ATE390119T1 - Stabile benzimidazol zusammensetzungen - Google Patents
Stabile benzimidazol zusammensetzungenInfo
- Publication number
- ATE390119T1 ATE390119T1 AT00939023T AT00939023T ATE390119T1 AT E390119 T1 ATE390119 T1 AT E390119T1 AT 00939023 T AT00939023 T AT 00939023T AT 00939023 T AT00939023 T AT 00939023T AT E390119 T1 ATE390119 T1 AT E390119T1
- Authority
- AT
- Austria
- Prior art keywords
- enteric coating
- benzimidazole derivative
- solution
- range
- layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13060299A IL130602A0 (en) | 1999-06-22 | 1999-06-22 | Stable benzimidazole formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE390119T1 true ATE390119T1 (de) | 2008-04-15 |
Family
ID=11072951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00939023T ATE390119T1 (de) | 1999-06-22 | 2000-06-21 | Stabile benzimidazol zusammensetzungen |
Country Status (9)
Country | Link |
---|---|
US (4) | US7255878B1 (de) |
EP (1) | EP1187599B1 (de) |
AT (1) | ATE390119T1 (de) |
AU (1) | AU5423200A (de) |
CA (1) | CA2377605C (de) |
DE (1) | DE60038447T2 (de) |
ES (1) | ES2304349T3 (de) |
IL (2) | IL130602A0 (de) |
WO (1) | WO2000078284A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL130602A0 (en) | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
AU2002314306C1 (en) * | 2001-05-30 | 2008-12-04 | Euro-Celtique S.A. | Pharmaceutical composition containing stool softener such as polaxamer and enteric coated particles of bisacodyl |
WO2003103638A1 (en) * | 2002-06-07 | 2003-12-18 | Geneva Pharmaceuticals, Inc. | Stabilized pharmaceutical compositions containing benzimidazole compounds |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
EP1594479A1 (de) * | 2003-01-31 | 2005-11-16 | Ranbaxy Laboratories Limited | Stabile orale benzimidazol-zusammensetzungen und verfahren zu ihrer herstellung |
WO2004089333A2 (en) * | 2003-02-28 | 2004-10-21 | Cadila Healthcare Limited | A stable benzimidazole formulation |
TW200503783A (en) * | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
US20040213847A1 (en) * | 2003-04-23 | 2004-10-28 | Matharu Amol Singh | Delayed release pharmaceutical compositions containing proton pump inhibitors |
KR100983655B1 (ko) * | 2003-05-09 | 2010-09-24 | 동아제약주식회사 | 벤즈이미다졸 유도체의 경구용 제제 |
US20050181052A1 (en) * | 2004-02-17 | 2005-08-18 | Patel Satishkumar A. | Lansoprazole microtablets |
CA2582300A1 (en) * | 2004-10-05 | 2006-04-13 | Altana Pharma Ag | Oral pharmaceutical preparation comprising a proton pump antagonist and a basic excipient |
KR100570446B1 (ko) * | 2005-02-14 | 2006-04-12 | 지엘팜텍 주식회사 | 산 불안정성 약리활성물질 함유 장용성 경구용 제제 및 이의 제조방법 |
WO2009136398A2 (en) * | 2008-05-06 | 2009-11-12 | Dexcel Ltd | Stable benzimidazole formulation |
WO2012001705A2 (en) | 2010-06-29 | 2012-01-05 | Cadila Healthcare Limited | Pharmaceutical compositions of (r)-lansoprazole |
EP2776016B1 (de) | 2011-11-09 | 2019-02-20 | Capsugel Belgium NV | Säurebeständige bündelungslösung für zweiteilige säurebeständige hartkapseln |
CA2758556A1 (en) * | 2011-11-17 | 2013-05-17 | Pharmascience Inc. | Pharmaceutical composition of amphetamine mixed salts |
CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
CN106661130B (zh) * | 2014-08-27 | 2020-07-24 | 陶氏环球技术有限责任公司 | 不溶于丙酮的含量低的酯化纤维素醚 |
EP3288556A4 (de) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Oral zerfallende zusammensetzungen |
US20160331689A1 (en) * | 2015-05-12 | 2016-11-17 | SE Tylose USA, Inc. | Aqueous enteric coating composition |
EP3167880B1 (de) * | 2015-11-10 | 2019-06-19 | Capsugel Belgium NV | Säurebeständige bändelungs- oder dichtungslösung für säurebeständige zweiteilige hartkapseln |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN108434117A (zh) * | 2018-03-29 | 2018-08-24 | 成都通德药业有限公司 | 一种奥美拉唑肠溶胶囊的制备方法 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
ZA825384B (en) | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
SE8301182D0 (sv) | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
US5433959A (en) * | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
CA1327010C (en) | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
US6749864B2 (en) * | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
DK0519144T3 (da) | 1991-06-21 | 1998-03-23 | Ilsan Ilac Ve Hammaddeleri San | Ny galenisk proces for omeprazol indeholdende pellets |
US5225202A (en) * | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
FR2692146B1 (fr) | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
TW280770B (de) * | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
CA2170647C (en) * | 1994-07-08 | 2001-03-13 | Pontus John Arvid Bergstrand | Multiple unit tableted dosage form i |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
CH687810A5 (de) | 1995-05-24 | 1997-02-28 | Mepha Ag | Pelletformulierung mit Omeprazol. |
SK284291B6 (sk) | 1995-09-21 | 2005-01-03 | Pharma Pass L.L.C. | Farmaceutická kompozícia vo forme tabliet alebo mikrotabliet obsahujúca acidolabilný omeprazol a spôsob jej prípravy |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6245351B1 (en) * | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
DE19626045C2 (de) | 1996-06-28 | 1998-12-03 | Klinge Co Chem Pharm Fab | Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben |
US6623759B2 (en) * | 1996-06-28 | 2003-09-23 | Astrazeneca Ab | Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof |
US6248758B1 (en) * | 1997-03-13 | 2001-06-19 | Hexal Ag | Pharmaceutical antacid |
WO1998050019A1 (en) * | 1997-05-09 | 1998-11-12 | Sage Pharmaceuticals, Inc. | Stable oral pharmaceutical dosage forms |
SI9700186B (sl) * | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
US6602522B1 (en) * | 1997-11-14 | 2003-08-05 | Andrx Pharmaceuticals L.L.C. | Pharmaceutical formulation for acid-labile compounds |
US6174548B1 (en) * | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
WO1999027917A1 (de) * | 1997-11-28 | 1999-06-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Arzneimittelzubereitung in tabletten- oder pelletform für säurelabile wirkstoffe |
KR100627614B1 (ko) * | 1998-04-20 | 2006-09-25 | 에자이 가부시키가이샤 | 안정화된 벤즈이미다졸계 화합물 함유 조성물로 이루어지는 의약제제 |
ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
US6733778B1 (en) * | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
IL130602A0 (en) | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
US6262085B1 (en) * | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6326384B1 (en) * | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6268385B1 (en) * | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6228400B1 (en) * | 1999-09-28 | 2001-05-08 | Carlsbad Technology, Inc. | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
GB9923436D0 (en) | 1999-10-04 | 1999-12-08 | American Home Prod | Pharmaceutical compositions |
US6531158B1 (en) | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
DE10044299A1 (de) | 2000-09-07 | 2002-03-21 | Roehm Gmbh | Multipartikuläre Arzneiform und Verfahren zu ihrer Herstellung |
GB0114746D0 (en) | 2001-06-16 | 2001-08-08 | Boots Co Plc | Medicinal composition |
ES2333645T3 (es) * | 2001-06-22 | 2010-02-25 | Bend Research, Inc. | Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros. |
US20030235628A1 (en) | 2001-09-19 | 2003-12-25 | Rajneesh Taneja | Methods and pharmaceutical formulations for protecting pharmaceutical compounds from acidic environments |
US20050163846A1 (en) * | 2001-11-21 | 2005-07-28 | Eisai Co., Ltd. | Preparation composition containing acid-unstable physiologically active compound, and process for producing same |
DE10208335A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
FR2837100B1 (fr) | 2002-03-18 | 2004-07-23 | Flamel Tech Sa | Comprimes a bases de microcapsules a liberation modifiee |
WO2003103638A1 (en) | 2002-06-07 | 2003-12-18 | Geneva Pharmaceuticals, Inc. | Stabilized pharmaceutical compositions containing benzimidazole compounds |
US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
FR2841138B1 (fr) | 2002-06-25 | 2005-02-25 | Cll Pharma | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation |
CA2494716A1 (en) | 2002-08-02 | 2004-02-19 | Ratiopharm Gmbh | Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation |
US20040028737A1 (en) * | 2002-08-12 | 2004-02-12 | Kopran Research Laboratories Limited | Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same |
WO2004050068A1 (en) | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
WO2004089333A2 (en) | 2003-02-28 | 2004-10-21 | Cadila Healthcare Limited | A stable benzimidazole formulation |
US20040213847A1 (en) * | 2003-04-23 | 2004-10-28 | Matharu Amol Singh | Delayed release pharmaceutical compositions containing proton pump inhibitors |
-
1999
- 1999-06-22 IL IL13060299A patent/IL130602A0/xx unknown
-
2000
- 2000-06-21 DE DE60038447T patent/DE60038447T2/de not_active Expired - Lifetime
- 2000-06-21 WO PCT/IL2000/000364 patent/WO2000078284A1/en active IP Right Grant
- 2000-06-21 CA CA2377605A patent/CA2377605C/en not_active Expired - Lifetime
- 2000-06-21 US US10/018,992 patent/US7255878B1/en not_active Expired - Lifetime
- 2000-06-21 AU AU54232/00A patent/AU5423200A/en not_active Abandoned
- 2000-06-21 AT AT00939023T patent/ATE390119T1/de not_active IP Right Cessation
- 2000-06-21 ES ES00939023T patent/ES2304349T3/es not_active Expired - Lifetime
- 2000-06-21 EP EP00939023A patent/EP1187599B1/de not_active Expired - Lifetime
-
2001
- 2001-12-21 IL IL147232A patent/IL147232A/en active IP Right Revival
-
2007
- 2007-04-17 US US11/785,300 patent/US9023391B2/en active Active
-
2012
- 2012-04-26 US US13/456,411 patent/US20120244219A1/en not_active Abandoned
-
2016
- 2016-01-06 US US14/989,677 patent/US20160113878A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2304349T3 (es) | 2008-10-16 |
US20160113878A1 (en) | 2016-04-28 |
US9023391B2 (en) | 2015-05-05 |
IL147232A (en) | 2010-04-29 |
IL130602A0 (en) | 2000-06-01 |
US20070196485A1 (en) | 2007-08-23 |
DE60038447D1 (de) | 2008-05-08 |
EP1187599A4 (de) | 2004-05-19 |
WO2000078284A1 (en) | 2000-12-28 |
US20120244219A1 (en) | 2012-09-27 |
CA2377605C (en) | 2010-09-28 |
EP1187599A1 (de) | 2002-03-20 |
DE60038447T2 (de) | 2009-04-16 |
AU5423200A (en) | 2001-01-09 |
EP1187599B1 (de) | 2008-03-26 |
CA2377605A1 (en) | 2000-12-28 |
US7255878B1 (en) | 2007-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |