ATE390428T1 - Neue oripavinderivate und deren verwendungen als arzneimittel - Google Patents

Neue oripavinderivate und deren verwendungen als arzneimittel

Info

Publication number
ATE390428T1
ATE390428T1 AT02764501T AT02764501T ATE390428T1 AT E390428 T1 ATE390428 T1 AT E390428T1 AT 02764501 T AT02764501 T AT 02764501T AT 02764501 T AT02764501 T AT 02764501T AT E390428 T1 ATE390428 T1 AT E390428T1
Authority
AT
Austria
Prior art keywords
methyl
new
medicinal products
oripavine derivatives
cycloalkyl
Prior art date
Application number
AT02764501T
Other languages
German (de)
English (en)
Inventor
B Zhong
Z Gong
Y Wang
Y Liu
B Qin
Original Assignee
Inst Pharm & Toxicology Amms
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Pharm & Toxicology Amms filed Critical Inst Pharm & Toxicology Amms
Application granted granted Critical
Publication of ATE390428T1 publication Critical patent/ATE390428T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02764501T 2001-09-14 2002-09-13 Neue oripavinderivate und deren verwendungen als arzneimittel ATE390428T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB011421495A CN1233645C (zh) 2001-09-14 2001-09-14 新的东罂粟碱衍生物及其医药用途

Publications (1)

Publication Number Publication Date
ATE390428T1 true ATE390428T1 (de) 2008-04-15

Family

ID=4676657

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764501T ATE390428T1 (de) 2001-09-14 2002-09-13 Neue oripavinderivate und deren verwendungen als arzneimittel

Country Status (8)

Country Link
EP (1) EP1439179B1 (enExample)
JP (1) JP4532109B2 (enExample)
CN (1) CN1233645C (enExample)
AT (1) ATE390428T1 (enExample)
DE (1) DE60225827D1 (enExample)
MX (1) MXPA04002422A (enExample)
WO (1) WO2003024972A1 (enExample)
ZA (1) ZA200402733B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939920B (zh) * 2005-09-29 2011-08-31 中国人民解放军军事医学科学院毒物药物研究所 东罂粟碱类化合物及其医药用途
ES2329296T3 (es) * 2006-01-05 2009-11-24 Mallinckrodt, Inc. El uso de oripavina como material de partida para buprenorfina.
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
US8546572B2 (en) * 2008-03-31 2013-10-01 Sun Pharmaceutical Industries Limited Process for the preparation of morphinane analogues
AU2009300390B2 (en) * 2008-09-30 2015-05-14 SpecGx LLC Processes for the production of buprenorphine with reduced impurity formation
ES2462756T3 (es) 2008-09-30 2014-05-26 Mallinckrodt Llc Procedimientos de síntesis de alcaloides opiáceos con formación reducida de impurezas
NZ592005A (en) 2008-09-30 2013-03-28 Mallinckrodt Llc Process for the preparation of a N-alkylated ketomorphinan by selective catalytiC hydrogen transfer reduction
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
CA2738089C (en) 2008-09-30 2017-07-18 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
EP2342207B1 (en) 2008-09-30 2015-11-11 Mallinckrodt LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
TWI630208B (zh) * 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
CN102462680B (zh) * 2010-11-04 2016-08-03 中国人民解放军军事医学科学院毒物药物研究所 噻吩诺啡的长效缓释微球及其组合物和制备方法
CN102382118A (zh) * 2011-05-23 2012-03-21 浙江仙琚制药股份有限公司 一种7ɑ-乙酰基-6,14-乙基桥四氢蒂巴因的制备方法
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP3023427A1 (en) 2014-11-19 2016-05-25 Siegfried AG Improved method of manufacturing buprenorphine and analogues thereof from oripavine
EP3067357A1 (en) 2015-03-11 2016-09-14 Siegfried AG Method of manufacturing stereoisomers of buprenorphine and analogues thereof
GB2550566A (en) 2016-05-19 2017-11-29 Chapelglade Ltd Mattress evaluation system and method
CN108530452B (zh) * 2017-03-01 2023-02-03 泰州华元医药科技有限公司 高效抗成瘾药物
EP4613751A1 (en) 2024-03-07 2025-09-10 Siegfried AG Method of making chemical compounds useful for the synthesis of buprenorphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925723A (en) * 1960-09-05 1963-05-08 J F Macfarlan & Company Ltd Novel thebaine derivatives
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
DE2230154A1 (de) * 1972-06-21 1974-01-17 Boehringer Sohn Ingelheim N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
KR100204659B1 (ko) * 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물

Also Published As

Publication number Publication date
JP2005506985A (ja) 2005-03-10
WO2003024972A1 (en) 2003-03-27
CN1233645C (zh) 2005-12-28
EP1439179A4 (en) 2005-10-12
ZA200402733B (en) 2005-02-23
EP1439179B1 (en) 2008-03-26
WO2003024972A8 (en) 2004-06-17
JP4532109B2 (ja) 2010-08-25
MXPA04002422A (es) 2005-04-11
CN1408714A (zh) 2003-04-09
EP1439179A1 (en) 2004-07-21
DE60225827D1 (de) 2008-05-08

Similar Documents

Publication Publication Date Title
ATE390428T1 (de) Neue oripavinderivate und deren verwendungen als arzneimittel
AU2134402A (en) Antiviral agents
SE9904508D0 (sv) New compounds
NZ231062A (en) ((1,2 benzisoxazol-3-yl)piperidinyl alkyl)-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimdin-4-one derivatives and antipsychotic compositions
DE60000120D1 (de) Bicyclische Carbonyl-Indolverbindungen als entzündungshemmende/ analgetische Wirkstoffe und als COX-2 Inhibitoren
DE69529844D1 (de) Neue chinuclidin-derivate und diese enthaltende pharmazeutische präparate
HUT64336A (en) Methods for producing new thiazole-benzofurane derivatives and pharmaceutical preparatives containing them
HUP9801883A2 (hu) Farnezil-protein transzferáz enzim gátló piperazinszármazékok, előállításuk, alkalmazásuk, és a vegyületeket tartalmazó gyógyszerkészítmények
GB9902455D0 (en) Chemical compounds
ATE109149T1 (de) 3-pyrrolidinylthio-1-azabicyclo(3.2.0>-hept-2-e - 2-carbonsäureverbindungen.
DE60212110D1 (de) Triazaspiro (5.5) undecanderivate und arzneimittel, die diese derivate als wirkstoff enthalten
MXPA04003192A (es) Sales de acido succinico de 5, 7, 14-triazatetraciclo ?10.3.1.02,11.04,9? -hexadeca-2(11), 3, 5, 7, 9-pentaeno y composiciones farmacetucias de las mismas.
EP0915094A4 (en) MORPHINANE DERIVATIVES AND MEDICAL USE THEREOF
PL359415A1 (en) Oxadiazole derivatives having anticancer effects
GR3005990T3 (enExample)
CA2465871A1 (en) Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
IL99305A (en) 4-substituted dihydropyrido [4,3-d]pyrimidines their preparation and analgesic and topical antiinflammatory compositions containing them for the treatment of skin disorders
AU3231901A (en) Phenoxyalkylamine derivatives useful as opioid delta receptor agonists
HUT49879A (en) Process for producing new 1',2'-dihydrospiro square brackets open imidazolidine-4,4'(3'h)-quinoline square brackets closed derivatives and pharmaceutical compositions comprising these compounds as active ingredient
ATE170851T1 (de) Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten
HUP9901910A2 (hu) Orfanin FQ(OFQ) receptor agonista és/vagy antagonista di- vagy tri-aza-spiro[4,5]dekán-származékok, előállításuk és alkalmazásuk
ES2085234B1 (es) Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
IL143873A0 (en) Dry skin remedies
ATE208761T1 (de) Quinolin-derivate und diese enthaltende pharmazeutische zusammensetzungen
ZA872925B (en) Heterocyclic compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties