ATE403749T1 - Ladungsmarker und auftrennung von nukleinsäuremolekülen - Google Patents
Ladungsmarker und auftrennung von nukleinsäuremolekülenInfo
- Publication number
- ATE403749T1 ATE403749T1 AT02724912T AT02724912T ATE403749T1 AT E403749 T1 ATE403749 T1 AT E403749T1 AT 02724912 T AT02724912 T AT 02724912T AT 02724912 T AT02724912 T AT 02724912T AT E403749 T1 ATE403749 T1 AT E403749T1
- Authority
- AT
- Austria
- Prior art keywords
- charge
- markers
- separation
- present
- nucleic acid
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- 239000000463 material Substances 0.000 abstract 3
- 150000001793 charged compounds Chemical class 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/777,430 US6780982B2 (en) | 1996-07-12 | 2001-02-06 | Charge tags and the separation of nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE403749T1 true ATE403749T1 (de) | 2008-08-15 |
Family
ID=25110238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02724912T ATE403749T1 (de) | 2001-02-06 | 2002-02-06 | Ladungsmarker und auftrennung von nukleinsäuremolekülen |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6780982B2 (de) |
| EP (1) | EP1385996B1 (de) |
| JP (1) | JP4364511B2 (de) |
| AT (1) | ATE403749T1 (de) |
| AU (1) | AU2002255511A1 (de) |
| CA (1) | CA2436746C (de) |
| DE (1) | DE60228074D1 (de) |
| WO (1) | WO2002063030A2 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6780982B2 (en) * | 1996-07-12 | 2004-08-24 | Third Wave Technologies, Inc. | Charge tags and the separation of nucleic acid molecules |
| US6322980B1 (en) * | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
| US7118860B2 (en) * | 1999-10-29 | 2006-10-10 | Stratagene California | Methods for detection of a target nucleic acid by capture |
| EP1252236A1 (de) * | 2000-02-02 | 2002-10-30 | Amersham Pharmacia Biotech UK Limited | Messreagenz |
| US7160735B2 (en) * | 2000-04-28 | 2007-01-09 | Monogram Biosciences, Inc. | Tagged microparticle compositions and methods |
| US7771929B2 (en) * | 2000-04-28 | 2010-08-10 | Monogram Biosciences, Inc. | Tag library compounds, compositions, kits and methods of use |
| US20030207300A1 (en) * | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
| US7537938B2 (en) * | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| WO2002095356A2 (en) | 2001-05-21 | 2002-11-28 | Aclara Biosciences, Inc. | Methods and compositions for analyzing proteins |
| US7041459B2 (en) | 2001-05-21 | 2006-05-09 | Monogram Biosciences, Inc. | Analyzing phosphorylated proteins |
| US7358052B2 (en) * | 2001-05-26 | 2008-04-15 | Monogram Biosciences, Inc. | Catalytic amplification of multiplexed assay signals |
| US20030153741A1 (en) * | 2002-02-08 | 2003-08-14 | Marek Kwiatkowski | Methods for separating oligonucleotides |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US20040161749A1 (en) * | 2003-01-24 | 2004-08-19 | Hall Jeff G. | 3' end tagged oligonucleotides |
| US20050130246A1 (en) * | 2003-10-27 | 2005-06-16 | Hossein Salimi-Moosavi | Detecting human anti-therapeutic antibodies |
| WO2006132588A1 (en) * | 2005-06-10 | 2006-12-14 | Quiatech Ab | Method for the purification of synthetic oligonucleotides containing one or several labels |
| US7713521B2 (en) * | 2005-08-12 | 2010-05-11 | Schering Corporation | MCP1 fusions |
| US7759062B2 (en) * | 2006-06-09 | 2010-07-20 | Third Wave Technologies, Inc. | T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection |
| US7772390B1 (en) | 2006-07-18 | 2010-08-10 | The Regents Of The University Of California | Lipid mediated nucleic acid synthesis |
| CA2718011C (en) | 2008-03-15 | 2015-05-19 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reaction using footprint probes |
| WO2010026488A2 (en) * | 2008-09-03 | 2010-03-11 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| US10759824B2 (en) | 2008-09-03 | 2020-09-01 | Quantumdx Group Limited | Design, synthesis and use of synthetic nucleotides comprising charge mass tags |
| JP5822726B2 (ja) * | 2008-09-03 | 2015-11-24 | クワンタムディーエックス・グループ・リミテッド | 電荷量タグを含む合成ヌクレオチドのデザイン、合成及び使用 |
| US9605302B2 (en) | 2008-09-03 | 2017-03-28 | Quantumdx Group Limited | Sensing strategies and methods for nucleic acid detection using biosensors |
| US8524217B2 (en) | 2010-05-11 | 2013-09-03 | Merck Sharp & Dohme Corp. | MCP1-Ig fusion variants |
| JP2013537239A (ja) * | 2010-09-21 | 2013-09-30 | ジーイー・ヘルスケア・リミテッド | 新規前駆体 |
| US8715937B2 (en) | 2010-11-15 | 2014-05-06 | Exact Sciences Corporation | Mutation detection assay |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| WO2013058868A2 (en) | 2011-10-18 | 2013-04-25 | Exact Sciences Corporation | Multiplexed kras mutation detection assay |
| WO2014158628A1 (en) | 2013-03-14 | 2014-10-02 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules |
| TWI646230B (zh) | 2013-08-05 | 2019-01-01 | 扭轉生物科技有限公司 | 重新合成之基因庫 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| JP6688318B2 (ja) | 2015-05-01 | 2020-04-28 | ジェン−プローブ・インコーポレーテッド | 多重侵入切断アッセイ |
| JP6982362B2 (ja) | 2015-09-18 | 2021-12-17 | ツイスト バイオサイエンス コーポレーション | オリゴ核酸変異体ライブラリーとその合成 |
| CN113604546A (zh) | 2015-09-22 | 2021-11-05 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| EP3400444A4 (de) * | 2016-01-04 | 2019-10-16 | QuantuMDx Group Limited | Entwurf, synthese und verwendung synthetischer nukleotide mit ladungsmassenmarkierungen |
| EP3464477A1 (de) | 2016-06-06 | 2019-04-10 | Sony Corporation | Ionische polymere mit fluoreszierenden oder gefärbten reportergruppen |
| AU2017315294B2 (en) | 2016-08-22 | 2023-12-21 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| CN110248724B (zh) | 2016-09-21 | 2022-11-18 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| EA201991262A1 (ru) | 2016-12-16 | 2020-04-07 | Твист Байосайенс Корпорейшн | Библиотеки вариантов иммунологического синапса и их синтез |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| US10894959B2 (en) | 2017-03-15 | 2021-01-19 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| KR20200047706A (ko) | 2017-09-11 | 2020-05-07 | 트위스트 바이오사이언스 코포레이션 | Gpcr 결합 단백질 및 이의 합성 방법 |
| US10894242B2 (en) | 2017-10-20 | 2021-01-19 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
| EP3735459A4 (de) | 2018-01-04 | 2021-10-06 | Twist Bioscience Corporation | Digitale informationsspeicherung auf dna-basis |
| AU2019228081A1 (en) * | 2018-03-02 | 2020-10-22 | Quantumcyte, Inc. | Methods, compositions, and devices for isolation and expression analysis of regions of interest from a tissue |
| CN112639130B (zh) | 2018-05-18 | 2024-08-09 | 特韦斯特生物科学公司 | 用于核酸杂交的多核苷酸、试剂和方法 |
| CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| SG11202109322TA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for glp1 receptor |
| CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| KR20220066151A (ko) | 2019-09-23 | 2022-05-23 | 트위스트 바이오사이언스 코포레이션 | Crth2에 대한 변이체 핵산 라이브러리 |
| CN116847858A (zh) * | 2021-02-16 | 2023-10-03 | 生物辐射实验室股份有限公司 | Sars cov-2感染性确定测定 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US5260433A (en) * | 1982-06-23 | 1993-11-09 | Enzo Diagnostics, Inc. | Saccharide specific binding system labeled nucleotides |
| US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US4775619A (en) | 1984-10-16 | 1988-10-04 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
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| US5427930A (en) | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
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| JP2775346B2 (ja) | 1992-04-03 | 1998-07-16 | アプライド バイオシステムズ，インコーポレイテッド | プローブ構成物および方法 |
| US5470705A (en) | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
| WO1995016910A1 (en) | 1993-12-17 | 1995-06-22 | Perkin-Elmer Corporation | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
| JP3175110B2 (ja) | 1994-02-07 | 2001-06-11 | オーキッド・バイオサイエンシーズ・インコーポレイテッド | リガーゼ／ポリメラーゼ媒体された単一ヌクレオチド多型のジェネティックビットアナリシスおよび遺伝子解析におけるその使用 |
| WO1996020287A2 (en) | 1994-12-23 | 1996-07-04 | Behringwerke Aktiengesellschaft | Detection of nucleic acids by target-catalyzed product formation |
| GB9504598D0 (en) | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US6090606A (en) | 1996-01-24 | 2000-07-18 | Third Wave Technologies, Inc. | Cleavage agents |
| AU731062B2 (en) | 1996-01-24 | 2001-03-22 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US6706471B1 (en) * | 1996-01-24 | 2004-03-16 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US6780982B2 (en) * | 1996-07-12 | 2004-08-24 | Third Wave Technologies, Inc. | Charge tags and the separation of nucleic acid molecules |
| EP2055781B1 (de) | 1996-11-29 | 2011-10-26 | Third Wave Technologies, Inc. | FEN-1-Endonucleasen, Mischungen und Spaltungsverfahren |
| AU2001278420A1 (en) | 2000-04-06 | 2001-11-07 | Epigenomics Ag | Diagnosis of diseases associated with dna repair |
-
2001
- 2001-02-06 US US09/777,430 patent/US6780982B2/en not_active Expired - Fee Related
-
2002
- 2002-02-06 AU AU2002255511A patent/AU2002255511A1/en not_active Abandoned
- 2002-02-06 DE DE60228074T patent/DE60228074D1/de not_active Expired - Lifetime
- 2002-02-06 AT AT02724912T patent/ATE403749T1/de not_active IP Right Cessation
- 2002-02-06 WO PCT/US2002/003423 patent/WO2002063030A2/en active Application Filing
- 2002-02-06 EP EP02724912A patent/EP1385996B1/de not_active Expired - Lifetime
- 2002-02-06 CA CA2436746A patent/CA2436746C/en not_active Expired - Fee Related
- 2002-02-06 JP JP2002562766A patent/JP4364511B2/ja not_active Expired - Fee Related
-
2004
- 2004-06-23 US US10/875,094 patent/US7384746B2/en not_active Expired - Fee Related
-
2008
- 2008-06-03 US US12/132,198 patent/US7678542B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050130179A1 (en) | 2005-06-16 |
| JP2005503114A (ja) | 2005-02-03 |
| AU2002255511A1 (en) | 2002-08-19 |
| JP4364511B2 (ja) | 2009-11-18 |
| CA2436746A1 (en) | 2002-08-15 |
| US20020128465A1 (en) | 2002-09-12 |
| EP1385996A2 (de) | 2004-02-04 |
| CA2436746C (en) | 2013-04-16 |
| US7678542B2 (en) | 2010-03-16 |
| US6780982B2 (en) | 2004-08-24 |
| WO2002063030A3 (en) | 2003-10-30 |
| DE60228074D1 (de) | 2008-09-18 |
| US7384746B2 (en) | 2008-06-10 |
| EP1385996B1 (de) | 2008-08-06 |
| WO2002063030A2 (en) | 2002-08-15 |
| US20090078574A1 (en) | 2009-03-26 |
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