ATE380202T1 - Interaktionssystem zur präsentation und entfernung von substanzen - Google Patents

Interaktionssystem zur präsentation und entfernung von substanzen

Info

Publication number
ATE380202T1
ATE380202T1 AT98922710T AT98922710T ATE380202T1 AT E380202 T1 ATE380202 T1 AT E380202T1 AT 98922710 T AT98922710 T AT 98922710T AT 98922710 T AT98922710 T AT 98922710T AT E380202 T1 ATE380202 T1 AT E380202T1
Authority
AT
Austria
Prior art keywords
presentation
substances
removal
interaction system
pmma
Prior art date
Application number
AT98922710T
Other languages
German (de)
English (en)
Inventor
Elke Bucha
Goetz Nowak
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE380202T1 publication Critical patent/ATE380202T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/401—Polymers based on the polymerisation of acrylic acid, e.g. polyacrylate
    • B01D71/4011—Polymethylmethacrylate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98922710T 1997-04-14 1998-04-14 Interaktionssystem zur präsentation und entfernung von substanzen ATE380202T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19715504A DE19715504C2 (de) 1997-04-14 1997-04-14 PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen

Publications (1)

Publication Number Publication Date
ATE380202T1 true ATE380202T1 (de) 2007-12-15

Family

ID=7826448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98922710T ATE380202T1 (de) 1997-04-14 1998-04-14 Interaktionssystem zur präsentation und entfernung von substanzen

Country Status (9)

Country Link
US (2) US6929955B2 (ja)
EP (2) EP0975680B1 (ja)
JP (1) JP4495258B2 (ja)
AT (1) ATE380202T1 (ja)
AU (1) AU7525498A (ja)
CA (1) CA2287469C (ja)
DE (2) DE19715504C2 (ja)
ES (1) ES2297886T3 (ja)
WO (1) WO1998046648A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845286A1 (de) * 1998-10-01 2000-04-27 Udo Dunzendorfer Beschichtete Trägermaterialien für Blut-, Plasma- oder Gewebewäsche und mit diesen Trägermaterialien ausgerüstete Säulen
DE19909584A1 (de) * 1999-03-04 2000-09-14 Haemosys Gmbh Trennverfahren
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
DE19918569A1 (de) * 1999-04-23 2000-12-07 Haemosys Gmbh Verfahren zur Diagnose von Krankheiten, pathologischen Zuständen und pathophysiologischen sowie physiologischen Messgrößen
DE19955341A1 (de) * 1999-11-17 2001-08-02 Haemosys Gmbh Blutkompatible Polymeroberflächen
EP1265639A1 (en) * 2000-03-20 2002-12-18 Knoll GmbH The use of anticoagulant agents in the extracorporeal treatment of blood
KR100345323B1 (ko) * 2000-04-24 2002-07-24 학교법인 포항공과대학교 나노 자성체 입자들을 포함하는 복합체
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
EP1443058A1 (en) * 2003-01-29 2004-08-04 Firmenich Sa Polymeric particles and fragrance delivery systems
DE10330900B4 (de) † 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
EG23584A (en) * 2003-11-11 2006-09-11 Ali Mokhtar Al-Hossary Amr Elimination of myoglobin from blood using an i v filter
US9561309B2 (en) * 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
DE102005001162A1 (de) * 2005-01-10 2006-07-20 Haemosys Gmbh Adsorptionssystem zur Entfernung von Viren und viralen Bestandteilen aus Flüssigkeiten, insbesondere aus Blut und Blutplasma
BRPI0618084A2 (pt) * 2005-11-14 2011-08-16 Univ Montreal composições farmacêuticas compreendendo aglutinantes poliméricos com ligações covalentes não hidrolisáveis e seus usos no tratamento da doença celìaca
DE102007033787A1 (de) 2007-07-09 2009-01-15 Aesculap Ag Gefäßprothese mit reduzierter Thrombogenität
DE102008000220A1 (de) * 2008-02-01 2009-08-13 ASCALON Gesellschaft für Innovation in der Medizintechnik m.b.H. Hohlfaser-Separationsmembranen und Verfahren zu ihrer Herstellung
EP2316931B1 (de) 2009-10-30 2016-12-28 Senova Gesellschaft für Biowissenschaft und Technik mbH Polymergekoppelte Peptidasen
EP2620162A1 (de) 2012-01-27 2013-07-31 Life Science Inkubator Enzym-Polymer-Konjugat zur Endotoxin-Detoxifikation
PT2892560T (pt) * 2012-09-06 2019-10-18 Adelaide Research&Innovation Pty Ltd Métodos e produtos para prevenção e/ou tratamento do cancro metastático

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1603393A (ja) * 1967-12-27 1971-04-13
JPS4867382A (ja) * 1971-12-06 1973-09-14
GB1484564A (en) * 1974-07-24 1977-09-01 Koch Light Labor Ltd Stable support material for enzyme insolubilisation
FR2321520A1 (fr) * 1975-08-22 1977-03-18 Rhone Poulenc Ind Latex de polymeres possedant des groupes-cn
DE2552510C3 (de) 1975-11-22 1981-02-19 Behringwerke Ag, 3550 Marburg Biologisch aktive Verbindungen und Verfahren zu ihrer Herstellung
DE2712344C2 (de) * 1977-03-21 1982-09-23 Hans Dr. 4803 Steinhagen Bünemann Löslicher Komplexbildner für die affinitätsspezifische Trennung von Nukleinsäuren
JPS57170263A (en) * 1981-04-14 1982-10-20 Kuraray Co Absorber for blood protein
US4575539A (en) * 1985-06-03 1986-03-11 E. R. Squibb & Sons, Inc. Drug delivery systems including novel interpenetrating polymer networks and method
JPH01310668A (ja) 1988-06-09 1989-12-14 Nikkiso Co Ltd 中空糸型血液浄化装置
CA1335142C (en) 1989-07-18 1995-04-04 Leon Edward St-Pierre Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
SE467309B (sv) * 1990-10-22 1992-06-29 Berol Nobel Ab Hydrofiliserad fast yta, foerfarande foer dess framstaellning samt medel daerfoer
AU668855B2 (en) * 1990-10-26 1996-05-23 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
JPH06256394A (ja) * 1991-08-13 1994-09-13 Kirin Amgen Delaware Inc 修飾インターロイキン６
DE4203965A1 (de) 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
DE4322884A1 (de) 1992-10-09 1994-04-14 Bayer Ag Biologisch aktive Polymere
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
ATE190633T1 (de) * 1993-04-27 2000-04-15 Cytotherapeutics Inc Membran aus einem acrylnitrilpolymer
FR2724461B1 (fr) * 1994-09-09 1996-12-20 Prolabo Sa Microsphere de latex biotinylee, procede de preparation d'une telle microsphere et utilisation en tant qu'agent de detection biologique
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19625642A1 (de) 1996-06-26 1998-01-08 Max Planck Gesellschaft Verfahren zur Herstellung einer Antidotausgangssubstanz für natürliche und synthetische Thrombininhibitoren

Also Published As

Publication number Publication date
JP4495258B2 (ja) 2010-06-30
CA2287469C (en) 2010-02-09
EP1921094A3 (de) 2009-06-24
AU7525498A (en) 1998-11-11
US6929955B2 (en) 2005-08-16
DE19715504A1 (de) 1998-10-15
WO1998046648A1 (de) 1998-10-22
US20050239131A1 (en) 2005-10-27
EP1921094A2 (de) 2008-05-14
EP0975680B1 (de) 2007-12-05
EP0975680A1 (de) 2000-02-02
ES2297886T3 (es) 2008-05-01
JP2001527539A (ja) 2001-12-25
US7494824B2 (en) 2009-02-24
DE19715504C2 (de) 2000-10-26
CA2287469A1 (en) 1998-10-22
DE59814134D1 (de) 2008-01-17
US20020028201A1 (en) 2002-03-07

Similar Documents

Publication Publication Date Title
DE59814134D1 (de) Interaktionssystem zur präsentation und entfernung von substanzen
ATE263579T1 (de) Abgabe von polyethylene glycol-molekül- konjugaten aus abbaubarem hydrogel
DE69636507D1 (de) Blutbehälter, sowie Instrument und Gerät zur Abgabe von Blut
ATE276762T1 (de) Stabile lyophilisierte pharmazeutische zubereitungen von mono- oder polykonalen antikörpern
DK0608313T3 (da) Formuleringer af blodkoagel-polymer-matrix ved afgivelse af osteogene proteiner
DE68909242D1 (de) Adhäsives mittel zur arzneistoffabgabe.
DE60117615D1 (de) Arzneimittelkombinationen (z.b. chlorpromazin und pentamidin) zur therapie von neoplastischen erkrankungen
DE69805772D1 (de) Stabilisierte mischung auf fibrinogenbasis
DE69624065D1 (de) Kompaktes gerät zur kultivierung von blut
DE69432582T2 (de) System zur Administration von Flüssigkeiten bei mehreren Patienten
DE69828895D1 (de) Alpha-aryl-n-alkylnitrone sowie diese enthaltende pharmazeutische zubereitungen
DE68928638T2 (de) Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung
DE69722388D1 (de) Nichtpolymere epoxyverbindungen zur vernetzung von biologischem gewebe und daraus hergestellte bioprothesen
DK0600866T3 (da) Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler
DE69833948D1 (de) Aktives system zur frühen zerstörung von schleppwirbeln
DE59610469D1 (de) Vorrichtung zur Verabreichung von Substanzen, insbesondere Inhalationspräparate
DE19681291T1 (de) Abwärtskompatibles Plattenlaufwerksystem und Wechselplatte
KR970702733A (ko) 활성물질의 방출 조절용 콜라겐 제제(collagen preparation the controlled release of active substances)
DE50003454D1 (de) Proteinenthaltende pharmazeutische zubereitung
DE69714451D1 (de) Prionbindende proteine und deren verwendungen
FR2730411B1 (fr) Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes
EP0821965A3 (de) Verwendung von (Meth)arcylsäure-Maleinsäure-Copolymeren zur Verbesserung der Permeabilität der Schleimhaut
ITMI942663A0 (it) Proteine ricche in idrossiprolina e formulazioni farmaceutiche e cosmetiche che le compongono
DE69835426D1 (de) Aktivierung von peptiden
DE69722623D1 (de) Verabreichungssystem von funktionellen wirkstoffen