ATE378341T1 - Verfahren zur formulierung antibiotischer verbindungen - Google Patents
Verfahren zur formulierung antibiotischer verbindungenInfo
- Publication number
- ATE378341T1 ATE378341T1 AT01934937T AT01934937T ATE378341T1 AT E378341 T1 ATE378341 T1 AT E378341T1 AT 01934937 T AT01934937 T AT 01934937T AT 01934937 T AT01934937 T AT 01934937T AT E378341 T1 ATE378341 T1 AT E378341T1
- Authority
- AT
- Austria
- Prior art keywords
- formulation
- carbapenem
- antibiotic compounds
- lyophilizing
- lyophilized
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- PLQZQEVQLGHUET-NUBCRITNSA-N C1C=CN2[C@H]1CC2=O.[Na] Chemical compound C1C=CN2[C@H]1CC2=O.[Na] PLQZQEVQLGHUET-NUBCRITNSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/029869 WO2001032172A1 (en) | 1999-10-29 | 2000-10-27 | Process for formulation of carbapenem antibiotic compositions |
| US09/698,808 US6548492B1 (en) | 1999-10-29 | 2000-10-27 | Process for formulation of carbapenem antibiotic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE378341T1 true ATE378341T1 (de) | 2007-11-15 |
Family
ID=24806736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01934937T ATE378341T1 (de) | 2000-10-27 | 2001-04-27 | Verfahren zur formulierung antibiotischer verbindungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6548492B1 (de) |
| EP (1) | EP1332145B1 (de) |
| JP (1) | JP2004512339A (de) |
| KR (1) | KR100756595B1 (de) |
| CN (1) | CN100384845C (de) |
| AT (1) | ATE378341T1 (de) |
| AU (2) | AU6107901A (de) |
| CA (1) | CA2426680C (de) |
| DE (1) | DE60131441T2 (de) |
| ES (1) | ES2295166T3 (de) |
| WO (1) | WO2002034750A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006290416B2 (en) * | 2005-09-15 | 2012-04-12 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of beta-lactam antibiotic |
| JP2009522288A (ja) * | 2005-12-28 | 2009-06-11 | アルザ コーポレイション | 安定な治療剤形 |
| US7455077B2 (en) * | 2007-01-10 | 2008-11-25 | Lundman Philip L | Inflatable plug with flange |
| CN101367815B (zh) * | 2007-06-28 | 2012-07-04 | 山东轩竹医药科技有限公司 | 六元环甲酰胺取代的巯基吡咯烷碳青霉烯化合物 |
| JPWO2009075309A1 (ja) * | 2007-12-12 | 2011-04-28 | 大日本住友製薬株式会社 | 製剤組成物 |
| CN101305964B (zh) * | 2008-05-26 | 2012-01-04 | 宜兴台玉环境工程设备有限公司 | 带润湿装置的泡药机 |
| EP2303225B1 (de) | 2008-06-11 | 2013-11-20 | Ranbaxy Laboratories Limited | Zusammensetzungen des Kohlenstoffdioxid Adduktes von Ertapenem und Polymorphe Formen des Mononatriumsalzes von Ertapenem |
| WO2012066492A1 (en) * | 2010-11-16 | 2012-05-24 | Ranbaxy Laboratories Limited | Processes for the preparation of carbapenem antibiotic composition |
| US8691803B2 (en) * | 2011-01-24 | 2014-04-08 | Savior Lifetec Corporation | Process for the preparation of antibiotic compounds |
| CN103181904B (zh) * | 2011-12-27 | 2016-01-20 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠冻干制剂及其制备方法 |
| CA2910421A1 (en) | 2013-05-07 | 2014-11-13 | Mcmaster University | Inhibitors of metallo-.beta.-lactamase-enzymes |
| CN109134469B (zh) * | 2013-12-31 | 2021-10-26 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠药物组合物及其制备方法 |
| CN104739828B (zh) * | 2013-12-31 | 2018-11-27 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠药物组合物及其制备方法 |
| KR101587420B1 (ko) * | 2014-08-20 | 2016-01-22 | 주식회사 대웅제약 | 에르타페넴-함유 동결건조제제의 제조방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| EP0814087A3 (de) * | 1996-05-08 | 1999-04-07 | Cypros Pharmaceutical Corporation | Teillyophilisierte Fructose-1,6-Diphosphat (FDP) für Einspritzung |
| UA62920C2 (en) | 1996-05-28 | 2004-01-15 | Merck & Co Inc | Carbapeneme antibiotic, a composition and a method for the preparation |
| US6297231B1 (en) | 1996-10-28 | 2001-10-02 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
| CA2268820A1 (en) * | 1996-10-28 | 1998-05-07 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
| BR9810135A (pt) * | 1997-06-16 | 2000-08-08 | Merck & Co Inc | Composto intermediário carbapenem estabilizado, e, processo para sintetizar um composto |
| US6180783B1 (en) | 1997-06-16 | 2001-01-30 | Merck & Co., Inc. | Stabilized carbapenem intermediates and improved process for carbapenem synthesis |
| CA2322658C (en) | 1998-03-02 | 2005-04-12 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| JP4854899B2 (ja) * | 1999-10-29 | 2012-01-18 | メルク・シャープ・エンド・ドーム・コーポレイション | カルバペネム系抗生物質組成物の処方方法 |
-
2000
- 2000-10-27 US US09/698,808 patent/US6548492B1/en not_active Expired - Lifetime
-
2001
- 2001-04-27 AU AU6107901A patent/AU6107901A/xx active Pending
- 2001-04-27 CA CA002426680A patent/CA2426680C/en not_active Expired - Lifetime
- 2001-04-27 KR KR1020037005798A patent/KR100756595B1/ko not_active Expired - Lifetime
- 2001-04-27 EP EP01934937A patent/EP1332145B1/de not_active Expired - Lifetime
- 2001-04-27 AU AU2001261079A patent/AU2001261079B2/en not_active Expired
- 2001-04-27 AT AT01934937T patent/ATE378341T1/de active
- 2001-04-27 ES ES01934937T patent/ES2295166T3/es not_active Expired - Lifetime
- 2001-04-27 WO PCT/US2001/013794 patent/WO2002034750A1/en not_active Ceased
- 2001-04-27 JP JP2002537740A patent/JP2004512339A/ja active Pending
- 2001-04-27 CN CNB018207294A patent/CN100384845C/zh not_active Expired - Lifetime
- 2001-04-27 DE DE60131441T patent/DE60131441T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004512339A (ja) | 2004-04-22 |
| EP1332145A4 (de) | 2004-07-28 |
| ES2295166T3 (es) | 2008-04-16 |
| AU6107901A (en) | 2002-05-06 |
| CN100384845C (zh) | 2008-04-30 |
| DE60131441D1 (de) | 2007-12-27 |
| EP1332145A1 (de) | 2003-08-06 |
| CA2426680A1 (en) | 2002-05-02 |
| CA2426680C (en) | 2009-08-25 |
| US6548492B1 (en) | 2003-04-15 |
| CN1481385A (zh) | 2004-03-10 |
| DE60131441T2 (de) | 2008-09-18 |
| WO2002034750A1 (en) | 2002-05-02 |
| KR100756595B1 (ko) | 2007-09-10 |
| AU2001261079B2 (en) | 2006-03-16 |
| EP1332145B1 (de) | 2007-11-14 |
| KR20030044045A (ko) | 2003-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1332145 Country of ref document: EP |
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| EEFA | Change of the company name |