ATE404245T1 - Pharmazeutische zusammensetzung enthaltend einen künstlichen sauerstoffträger - Google Patents
Pharmazeutische zusammensetzung enthaltend einen künstlichen sauerstoffträgerInfo
- Publication number
- ATE404245T1 ATE404245T1 AT04008419T AT04008419T ATE404245T1 AT E404245 T1 ATE404245 T1 AT E404245T1 AT 04008419 T AT04008419 T AT 04008419T AT 04008419 T AT04008419 T AT 04008419T AT E404245 T1 ATE404245 T1 AT E404245T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical composition
- composition containing
- osmotic pressure
- oxygen carrier
- artificial oxygen
- Prior art date
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002016 colloidosmotic effect Effects 0.000 abstract 2
- 239000003792 electrolyte Substances 0.000 abstract 2
- 239000002502 liposome Substances 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 239000003002 pH adjusting agent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003103875A JP2004307404A (ja) | 2003-04-08 | 2003-04-08 | 人工酸素運搬体を含む医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404245T1 true ATE404245T1 (de) | 2008-08-15 |
Family
ID=32866721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04008419T ATE404245T1 (de) | 2003-04-08 | 2004-04-07 | Pharmazeutische zusammensetzung enthaltend einen künstlichen sauerstoffträger |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7417118B2 (de) |
| EP (1) | EP1466649B1 (de) |
| JP (1) | JP2004307404A (de) |
| AT (1) | ATE404245T1 (de) |
| DE (1) | DE602004015660D1 (de) |
| ES (1) | ES2308061T3 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL273422B (en) | 2004-10-07 | 2022-07-01 | Transmedics Inc | Methods and systems for extracorporeal organ treatment |
| US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| JP2006232818A (ja) * | 2005-01-25 | 2006-09-07 | Nipro Corp | ポルフィリン金属錯体とアルブミンとの包接化合物 |
| EP1683529A1 (de) * | 2005-01-25 | 2006-07-26 | Nipro Corporation | Einschlussverbindung von Porphyrinmetallkomplex in Albumin |
| JP5038128B2 (ja) * | 2005-03-16 | 2012-10-03 | 日本ケミカルリサーチ株式会社 | 薬物運搬体 |
| US8647613B2 (en) | 2005-03-16 | 2014-02-11 | Jcr Pharmaceuticals Co., Ltd. | Drug carrier |
| US9078428B2 (en) * | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| DE102005031532A1 (de) * | 2005-07-01 | 2007-01-04 | Cytonet Gmbh & Co. Kg | Lagermedium für Zellen |
| TW200727900A (en) * | 2005-07-27 | 2007-08-01 | Yakult Honsha Kk | Aqueous solution preparation containing camptothecins |
| WO2007094511A1 (ja) * | 2006-02-15 | 2007-08-23 | Oxygenix Co., Ltd. | ヘモグロビンベース酸素運搬体を用いた動物細胞の培養方法 |
| IL181126A0 (en) * | 2006-11-01 | 2007-07-04 | S B Biotechnologies Ltd | Preparation of gold-containing nano-liposome particles and their use in medical therapy |
| EP2121017A2 (de) * | 2006-12-19 | 2009-11-25 | Nokad | Verfahren zur unterdrückung der expression von endogenem erythropoetin (epo) |
| JP2008195656A (ja) * | 2007-02-14 | 2008-08-28 | Nipro Corp | 人工酸素運搬体製剤 |
| US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| EP2058398A1 (de) | 2007-11-09 | 2009-05-13 | Nipro Corporation | Herstellung von rekombinantem humanem Hämoglobin mittels Pichia-Hefe |
| US8906855B2 (en) | 2007-12-22 | 2014-12-09 | Vivacelle Bio, Inc. | Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries |
| US8618056B2 (en) | 2007-12-22 | 2013-12-31 | Cuthbert O. Simpkins | Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries |
| US8063020B2 (en) | 2007-12-22 | 2011-11-22 | Simpkins Cuthbert O | Resuscitation fluid |
| US20090253712A1 (en) * | 2008-04-03 | 2009-10-08 | Semmelweis Egyetem | Aqueous solvent system for solubilization of azole compounds |
| US8420118B2 (en) | 2009-09-10 | 2013-04-16 | The Board Of Regents Of The University Of Oklahoma | Anionic lipids and lipid nano-structures and methods of producing and using same |
