 歯周病用ｄｎａワクチン
JP2003286191A (ja) 2002-03-27 2003-10-07 Univ Nihon 歯周病用粘膜免疫ワクチン
US20070036734A1 (en) 2003-03-17 2007-02-15 Kirin Beer Kabushiki Kaisha Therapeutic agent for periodontal disease
CA2535799A1 (en) 2003-08-15 2005-03-03 University Of Florida Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
KR101178776B1 (ko) 2004-02-06 2012-09-07 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 치료학적 잠재성을 가진 어드헤신 및 어드헤신계 단백질을 동정하기 위한 컴퓨터 장치
US20070098649A1 (en) 2004-03-22 2007-05-03 The Board Of Trustees Of The University Of Illinois Method and composition for controlling oral pathogens
NZ554331A (en) 2004-09-23 2009-04-30 Univ Melbourne Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection
WO2008016385A2 (en) 2006-01-20 2008-02-07 The University Of Washington Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof
US20100092471A1 (en) 2006-06-27 2010-04-15 Oral Health Australia Pty Ltd Porphyromonas Gingivalis Polypeptides Useful in the Prevention of Periodontal Disease
WO2008124646A2 (en) 2007-04-06 2008-10-16 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Use of amyloid proteins as vaccine scaffolds
AU2008274906B2 (en) 2007-07-12 2013-11-07 Oral Health Australia Pty Ltd Biofilm treatment
CA2693717A1 (en) 2007-07-12 2009-01-15 Stuart Geoffrey Dashper Immunology treatment for biofilms
KR100948094B1 (ko) 2007-12-26 2010-03-16 주식회사 하이닉스반도체 데이터 출력 제어회로
KR101721904B1 (ko) 2008-08-29 2017-04-11 오럴 헬스 오스트레일리아 피티와이 엘티디 Ｐ．진지발리스 감염의 예방, 치료 및 진단

Also Published As

Publication number Publication date
EP1985625B1 (de) 2014-11-12
EP1985625A2 (de) 2008-10-29
CA2288234A1 (en) 1998-11-05
DE69840027D1 (de) 2008-10-30
NZ500451A (en) 2001-02-23
US20110268670A1 (en) 2011-11-03
US8841420B2 (en) 2014-09-23
EP1017714A4 (de) 2005-02-23
EP1985625A3 (de) 2009-02-18
DK1017714T3 (da) 2009-01-05
US7749502B2 (en) 2010-07-06
US8431688B2 (en) 2013-04-30
EP1017714A1 (de) 2000-07-12
US20080124284A1 (en) 2008-05-29
EP2246361A1 (de) 2010-11-03
CA2815903A1 (en) 1998-11-05
CA2639048A1 (en) 1998-11-05
KR20010020417A (ko) 2001-03-15
US7262271B2 (en) 2007-08-28
WO1998049192A1 (en) 1998-11-05
JP4276300B2 (ja) 2009-06-10
CA2639048C (en) 2012-12-11
CA2720332A1 (en) 1998-11-05
CA2288234C (en) 2008-11-18
KR100356040B1 (ko) 2002-10-18
AUPO652897A0 (en) 1997-05-29
ES2530510T3 (es) 2015-03-03
US20040005276A1 (en) 2004-01-08
CA2720332C (en) 2013-07-23
US20130309179A1 (en) 2013-11-21
EP1017714B1 (de) 2008-09-17
JP2002511847A (ja) 2002-04-16

Similar Documents

Publication Publication Date Title
ATE408618T1 (de) Synthetische peptidkonstrukte zur erkennung und behandlung von parodontose hervorgerufen durch porphyromonas gingivalis
MY101842A (en) Treatment of oral diseases.
DE69909818D1 (de) Pyrazolopyimidinon-derivate zur behandlung von impotenz
DE69932864D1 (de) Neue Fettsäureanaloge zur Behandlung des Bluthochdrucks
ATE516042T1 (de) Zusammensetzungen und verfahren zur behandlung und diagnose von tumoren
BR0015698A (pt) Composições e métodos para tratamento de doenças alérgicas
DE60116313D1 (de) Verbindungen zur behandlung der alzheimerischen krankheit
ATE522623T1 (de) Zusammensetzungen und verfahren zur behandlung und diagnose von lungentumoren
DE60124080D1 (de) Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
DE69940371D1 (de) Beta-glucan enthaltende zusammenstellungen und spezifische immunoglobuline
DE69636228D1 (de) Therapeutische Zusammensetzungen zur Behandlung von Lawsonia intracellularis Infektionen
HUP9801240A2 (en) Oral compositions
DE69807115T2 (de) Angiostatische verbindungen und zusammensetzungen zur behandlung des glc1a glaukoms
DE60132444D1 (de) Behandlung von reizkolon-syndrom oder -krankheit
DE60035693D1 (de) Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
DE69738770D1 (de) Porphyromonas gingivalis Antigene zur Diagnose und Behandlung von Periodontitis
DE602004028574D1 (de) Zusammensetzungen und verfahren zur behandlung des reizdarmsyndroms und von nichtulzeröser dyspepsie
DE60142786D1 (de) Zusammensetzungen und methoden zur behandlung von candidosen
DE69519040D1 (de) Zusammensetzung zur hygiene,prophylaxe und behandlung der mundhöhle
ATE137967T1 (de) Verwendung von ketorolac zur behandlung von periodontitis
ATE419348T1 (de) Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
ES2060280T3 (es) Composiciones orales.
DE69619542T2 (de) Bismut enthaltende zusammensetzungen zur verhütung und behandlung gastrointestinaler beschwerden
DE69626260D1 (de) Zusammensetzungen zur Vorbeugung und Behandlung von urogenitalen Störungen, die Wismut enthalten
DE69618617D1 (de) Wismuth enthaltende zusammensetzungen zur verhütung und behandlung gastrointestinaler beschwerden

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
REN Ceased due to non-payment of the annual fee