ATE407701T1 - Wässrige proteinformulierung mit verzögerter freigabe - Google Patents
Wässrige proteinformulierung mit verzögerter freigabeInfo
- Publication number
- ATE407701T1 ATE407701T1 AT02780626T AT02780626T ATE407701T1 AT E407701 T1 ATE407701 T1 AT E407701T1 AT 02780626 T AT02780626 T AT 02780626T AT 02780626 T AT02780626 T AT 02780626T AT E407701 T1 ATE407701 T1 AT E407701T1
- Authority
- AT
- Austria
- Prior art keywords
- delayed release
- protein formulation
- release protein
- aqueous delayed
- aqueous
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/037,369 US6818613B2 (en) | 2001-11-07 | 2001-11-07 | Aqueous sustained-release formulations of proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407701T1 true ATE407701T1 (de) | 2008-09-15 |
Family
ID=21893975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02780626T ATE407701T1 (de) | 2001-11-07 | 2002-10-25 | Wässrige proteinformulierung mit verzögerter freigabe |
Country Status (20)
Country | Link |
---|---|
US (3) | US6818613B2 (de) |
EP (1) | EP1441771B1 (de) |
JP (1) | JP2005514394A (de) |
CN (1) | CN1612752A (de) |
AR (1) | AR037260A1 (de) |
AT (1) | ATE407701T1 (de) |
AU (1) | AU2002343666B2 (de) |
BR (1) | BR0213992A (de) |
CA (1) | CA2465890A1 (de) |
CY (1) | CY1110271T1 (de) |
DE (1) | DE60228864D1 (de) |
DK (1) | DK1441771T3 (de) |
ES (1) | ES2312633T3 (de) |
HK (1) | HK1066468A1 (de) |
MX (1) | MXPA04004367A (de) |
MY (1) | MY136952A (de) |
PT (1) | PT1441771E (de) |
SI (1) | SI1441771T1 (de) |
TW (1) | TWI332845B (de) |
WO (1) | WO2003053471A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1311285E (pt) * | 2000-05-15 | 2005-06-30 | Hoffmann La Roche | Composicao farmaceutica liquida contendo um derivado de eritropoietina |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
DE602004013557D1 (de) * | 2003-02-28 | 2008-06-19 | Ares Trading Sa | FLÜSSIGE FORMULIERUNGEN DES TUMORNEKROSEFRAKTOR-BINDUNGSPROTEINs TBP-1 |
US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
EP1537876A1 (de) * | 2003-12-01 | 2005-06-08 | BioGeneriX AG | Formulierung einer Erythropoietin Lösung |
EP1720564A1 (de) * | 2004-02-20 | 2006-11-15 | Rinat Neuroscience Corp. | Verfahren zur behandlung von fettsucht oder diabetes mit nt-4/5 |
US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
KR101150242B1 (ko) | 2004-10-27 | 2012-06-13 | 유니버시티 오브 덴버 | 부신피질 자극 호르몬 유사체 및 관련 방법 |
CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
TW200808352A (en) * | 2006-02-02 | 2008-02-16 | Rinat Neuroscience Corp | Methods for treating unwanted weight loss or eating disorders by administering a TRKB agonist |
JP2009525319A (ja) * | 2006-02-02 | 2009-07-09 | ライナット ニューロサイエンス コーポレイション | trkBアンタゴニストを投与することにより肥満を治療する方法 |
WO2008121301A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human il-12 antibodies |
JP2010528647A (ja) | 2007-06-06 | 2010-08-26 | ドマンティス リミテッド | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
AU2008261212A1 (en) * | 2007-06-15 | 2008-12-18 | University Of Zurich | Treatment for Alzheimer' s disease |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
BRPI0821814A2 (pt) * | 2007-12-28 | 2015-06-16 | Heraeus Kulzer Gmbh | Uso e formulação tópica de eritropoietina para a cicatrização da pele |
US8357179B2 (en) * | 2009-07-08 | 2013-01-22 | Concentric Medical, Inc. | Vascular and bodily duct treatment devices and methods |
US20110009941A1 (en) * | 2009-07-08 | 2011-01-13 | Concentric Medical, Inc. | Vascular and bodily duct treatment devices and methods |
US8529596B2 (en) | 2009-07-08 | 2013-09-10 | Concentric Medical, Inc. | Vascular and bodily duct treatment devices and methods |
US8795317B2 (en) * | 2009-07-08 | 2014-08-05 | Concentric Medical, Inc. | Embolic obstruction retrieval devices and methods |
US8795345B2 (en) * | 2009-07-08 | 2014-08-05 | Concentric Medical, Inc. | Vascular and bodily duct treatment devices and methods |
US8357178B2 (en) * | 2009-07-08 | 2013-01-22 | Concentric Medical, Inc. | Vascular and bodily duct treatment devices and methods |
PT2637690T (pt) | 2010-11-11 | 2016-12-27 | Abbvie Biotechnology Ltd | Formulações líquidas de anticorpo anti-tnf-alfa de concentração elevada |
RU2599592C2 (ru) | 2011-02-04 | 2016-10-10 | Концентрик Медикал, Инк. | Устройство для извлечения эмболической окклюзии |
DK2726090T3 (da) | 2011-07-01 | 2020-01-20 | Biogen Ma Inc | Argininfri tnfr: fc-fusionspolypeptidsammensætninger |
TW201842929A (zh) * | 2017-05-03 | 2018-12-16 | 美商必治妥美雅史谷比公司 | 結合至肌肉生長抑制素以纖維連接蛋白為主之支架結構域蛋白質的穩定調配物 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3865801A (en) * | 1973-06-15 | 1975-02-11 | Atomic Energy Commission | Stabilization of urinary erythropoietin using sodium p-aminosalicylate and extracting into phenol |
EP0062827B1 (de) * | 1978-06-16 | 1986-07-23 | Kyowa Hakko Kogyo Co., Ltd | Benzamidderivate |
EP0090837A1 (de) | 1981-10-08 | 1983-10-12 | BERG, Kurt Frimann | Verfahren und zusammensetzung zum behandeln von kranken die an interferon empfindlichen krankheiten leiden |
JPH0686480B2 (ja) * | 1983-02-21 | 1994-11-02 | 雪印乳業株式会社 | エリスロポエチン製造用モノクローナル抗体 |
ES520813A0 (es) * | 1983-03-21 | 1984-05-16 | Prodes Sa | Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico. |
JPS604186A (ja) * | 1983-06-21 | 1985-01-10 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン化合物 |
DK173067B1 (da) | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
US4717717A (en) | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
US5457093A (en) | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
JP3249147B2 (ja) * | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
US6153407A (en) | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
IL192290A0 (en) | 1993-08-17 | 2008-12-29 | Kirin Amgen Inc | Erythropoietin analogs |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
CA2223583A1 (en) * | 1995-06-07 | 1996-12-19 | Alkermes Controlled Therapeutics Inc. | Device for releasing aggregation-stabilized, biologically active agent |
US5916597A (en) | 1995-08-31 | 1999-06-29 | Alkermes Controlled Therapeutics, Inc. | Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent |
CN1215340A (zh) | 1996-02-09 | 1999-04-28 | 安姆根有限公司 | 包含白介素-1抑制剂和控释聚合物的组合物 |
ATE341344T1 (de) | 1996-08-02 | 2006-10-15 | Ortho Mcneil Pharm Inc | Polypeptide mit einzelnem kovalent gebundenen n- terminalen wasserlöslichen polymer |
AU754619B2 (en) | 1997-07-23 | 2002-11-21 | Roche Diagnostics Gmbh | Production of erythropoietin by endogenous gene activation |
DK0902085T3 (da) | 1997-09-01 | 2004-04-05 | Aventis Pharma Gmbh | Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
US6548653B1 (en) | 1998-06-15 | 2003-04-15 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
PT1107791E (pt) | 1998-09-04 | 2007-07-06 | Scios Inc | Composições de hidrogel para a administração com libertação controlada de factores de crescimento |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
CO5160256A1 (es) | 1999-02-08 | 2002-05-30 | Zentaris Ag | Sales de peptidos farmaceuticamente activos para la liberacion sostenida y proceso de produccion |
MXPA01010208A (es) | 1999-04-09 | 2003-07-21 | Johnson & Johnson | Composiciones farmaceuticas de eritropoyetina. |
CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
-
2001
- 2001-11-07 US US10/037,369 patent/US6818613B2/en not_active Expired - Lifetime
-
2002
- 2002-10-25 DK DK02780626T patent/DK1441771T3/da active
- 2002-10-25 WO PCT/US2002/036300 patent/WO2003053471A1/en active IP Right Grant
- 2002-10-25 ES ES02780626T patent/ES2312633T3/es not_active Expired - Lifetime
- 2002-10-25 SI SI200230773T patent/SI1441771T1/sl unknown
- 2002-10-25 DE DE60228864T patent/DE60228864D1/de not_active Expired - Lifetime
- 2002-10-25 PT PT02780626T patent/PT1441771E/pt unknown
- 2002-10-25 CA CA002465890A patent/CA2465890A1/en not_active Abandoned
- 2002-10-25 JP JP2003554227A patent/JP2005514394A/ja not_active Ceased
- 2002-10-25 AU AU2002343666A patent/AU2002343666B2/en not_active Ceased
- 2002-10-25 MX MXPA04004367A patent/MXPA04004367A/es unknown
- 2002-10-25 BR BR0213992-8A patent/BR0213992A/pt not_active IP Right Cessation
- 2002-10-25 CN CNA028268903A patent/CN1612752A/zh active Pending
- 2002-10-25 AT AT02780626T patent/ATE407701T1/de active
- 2002-10-25 EP EP02780626A patent/EP1441771B1/de not_active Expired - Lifetime
- 2002-11-06 TW TW091132632A patent/TWI332845B/zh not_active IP Right Cessation
- 2002-11-06 AR ARP020104235A patent/AR037260A1/es unknown
- 2002-11-06 MY MYPI20024140A patent/MY136952A/en unknown
-
2003
- 2003-03-31 US US10/403,115 patent/US20030181361A1/en not_active Abandoned
-
2004
- 2004-08-18 US US10/920,803 patent/US7282480B2/en not_active Expired - Fee Related
- 2004-11-26 HK HK04109347.7A patent/HK1066468A1/xx not_active IP Right Cessation
-
2008
- 2008-12-10 CY CY20081101432T patent/CY1110271T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2002343666B2 (en) | 2007-04-05 |
MY136952A (en) | 2008-12-31 |
US20030181361A1 (en) | 2003-09-25 |
US20030148938A1 (en) | 2003-08-07 |
EP1441771A1 (de) | 2004-08-04 |
EP1441771B1 (de) | 2008-09-10 |
DE60228864D1 (de) | 2008-10-23 |
CN1612752A (zh) | 2005-05-04 |
US20050164927A1 (en) | 2005-07-28 |
AU2002343666A1 (en) | 2003-07-09 |
TW200303215A (en) | 2003-09-01 |
PT1441771E (pt) | 2008-10-29 |
TWI332845B (en) | 2010-11-11 |
JP2005514394A (ja) | 2005-05-19 |
DK1441771T3 (da) | 2009-01-05 |
HK1066468A1 (en) | 2005-03-24 |
BR0213992A (pt) | 2004-08-31 |
AR037260A1 (es) | 2004-11-03 |
CA2465890A1 (en) | 2003-07-03 |
US7282480B2 (en) | 2007-10-16 |
US6818613B2 (en) | 2004-11-16 |
ES2312633T3 (es) | 2009-03-01 |
CY1110271T1 (el) | 2015-01-14 |
WO2003053471A1 (en) | 2003-07-03 |
SI1441771T1 (sl) | 2009-02-28 |
MXPA04004367A (es) | 2005-05-16 |
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