ATE381620T1 - Synthetische bidirektionale promotoren und deren verwendungen - Google Patents
Synthetische bidirektionale promotoren und deren verwendungenInfo
- Publication number
- ATE381620T1 ATE381620T1 AT04728627T AT04728627T ATE381620T1 AT E381620 T1 ATE381620 T1 AT E381620T1 AT 04728627 T AT04728627 T AT 04728627T AT 04728627 T AT04728627 T AT 04728627T AT E381620 T1 ATE381620 T1 AT E381620T1
- Authority
- AT
- Austria
- Prior art keywords
- promotors
- expression
- bidirectional
- synthetic bidirectional
- synthetic
- Prior art date
Links
- 230000002457 bidirectional effect Effects 0.000 title abstract 3
- 210000004102 animal cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46508003P | 2003-04-24 | 2003-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381620T1 true ATE381620T1 (de) | 2008-01-15 |
Family
ID=33310991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04728627T ATE381620T1 (de) | 2003-04-24 | 2004-04-21 | Synthetische bidirektionale promotoren und deren verwendungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8501464B2 (de) |
| EP (1) | EP1616012B1 (de) |
| JP (1) | JP2006524051A (de) |
| AT (1) | ATE381620T1 (de) |
| AU (1) | AU2004233315A1 (de) |
| CA (1) | CA2523138C (de) |
| DE (1) | DE602004010799T2 (de) |
| DK (1) | DK1616012T3 (de) |
| ES (1) | ES2298745T3 (de) |
| WO (1) | WO2004094642A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10000757B2 (en) | 2005-05-27 | 2018-06-19 | Ospedale San Raffaele S.R.L. | Gene vector |
| EP2188386A2 (de) * | 2007-09-17 | 2010-05-26 | Universite De Strasbourg | Verfahren für den nachweis oder die quantifizierung einer verkürzten mutation |
| DK2379722T3 (da) | 2008-12-16 | 2017-01-02 | C-Lecta Gmbh | Ekspressionsvektor |
| WO2010127166A2 (en) | 2009-04-30 | 2010-11-04 | The Regents Of The University Of California | Combination anti-hiv vectors, targeting vectors, and methods of use |
| US9719146B2 (en) * | 2009-09-09 | 2017-08-01 | General Electric Company | Composition and method for imaging stem cells |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| CN101851637B (zh) * | 2010-01-15 | 2011-12-14 | 中国农业科学院北京畜牧兽医研究所 | 一种制备同时表达多个基因的转基因动物的方法 |
| US20130109048A1 (en) * | 2010-07-09 | 2013-05-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for in-vitro monitoring of neuronal disorders and use thereof |
| US8945876B2 (en) | 2011-11-23 | 2015-02-03 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| US10370431B2 (en) | 2013-02-15 | 2019-08-06 | Bioverativ Therapeutics Inc. | Optimized factor VIII gene |
| CA2906970C (en) | 2013-03-21 | 2021-05-18 | Ospedale San Raffaele Srl | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| EP3283634B1 (de) * | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Rekombinantes adenovirus mit expression von zwei transgenen mit einem bidirektionalen promotor |
| WO2017096363A1 (en) * | 2015-12-04 | 2017-06-08 | Board Of Regents, The University Of Texas System | Reporter system for detecting and targeting activated cells |
| PT3411478T (pt) | 2016-02-01 | 2022-09-13 | Bioverativ Therapeutics Inc | Genes do fator viii otimizados |
| SG11201809096VA (en) * | 2016-04-20 | 2018-11-29 | Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas | Compositions and methods for enhanced gene expression of pklr |
| KR101864581B1 (ko) * | 2016-11-04 | 2018-07-13 | 국립암센터 | 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도 |
| EP3346001A1 (de) | 2017-01-06 | 2018-07-11 | TXCell | Monospezifische regulatorische t-zellpopulation mit zytotoxizität gegenüber b-zellen |
| WO2018127585A1 (en) | 2017-01-06 | 2018-07-12 | Txcell | Monospecific regulatory t cell population with cytotoxicity for b cells |
| CN111247251A (zh) | 2017-08-09 | 2020-06-05 | 比奥维拉迪维治疗股份有限公司 | 核酸分子及其用途 |
| JP7317023B2 (ja) | 2017-09-20 | 2023-07-28 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 新規抗ｈｌａ－ａ２抗体、およびその使用 |
| EP3697452A4 (de) | 2017-10-16 | 2021-11-24 | Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P. | Lentivirale vektoren zur verabreichung von pklr zur behandlung von pyruvatkinasemangel |
| WO2019118508A1 (en) * | 2017-12-12 | 2019-06-20 | The Trustees Of The University Of Pennsylvania | Genetically modified immune cells targeting ny-eso-1 and methods of use thereof |
| BR112020015228A2 (pt) | 2018-02-01 | 2020-12-29 | Bioverativ Therapeutics Inc. | Uso de vetores lentivirais que expressam fator viii |
| KR20210005879A (ko) | 2018-04-13 | 2021-01-15 | 상가모 테라퓨틱스 프랑스 | 인터류킨-23 수용체에 특이적인 키메라 항원 수용체 |
| SG11202101157VA (en) | 2018-08-09 | 2021-03-30 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| BR112021002579A2 (pt) | 2018-08-10 | 2021-05-11 | Sangamo Therapeutics France | novas construções de car compreendendo os domínios de tnfr2 |
| US20220047691A1 (en) * | 2018-10-17 | 2022-02-17 | Texas Tech University System | Multivalent Virus Like Particle Vaccines |
| GB201817821D0 (en) | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| EP3884056A1 (de) * | 2018-11-20 | 2021-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Zur behandlung des ipex-syndroms geeignete rekombinante vektoren |
| TW202039855A (zh) | 2018-12-06 | 2020-11-01 | 美商百歐維拉提夫治療公司 | 表現因子ｉｘ之慢病毒載體的用途 |
| TW202126284A (zh) | 2019-09-30 | 2021-07-16 | 美商百歐維拉提夫治療公司 | 慢病毒載體配製物 |
| EP3808766A1 (de) | 2019-10-15 | 2021-04-21 | Sangamo Therapeutics France | Interleukin-23-rezeptor-spezifischer chimärer antigen-rezeptor |
| US20230081343A1 (en) * | 2020-02-13 | 2023-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients |
| CN115916823A (zh) | 2020-03-20 | 2023-04-04 | 法国国家健康和医学研究院 | 人cd45rc特异的嵌合抗原受体及其用途 |
| TW202208619A (zh) | 2020-06-24 | 2022-03-01 | 美商百歐維拉提夫治療公司 | 用於純化病毒載體之方法 |
| BR112023001852A2 (pt) | 2020-08-07 | 2023-02-23 | Spacecraft Seven Llc | Terapia gênica com placofilina-2 (pkp2) usando vetor de aav |
| MX2023002221A (es) | 2020-08-23 | 2023-03-15 | Bioverativ Therapeutics Inc | Sistema de baculovirus modificado para produccion mejorada de adn de extremo cerrado (adnce). |
| CN113106091B (zh) * | 2021-03-04 | 2022-08-16 | 杭州师范大学 | 一种植物叶片高表达双向启动子及其应用 |
| CA3229323A1 (en) | 2021-08-23 | 2023-03-02 | Ajay MAGHODIA | Optimized factor viii genes |
| WO2023028440A2 (en) | 2021-08-23 | 2023-03-02 | Bioverativ Therapeutics Inc. | Baculovirus expression system |
| WO2023035002A1 (en) | 2021-09-03 | 2023-03-09 | Sangamo Therapeutics, Inc. | Mog-binding proteins and uses thereof |
| CA3232988A1 (en) | 2021-09-30 | 2023-04-06 | Bioverativ Therapeutics Inc. | Nucleic acids encoding factor viii polypeptides with reduced immunogenicity |
| WO2023182870A1 (ko) * | 2022-03-24 | 2023-09-28 | (주)셀레브레인 | 신규 재조합 벡터 및 이의 용도 |
| KR102632204B1 (ko) * | 2022-03-24 | 2024-02-02 | (주)셀레브레인 | 신규 재조합 벡터 및 이의 용도 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US6136597A (en) * | 1997-09-18 | 2000-10-24 | The Salk Institute For Biological Studies | RNA export element |
| CN1281512A (zh) | 1997-12-12 | 2001-01-24 | 昂尼克斯药物公司 | p53+肿瘤细胞的选择性杀伤和诊断 |
| EP1037669A4 (de) | 1997-12-12 | 2003-04-02 | Cell Genesys Inc | Therapeutische nutzung von lentiviralen vektoren |
| AU1905200A (en) | 1998-11-13 | 2000-06-05 | Cell Genesys, Inc. | A sensitive screening system for envelope-defective recombinant virus |
| WO2000029421A1 (en) | 1998-11-13 | 2000-05-25 | Cell Genesys, Inc. | Selection system for generating efficient packaging cells for lentiviral vectors |
| EP1173615A2 (de) | 1999-04-30 | 2002-01-23 | Advance Sentry Corporation | System und verfahren zum screening auf karzinome der nasalen pharynx |
| US6630324B1 (en) * | 1999-07-29 | 2003-10-07 | Baylor College Of Medicine | Aldehyde reductase bidirectional promoter and its use |
| US6780639B1 (en) * | 1999-08-24 | 2004-08-24 | Universite Libre De Bruxelles | Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization |
| AU2001278430A1 (en) | 2000-05-22 | 2001-12-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Systemic and cardiovascular transduction with lentiviral vectors |
| JP2003033179A (ja) * | 2001-07-05 | 2003-02-04 | Asahi Kasei Corp | 可逆的遺伝子導入ベクター |
| WO2003087294A2 (de) | 2002-04-15 | 2003-10-23 | Universitätsklinikum Hamburg-Eppendorf | Rekombinante virale vektoren zur tetracyclinregulierbaren genexpression |
-
2004
- 2004-04-21 DK DK04728627T patent/DK1616012T3/da active
- 2004-04-21 CA CA2523138A patent/CA2523138C/en not_active Expired - Lifetime
- 2004-04-21 EP EP04728627A patent/EP1616012B1/de not_active Expired - Lifetime
- 2004-04-21 US US10/554,181 patent/US8501464B2/en active Active
- 2004-04-21 JP JP2006507649A patent/JP2006524051A/ja active Pending
- 2004-04-21 DE DE602004010799T patent/DE602004010799T2/de not_active Expired - Lifetime
- 2004-04-21 WO PCT/IT2004/000227 patent/WO2004094642A2/en active IP Right Grant
- 2004-04-21 AT AT04728627T patent/ATE381620T1/de not_active IP Right Cessation
- 2004-04-21 AU AU2004233315A patent/AU2004233315A1/en not_active Abandoned
- 2004-04-21 ES ES04728627T patent/ES2298745T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK1616012T3 (da) | 2008-04-21 |
| US20060200869A1 (en) | 2006-09-07 |
| EP1616012B1 (de) | 2007-12-19 |
| CA2523138A1 (en) | 2004-11-04 |
| AU2004233315A1 (en) | 2004-11-04 |
| JP2006524051A (ja) | 2006-10-26 |
| ES2298745T3 (es) | 2008-05-16 |
| DE602004010799D1 (de) | 2008-01-31 |
| CA2523138C (en) | 2013-04-23 |
| WO2004094642A2 (en) | 2004-11-04 |
| WO2004094642A3 (en) | 2005-05-12 |
| US8501464B2 (en) | 2013-08-06 |
| DE602004010799T2 (de) | 2009-01-22 |
| EP1616012A2 (de) | 2006-01-18 |
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