| US8808748B2 (en) * | 2010-04-20 | 2014-08-19 | Vindico NanoBio Technology Inc. | Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same |
| WO2012117688A1 (ja) | 2011-03-01 | 2012-09-07 | 学校法人中央大学 | ヘモグロビン－アルブミン複合体、並びに該複合体を含む人工血漿増量剤及び人工酸素運搬体 |
| DK2704560T3 (da) | 2011-04-14 | 2022-05-23 | Transmedics Inc | Organbehandlingsopløsning til maskinperfusion ex-vivo af donorlunger |
| DK3151663T3 (da) | 2014-06-02 | 2020-11-30 | Transmedics Inc | Ex vivo-organplejesystem |
| IL287607B (en) | 2014-09-29 | 2022-07-01 | Hutchinson Fred Cancer Res | Preparations, kits and methods for inducing acquired cellular resistance using induced stress proteins |
| CA2970117A1 (en) | 2014-12-12 | 2016-06-16 | Darren FREED | Apparatus and method for organ perfusion |
| ES2865392T7 (es) | 2015-04-16 | 2022-09-07 | The Research Foundation For The State Univ Of New York Univ At Buffalo | Nanoestructuras que comprenden conjugados de porfirina de cobalto-fosfolípido y etiquetas de polihistidina |
| US11207421B2 (en) | 2015-04-16 | 2021-12-28 | The Research Foundation For The State University Of New York | Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| US11213594B2 (en) | 2016-04-29 | 2022-01-04 | Poseida Therapeutics, Inc. | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids |
| WO2017201447A1 (en) | 2016-05-19 | 2017-11-23 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Reduced oxygen carriers and their use for the treatment of carboxyhemoglobinemia |
| WO2021230261A1 (ja) * | 2020-05-11 | 2021-11-18 | 国立大学法人大阪大学 | 刺激に応答して酸素を放出する系 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US120096A (en) * | 1871-10-17 | Improvement in making rubber stereotypes | ||
| GB1578776A (en) | 1976-06-10 | 1980-11-12 | Univ Illinois | Hemoglobin liposome and method of making the same |
| JPS6033367B2 (ja) | 1978-11-24 | 1985-08-02 | 株式会社ミドリ十字 | 酸素運搬輸液 |
| JPS57206622A (en) | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
| US4425334A (en) | 1982-04-02 | 1984-01-10 | The Regents Of The University Of California | Functional oxygen transport system |
| JPS58213779A (ja) | 1982-06-07 | 1983-12-12 | Hidetoshi Tsuchida | 疎水性アルキル基を有する鉄−テトラフエニルポルフイン錯体及び酸素吸脱着剤 |
| US4530926A (en) | 1982-06-29 | 1985-07-23 | The Green Cross Corporation | Perfluorotricyclic amines as oxygen carriers |
| JPS6137735A (ja) | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| JP3037994B2 (ja) | 1989-11-02 | 2000-05-08 | テルモ株式会社 | リポソーム表面への蛋白質吸着抑制剤 |
| JP3085963B2 (ja) | 1990-04-24 | 2000-09-11 | テルモ株式会社 | 人工血液 |
| US5589189A (en) * | 1994-09-14 | 1996-12-31 | Nexstar Pharmaceuticals, Inc. | Liposome dispersion |
| WO1998008500A1 (en) * | 1996-08-26 | 1998-03-05 | Board Of Regents, The University Of Texas System | Hypertonic arginine compositions and methods |
| JP3181276B2 (ja) | 1999-08-31 | 2001-07-03 | 科学技術振興事業団 | 樹枝状分岐構造を持つ両親媒性化合物 |
-
2003
- 2003-04-08 JP JP2003103875A patent/JP2004307404A/ja active Pending
-
2004
- 2004-04-07 DE DE602004015660T patent/DE602004015660D1/de not_active Expired - Lifetime
- 2004-04-07 EP EP04008419A patent/EP1466649B1/de not_active Expired - Lifetime
- 2004-04-07 US US10/819,352 patent/US7417118B2/en not_active Expired - Fee Related
- 2004-04-07 ES ES04008419T patent/ES2308061T3/es not_active Expired - Lifetime
- 2004-04-07 AT AT04008419T patent/ATE404245T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040258745A1 (en) | 2004-12-23 |
| DE602004015660D1 (de) | 2008-09-25 |
| EP1466649B1 (de) | 2008-08-13 |
| JP2004307404A (ja) | 2004-11-04 |
| US7417118B2 (en) | 2008-08-26 |
| ES2308061T3 (es) | 2008-12-01 |
| EP1466649A1 (de) | 2004-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |