DE60127948D1 - Verfahren zur herstellung von avermectinderivaten - Google Patents

Verfahren zur herstellung von avermectinderivaten

Info

Publication number
DE60127948D1
DE60127948D1 DE60127948T DE60127948T DE60127948D1 DE 60127948 D1 DE60127948 D1 DE 60127948D1 DE 60127948 T DE60127948 T DE 60127948T DE 60127948 T DE60127948 T DE 60127948T DE 60127948 D1 DE60127948 D1 DE 60127948D1
Authority
DE
Germany
Prior art keywords
dihydroavermectin
avermectin
medicine
preparation
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60127948T
Other languages
English (en)
Other versions
DE60127948T2 (de
Inventor
Hirofumi Endo
Hiroyuki Yamaguchi
Yutaka Kanda
Shinichi Hashimoto
Satoshi Omura
Haruo Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kitasato Institute
KH Neochem Co Ltd
Original Assignee
Kitasato Institute
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Institute, Kyowa Hakko Kogyo Co Ltd filed Critical Kitasato Institute
Publication of DE60127948D1 publication Critical patent/DE60127948D1/de
Application granted granted Critical
Publication of DE60127948T2 publication Critical patent/DE60127948T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60127948T 2000-02-24 2001-02-23 Verfahren zur herstellung von avermectinderivaten Expired - Fee Related DE60127948T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000047405 2000-02-24
JP2000047405 2000-02-24
PCT/JP2001/001381 WO2001062939A1 (fr) 2000-02-24 2001-02-23 Procede de production d'un derive d'avermectine

Publications (2)

Publication Number Publication Date
DE60127948D1 true DE60127948D1 (de) 2007-05-31
DE60127948T2 DE60127948T2 (de) 2008-01-17

Family

ID=18569657

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60127948T Expired - Fee Related DE60127948T2 (de) 2000-02-24 2001-02-23 Verfahren zur herstellung von avermectinderivaten

Country Status (7)

Country Link
US (1) US20040101936A1 (de)
EP (1) EP1270728B1 (de)
AT (1) ATE360086T1 (de)
AU (1) AU2001234164A1 (de)
CA (1) CA2402398A1 (de)
DE (1) DE60127948T2 (de)
WO (1) WO2001062939A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211985A1 (en) * 2000-07-18 2003-11-13 Zerhusen Bryan D. Novel proteins and nucleic acids encoding same
US7081213B2 (en) 2002-05-14 2006-07-25 Clariant Finance (Bvi) Limited Stabilizer mixtures for the protection of polymer substrates
WO2009126310A2 (en) * 2008-04-10 2009-10-15 Massachusetts Institute Of Technology Methods for identification and use of agents targeting cancer stem cells
WO2014074805A1 (en) 2012-11-08 2014-05-15 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
WO2015168255A1 (en) 2014-04-29 2015-11-05 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
CN113930407A (zh) * 2021-05-28 2022-01-14 湖北中农华威生物工程有限公司 一种水解酶及其在生物催化合成4″-甲氨基-5′-羟基-阿维菌素中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE129286T1 (de) * 1989-03-31 1995-11-15 Merck & Co Inc Klonierung von streptomyces avermitilis genen zur biosynthese von avermectin und verfahren zu ihrer verwendung.
JP3002347B2 (ja) * 1992-12-24 2000-01-24 社団法人北里研究所 ５−オキソ−エバーメクチン誘導体の直接醗酵法ならびにその生産微生物
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
US6197591B1 (en) * 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
CA2361040A1 (en) * 1999-01-27 2000-08-03 Kosan Biosciences, Inc. Synthesis of oligoketides
JP2000245457A (ja) * 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子

Also Published As

Publication number Publication date
EP1270728A1 (de) 2003-01-02
ATE360086T1 (de) 2007-05-15
CA2402398A1 (en) 2001-08-30
DE60127948T2 (de) 2008-01-17
AU2001234164A1 (en) 2001-09-03
US20040101936A1 (en) 2004-05-27
EP1270728A4 (de) 2004-11-24
EP1270728B1 (de) 2007-04-18
WO2001062939A1 (fr) 2001-08-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee