ATE393237T1 - Mittel und verfahren zur in-vitro-bestimmung von camp - Google Patents

Mittel und verfahren zur in-vitro-bestimmung von camp

Info

Publication number
ATE393237T1
ATE393237T1 AT04819228T AT04819228T ATE393237T1 AT E393237 T1 ATE393237 T1 AT E393237T1 AT 04819228 T AT04819228 T AT 04819228T AT 04819228 T AT04819228 T AT 04819228T AT E393237 T1 ATE393237 T1 AT E393237T1
Authority
AT
Austria
Prior art keywords
camp
detectable labels
present
chimeric
camp binding
Prior art date
Application number
AT04819228T
Other languages
English (en)
Inventor
Viacheslav Nikolaev
Moritz Buenemann
Martin Lohse
Original Assignee
Bayerische Julius Maximilians
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayerische Julius Maximilians filed Critical Bayerische Julius Maximilians
Application granted granted Critical
Publication of ATE393237T1 publication Critical patent/ATE393237T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04819228T 2003-11-26 2004-11-26 Mittel und verfahren zur in-vitro-bestimmung von camp ATE393237T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03027311A EP1536020A1 (de) 2003-11-26 2003-11-26 Mittel und Verfahren zur optischen Bestimmung von cAMP in vitro und in vivo

Publications (1)

Publication Number Publication Date
ATE393237T1 true ATE393237T1 (de) 2008-05-15

Family

ID=34442896

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04819228T ATE393237T1 (de) 2003-11-26 2004-11-26 Mittel und verfahren zur in-vitro-bestimmung von camp

Country Status (8)

Country Link
US (1) US8889425B2 (de)
EP (2) EP1536020A1 (de)
JP (1) JP5296986B2 (de)
AT (1) ATE393237T1 (de)
CA (1) CA2547456C (de)
DE (1) DE602004013361T2 (de)
ES (1) ES2305906T3 (de)
WO (1) WO2005052186A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508014A (ja) 2003-10-10 2007-04-05 プロメガ　コーポレイション ルシフェラーゼバイオセンサー
US8236523B2 (en) 2004-08-23 2012-08-07 The Johns Hopkins University Camp reporters and high throughput assays
EP1791972A4 (de) * 2004-08-23 2009-12-02 Univ Johns Hopkins cAMP-REPORTER
EP2518082A3 (de) 2005-03-31 2013-03-13 Julius-Maximilians-Universität Würzburg Mittel zur Inhibierung von Antikörpern gegen den beta1-adrenergen Rezeptor
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
WO2007100618A2 (en) * 2006-02-23 2007-09-07 Atto Bioscience Novel cell-based phosphodiesterase assays
WO2007120522A2 (en) 2006-04-03 2007-10-25 Promega Corporation Permuted and nonpermuted luciferase biosensors
PT2197900E (pt) 2007-08-24 2012-10-24 Univ Wuerzburg J Maximilians Péptidos receptores duplamente cíclicos mutados que inibem anticorpos anti-receptor adrenérgico β1
EP2281046B1 (de) 2008-05-19 2012-01-25 Promega Corporation Luciferase-biosensoren für camp
MX2011007882A (es) 2009-01-27 2011-11-04 Univ Wuerzburg J Maximilians HOMOLOGOS-PEPTIDO NOVEDOSO PARA INHIBIR ANTICUERPOS ß1- ADRENOCEPTORES.
JP5586285B2 (ja) * 2009-03-18 2014-09-10 オリンパス株式会社 受容体相互作用検出方法およびサイクリックａｍｐセンサータンパク質
JP5806616B2 (ja) * 2009-04-17 2015-11-10 国立大学法人神戸大学 インスリン分泌増強剤のスクリーニング法
DE102010018878B4 (de) 2009-04-30 2013-09-26 Julius-Maximilians-Universität Würzburg Neue Zell-Linie zur Fluoreszenz-basierten Detektion von funktionell aktiven Antikörpern und Autoantikörpern gegen den Beta1-adrenergen Rezeptor
WO2011143339A1 (en) 2010-05-11 2011-11-17 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
US9290794B2 (en) 2010-05-11 2016-03-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
EP3056902B1 (de) * 2015-02-16 2020-04-01 Universite De Bordeaux Neuartige spannungsabhängige Ionenkanalfusionen und Verwendungsverfahren dafür
DE102015115640B4 (de) * 2015-09-16 2017-06-29 Stiftung Caesar Center Of Advanced European Studies And Research Verfahren zum Nachweis von Liganden vermittels Biosensoren
JP6885595B2 (ja) * 2015-12-04 2021-06-16 国立大学法人 東京大学 リガンド蛍光センサータンパク質とその使用
CN108642064B (zh) * 2018-05-21 2021-11-26 安徽农业大学 小麦种子休眠持续期基因TaCNGC-2A及其功能标记
WO2020102721A1 (en) * 2018-11-16 2020-05-22 Rapa Therapeutics, Llc Immune monitoring of neuro-inflammatory amyotrophic lateral sclerosis (als)
KR101991206B1 (ko) * 2018-11-29 2019-06-19 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR101991207B1 (ko) * 2018-11-29 2019-06-19 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR101996767B1 (ko) * 2018-11-29 2019-07-04 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
JP7493130B2 (ja) 2021-11-12 2024-05-31 Ｊｆｅスチール株式会社 案内装置、案内方法、計測装置、物体の製造設備、計測方法、物体の製造方法、物体の品質管理方法、作業装置、及び作業方法

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
WO2000049183A1 (en) * 1999-02-17 2000-08-24 Clontech Laboratories, Inc. FLUORESCENCE RESONANCE ENERGY TRANSFER DETECTION OF cAMP IN LIVING CELLS USING GFP VARIANTS
US6573059B1 (en) * 1999-06-04 2003-06-03 Rmf Dictagene S.A. Use of the regulatory subunit of the camp dependent protein kinase (PKA) from dictyostelium for camp measurements
US20040033943A1 (en) * 2000-07-03 2004-02-19 Strijbos Paul Johannes Leonardus Maria Hcn polypeptides and polynucleotides and their use in therapy
AU7777501A (en) 2000-08-14 2002-02-25 Michiyuki Matsuda Protein monitoring the activity of low-molecular weight gtp-binding protein
AU2001232219A1 (en) 2000-08-14 2001-06-06 Michiyuki Matsuda Protein monitoring the activity of small gtp-binding protein

Also Published As

Publication number Publication date
JP5296986B2 (ja) 2013-09-25
US20080286760A1 (en) 2008-11-20
EP1536020A1 (de) 2005-06-01
WO2005052186A1 (en) 2005-06-09
JP2007515160A (ja) 2007-06-14
CA2547456C (en) 2015-06-30
DE602004013361T2 (de) 2009-05-20
ES2305906T3 (es) 2008-11-01
CA2547456A1 (en) 2005-06-09
US8889425B2 (en) 2014-11-18
EP1687441A1 (de) 2006-08-09
EP1687441B1 (de) 2008-04-23
DE602004013361D1 (en) 2008-06-05

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