ATE384796T1 - Modifizierter tert-promotor mit verbesserter tumorspezifität und stärke sowie diesen enthaltender rekombinanter vektor - Google Patents
Modifizierter tert-promotor mit verbesserter tumorspezifität und stärke sowie diesen enthaltender rekombinanter vektorInfo
- Publication number
- ATE384796T1 ATE384796T1 AT04715577T AT04715577T ATE384796T1 AT E384796 T1 ATE384796 T1 AT E384796T1 AT 04715577 T AT04715577 T AT 04715577T AT 04715577 T AT04715577 T AT 04715577T AT E384796 T1 ATE384796 T1 AT E384796T1
- Authority
- AT
- Austria
- Prior art keywords
- recombinant vector
- strength
- vector containing
- containing same
- transcriptional regulatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2003-0012364A KR100523028B1 (ko) | 2003-02-27 | 2003-02-27 | 개선된 암세포 특이성과 활성을 가지는 사람 텔로미어역전사효소 프로모터 및 이를 포함하는 재조합 벡터 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE384796T1 true ATE384796T1 (de) | 2008-02-15 |
Family
ID=32923753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04715577T ATE384796T1 (de) | 2003-02-27 | 2004-02-27 | Modifizierter tert-promotor mit verbesserter tumorspezifität und stärke sowie diesen enthaltender rekombinanter vektor |
Country Status (7)
Country | Link |
---|---|
US (1) | US8067567B2 (de) |
EP (1) | EP1601772B1 (de) |
JP (1) | JP4327844B2 (de) |
KR (1) | KR100523028B1 (de) |
AT (1) | ATE384796T1 (de) |
DE (1) | DE602004011487T2 (de) |
WO (1) | WO2004076668A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7482158B2 (en) | 2004-07-01 | 2009-01-27 | Mathison Brian H | Composite polynucleic acid therapeutics |
KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
KR100792183B1 (ko) | 2006-05-29 | 2008-01-07 | 울산대학교 산학협력단 | 유전자 발현을 증가시키는 합성 hTERT 프로모터 |
CA2715080C (en) | 2007-09-28 | 2021-09-28 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
KR100969171B1 (ko) * | 2008-02-29 | 2010-07-14 | 연세대학교 산학협력단 | 종양 특이적 발현이 개선된 유전자전달체 |
CN103571954A (zh) * | 2013-10-28 | 2014-02-12 | 深圳市第二人民医院 | Tert启动子的单核苷酸多态性序列在检测泌尿系统肿瘤中的应用 |
EP3150706B1 (de) * | 2014-05-28 | 2019-07-10 | National University Corporation Okayama University | Konditionell replizierender adenovirus zur expression eines reic-gens |
AU2017375958A1 (en) | 2016-12-12 | 2019-07-04 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
KR20190138311A (ko) | 2017-04-21 | 2019-12-12 | 베이롤 칼리지 오브 메드신 | 종양용해성 바이러스요법 및 면역요법 |
AU2019322487B2 (en) | 2018-03-19 | 2024-04-18 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
KR102310819B1 (ko) * | 2019-01-11 | 2021-10-12 | 주식회사 진캐스트 | Tert 돌연변이 검출을 위한 dna 중합효소 및 이를 포함하는 키트 |
WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000003104A1 (en) | 1998-07-10 | 2000-01-20 | Owen Lyell Livingston | Modular walkway |
DK1147181T3 (da) * | 1999-02-04 | 2004-09-20 | Geron Corp | Telomerase revers transkriptase transskriptionelle regulatoriske sekvenser |
CN1195056C (zh) * | 2001-07-12 | 2005-03-30 | 钱其军 | 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法 |
EP1420803A1 (de) | 2001-08-08 | 2004-05-26 | Board Of Regents, The University Of Texas System | Verfahren zur verstärkung der expression aus einem zellspezifischen promotor |
-
2003
- 2003-02-27 KR KR10-2003-0012364A patent/KR100523028B1/ko active IP Right Grant
-
2004
- 2004-02-27 EP EP04715577A patent/EP1601772B1/de not_active Expired - Lifetime
- 2004-02-27 JP JP2006500654A patent/JP4327844B2/ja not_active Expired - Fee Related
- 2004-02-27 AT AT04715577T patent/ATE384796T1/de not_active IP Right Cessation
- 2004-02-27 DE DE602004011487T patent/DE602004011487T2/de not_active Expired - Lifetime
- 2004-02-27 US US10/547,233 patent/US8067567B2/en active Active
- 2004-02-27 WO PCT/KR2004/000427 patent/WO2004076668A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1601772A4 (de) | 2006-08-16 |
DE602004011487D1 (de) | 2008-03-13 |
KR20040077002A (ko) | 2004-09-04 |
JP4327844B2 (ja) | 2009-09-09 |
US8067567B2 (en) | 2011-11-29 |
EP1601772A1 (de) | 2005-12-07 |
US20070059287A1 (en) | 2007-03-15 |
DE602004011487T2 (de) | 2008-09-04 |
KR100523028B1 (ko) | 2005-10-20 |
WO2004076668A1 (en) | 2004-09-10 |
EP1601772B1 (de) | 2008-01-23 |
JP2006520585A (ja) | 2006-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE384796T1 (de) | Modifizierter tert-promotor mit verbesserter tumorspezifität und stärke sowie diesen enthaltender rekombinanter vektor | |
NO882341L (no) | Ekspresjon av humant proapolipoprotein a-i. | |
NZ553701A (en) | Composition comprising SC03-014 and SC03-022 antibodies against SARS-CoV | |
MXPA02000119A (es) | Elementos mezcladores estaticos apilados. | |
NO20074906L (no) | Polynukleotid som koder for et kimaert molekyl, vertcelle som uttrykker et kimaert molekyl og rekombinant vektor omfattende polynukleotidet | |
ATE266720T1 (de) | Replikativer virus gesteuert von dem promotor der reversen telomerase transkriptase zur behandlung von krebs | |
WO1999053040A3 (de) | Menschliche nukleinsäuresequenzen aus ovartumorgewebe | |
DE69840001D1 (de) | Methoden und zusammensetzungen zur induktion einer tumorspezifischen zytotoxizität | |
DE60235297D1 (de) | Auf lps-reagierendes chs1/beige-ähnliches anker-gen und therapeutische anwendungen davon | |
BR0209551A (pt) | Promotor de gene especìfico de folha de café | |
GB0418388D0 (en) | Cell therapy | |
TN2020000157A1 (en) | Binding molecule having neutralizing activity against middle east respiratory syndrome coronavirus | |
DK1339853T3 (da) | Isolerede luciferaser og deres anvendelse | |
MX2007004271A (es) | Enzimas involucradas en la sintesis de triterpenos. | |
PE20000759A1 (es) | Gen de la citocroma oxidasa de hidroquinona del tipo bd | |
DE59410221D1 (de) | Rekombinante chladosporium herbarum allergene | |
ATE494375T1 (de) | Frazzled nukleotidsequenzen, expressions- produkte, zusammensetzungen und verwendungen | |
WO2004074491A3 (en) | Expression in plants of antibodies against enterotoxigenic escherichia coli | |
HK1082510A1 (en) | Promoter to il-18bp, its preparation and use | |
TR200001683T2 (tr) | Nükleotid sıraları, şifrelenmiş proteinler ve onların kullanımları. | |
WO2001027287A3 (en) | Telomerase reverse transcriptase (tert) genes | |
AU1993201A (en) | Nucleic acid sequences of hyperplasia and tumours of the thyroid | |
WO1995006122A3 (de) | Recombinante alternaria alternata allergene | |
Denner-Ancona | Purification and characterization of vertebrate squalene epoxidase and oxidosqualene cyclase. | |
Shoemaker | Utility of photoaffinity labeling. I. Identification of nucleotide binding peptides within glucagon and glutamate dehydrogenase. II. Purification of a protein with aberrent nucleotide binding properties in Alzheimer's disease. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |