ATE356221T1 - Sequenzierung durch ligation kodierter adapter - Google Patents
Sequenzierung durch ligation kodierter adapterInfo
- Publication number
- ATE356221T1 ATE356221T1 AT97929757T AT97929757T ATE356221T1 AT E356221 T1 ATE356221 T1 AT E356221T1 AT 97929757 T AT97929757 T AT 97929757T AT 97929757 T AT97929757 T AT 97929757T AT E356221 T1 ATE356221 T1 AT E356221T1
- Authority
- AT
- Austria
- Prior art keywords
- encoded
- ligation
- protruding strands
- ligated
- target polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/659,453 US5846719A (en) | 1994-10-13 | 1996-06-06 | Oligonucleotide tags for sorting and identification |
| US68958796A | 1996-08-12 | 1996-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356221T1 true ATE356221T1 (de) | 2007-03-15 |
Family
ID=27097828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97929757T ATE356221T1 (de) | 1996-06-06 | 1997-06-02 | Sequenzierung durch ligation kodierter adapter |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0923650B1 (de) |
| JP (1) | JP4124377B2 (de) |
| CN (1) | CN1195872C (de) |
| AT (1) | ATE356221T1 (de) |
| AU (1) | AU733782B2 (de) |
| CA (1) | CA2256700A1 (de) |
| CZ (1) | CZ397998A3 (de) |
| DE (1) | DE69737450T2 (de) |
| HK (1) | HK1021206A1 (de) |
| HU (1) | HUP0003944A3 (de) |
| NO (1) | NO985698L (de) |
| PL (1) | PL331513A1 (de) |
| WO (1) | WO1997046704A1 (de) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| CN1146668C (zh) * | 1995-06-07 | 2004-04-21 | 林克斯治疗公司 | 用于分选和鉴定的寡核苷酸标记物 |
| GB9620769D0 (en) * | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Nucleic acid sequencing |
| US5888737A (en) * | 1997-04-15 | 1999-03-30 | Lynx Therapeutics, Inc. | Adaptor-based sequence analysis |
| CA2291180A1 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| US6265163B1 (en) | 1998-01-09 | 2001-07-24 | Lynx Therapeutics, Inc. | Solid phase selection of differentially expressed genes |
| JP3944996B2 (ja) | 1998-03-05 | 2007-07-18 | 株式会社日立製作所 | Ｄｎａプローブアレー |
| ATE423314T1 (de) | 1998-06-24 | 2009-03-15 | Illumina Inc | Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel |
| US6480791B1 (en) * | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| NO986133D0 (no) * | 1998-12-23 | 1998-12-23 | Preben Lexow | FremgangsmÕte for DNA-sekvensering |
| WO2000039333A1 (en) * | 1998-12-23 | 2000-07-06 | Jones Elizabeth Louise | Sequencing method using magnifying tags |
| WO2000060124A2 (en) * | 1999-04-06 | 2000-10-12 | Yale University | Fixed address analysis of sequence tags |
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US6544732B1 (en) | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| WO2000075373A2 (en) | 1999-05-20 | 2000-12-14 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
| US8080380B2 (en) | 1999-05-21 | 2011-12-20 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| JP2003527087A (ja) * | 1999-08-13 | 2003-09-16 | イェール・ユニバーシティ | バイナリーコード化配列タグ |
| ATE542916T1 (de) | 1999-08-18 | 2012-02-15 | Illumina Inc | Methoden zur erzeugung von oligonukleotidlösungen |
| AU3806701A (en) | 2000-02-07 | 2001-08-14 | Illumina Inc | Nucleic acid detection methods using universal priming |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| JP2003521252A (ja) | 2000-02-07 | 2003-07-15 | イルミナ インコーポレイテッド | ユニバーサルプライミングを用いる核酸検出方法 |
| EP1257668B1 (de) | 2000-02-16 | 2008-10-29 | Illumina, Inc. | Parallele genotypisierung mehrerer patientenproben |
| US7291460B2 (en) * | 2002-05-31 | 2007-11-06 | Verenium Corporation | Multiplexed systems for nucleic acid sequencing |
| CA2513985C (en) | 2003-01-21 | 2012-05-29 | Illumina Inc. | Chemical reaction monitor |
| ES2338654T5 (es) * | 2003-01-29 | 2017-12-11 | 454 Life Sciences Corporation | Amplificación de ácidos nucleicos en emulsión de perlas |
| GB0308852D0 (en) * | 2003-04-16 | 2003-05-21 | Lingvitae As | Method |
| WO2005010184A1 (ja) * | 2003-07-25 | 2005-02-03 | Takara Bio Inc. | 変異の検出方法 |
| GB0324456D0 (en) | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
| US7622281B2 (en) | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
| AU2006210553A1 (en) | 2005-02-01 | 2006-08-10 | Ab Advanced Genetic Analysis Corporation | Reagents, methods and libraries for bead-based sequencing |
| GB0524069D0 (en) | 2005-11-25 | 2006-01-04 | Solexa Ltd | Preparation of templates for solid phase amplification |
| WO2007091077A1 (en) * | 2006-02-08 | 2007-08-16 | Solexa Limited | Method for sequencing a polynucleotide template |
| JPWO2007097443A1 (ja) | 2006-02-20 | 2009-07-16 | 国立大学法人 北海道大学 | Ｄｎａ塩基配列を決定する方法 |
| JP2009538123A (ja) * | 2006-04-19 | 2009-11-05 | アプライド バイオシステムズ， エルエルシー | ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー |
| CN101495656B (zh) | 2006-06-07 | 2017-02-08 | 纽约哥伦比亚大学理事会 | 采用带修饰的核苷酸通过纳米通道进行dna序列测定 |
| US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
| US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| WO2012088341A2 (en) | 2010-12-22 | 2012-06-28 | Genia Technologies, Inc. | Nanopore-based single dna molecule characterization, identification and isolation using speed bumps |
| US9581563B2 (en) | 2011-01-24 | 2017-02-28 | Genia Technologies, Inc. | System for communicating information from an array of sensors |
| US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
| SG10201605049QA (en) * | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| EP2766498B1 (de) * | 2011-10-14 | 2019-06-19 | President and Fellows of Harvard College | Sequenzierung durch strukturanordnung |
| US11021737B2 (en) | 2011-12-22 | 2021-06-01 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
| EP4249605A3 (de) | 2011-12-22 | 2023-11-15 | President And Fellows Of Harvard College | Verfahren zum nachweis von analyten |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| CN102766689B (zh) * | 2012-04-17 | 2015-07-22 | 盛司潼 | 一种增加测序读长的测序方法 |
| CN104603286B (zh) * | 2012-04-24 | 2020-07-31 | Gen9股份有限公司 | 在体外克隆中分选核酸和多重制备物的方法 |
| WO2013169339A1 (en) * | 2012-05-10 | 2013-11-14 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| US9494554B2 (en) | 2012-06-15 | 2016-11-15 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
| US10138509B2 (en) | 2013-03-12 | 2018-11-27 | President And Fellows Of Harvard College | Method for generating a three-dimensional nucleic acid containing matrix |
| WO2014144883A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| JP6422193B2 (ja) * | 2013-09-30 | 2018-11-14 | キアゲン ゲーエムベーハー | Ｄｎａライブラリーの調製のためのｄｎａアダプター分子およびその生成法および使用 |
| US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
| CA2926138A1 (en) | 2013-10-23 | 2015-04-30 | Genia Technologies, Inc. | High speed molecular sensing with nanopores |
| US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
| PT3099779T (pt) * | 2014-01-28 | 2020-09-16 | Lanzatech New Zealand Ltd | Método para produzir um microorganismo recombinante |
| JP6723929B2 (ja) * | 2014-01-31 | 2020-07-15 | スウィフト バイオサイエンシズ， インク．Ｓｗｉｆｔ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． | Ｄｎａ基質を処理するための改善された方法 |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| CN106661636A (zh) * | 2014-09-05 | 2017-05-10 | 凯杰有限公司 | 衔接子连接的扩增子的制备 |
| US9890375B2 (en) * | 2014-09-12 | 2018-02-13 | Bgi Shenzhen Co., Limited | Isolated oligonucleotide and use thereof in nucleic acid sequencing |
| US20180044668A1 (en) * | 2014-10-14 | 2018-02-15 | Bgi Shenzhen Co., Limited | Mate pair library construction |
| EP3208336B1 (de) * | 2014-10-14 | 2019-11-13 | MGI Tech Co., Ltd. | Linkerelement und verfahren zur verwendung davon für den aufbau einer sequenzierungsbibliothek |
| US10221448B2 (en) | 2015-03-06 | 2019-03-05 | Pillar Biosciences Inc. | Selective amplification of overlapping amplicons |
| EP3130673B1 (de) * | 2015-08-13 | 2019-06-12 | Centrillion Technology Holdings Corporation | Bibliothekkonstruktion mit y-adaptern und schwindenden restriktionsstellen |
| AU2016349288A1 (en) | 2015-11-03 | 2018-05-31 | President And Fellows Of Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
| EP3390658B1 (de) | 2015-12-16 | 2022-08-03 | Standard BioTools Inc. | High-level-multiplexamplifikation |
| EP3426774A4 (de) | 2016-03-10 | 2019-08-14 | The Board of Trustees of the Leland Stanford Junior University | Transposase-vermittelte abbildung des zugänglichen genoms |
| WO2017189525A1 (en) | 2016-04-25 | 2017-11-02 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| AU2017295717B2 (en) | 2016-07-15 | 2021-06-24 | The Regents Of The University Of California | Methods of producing nucleic acid libraries |
| CN109923216A (zh) | 2016-08-31 | 2019-06-21 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| JP7239465B2 (ja) | 2016-08-31 | 2023-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 蛍光ｉｎ ｓｉｔｕ配列決定による検出のための核酸配列ライブラリの作製法 |
| US10550425B2 (en) * | 2016-11-14 | 2020-02-04 | Agilent Technologies, Inc. | Composition and method for improving signal-to-noise in hybridization to oligonucleotide arrays |
| CN110024037B (zh) * | 2016-11-30 | 2023-06-27 | 微软技术许可有限责任公司 | 经由连接的dna随机存取存储系统 |
| US11185568B2 (en) | 2017-04-14 | 2021-11-30 | President And Fellows Of Harvard College | Methods for generation of cell-derived microfilament network |
| CN107299151B (zh) * | 2017-08-28 | 2020-06-09 | 华中农业大学 | 用于鉴别稻米脂肪酸品质的dna分子标记及其应用 |
| JP7296969B2 (ja) | 2018-01-12 | 2023-06-23 | クラレット バイオサイエンス， エルエルシー | 核酸を解析するための方法および組成物 |
| AU2019280712A1 (en) | 2018-06-06 | 2021-01-07 | The Regents Of The University Of California | Methods of producing nucleic acid libraries and compositions and kits for practicing same |
| EP3836967A4 (de) | 2018-07-30 | 2022-06-15 | ReadCoor, LLC | Verfahren und systeme zur probenverarbeitung oder -analyse |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5102785A (en) * | 1987-09-28 | 1992-04-07 | E. I. Du Pont De Nemours And Company | Method of gene mapping |
| JPH02299598A (ja) * | 1989-04-14 | 1990-12-11 | Ro Inst For Molecular Genetics & Geneteic Res | 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法 |
| US5650274A (en) * | 1993-06-25 | 1997-07-22 | Hitachi, Ltd. | DNA analyzing method |
| GB9401200D0 (en) * | 1994-01-21 | 1994-03-16 | Medical Res Council | Sequencing of nucleic acids |
| US5552278A (en) * | 1994-04-04 | 1996-09-03 | Spectragen, Inc. | DNA sequencing by stepwise ligation and cleavage |
| US5604097A (en) * | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| WO1996041011A1 (en) * | 1995-06-07 | 1996-12-19 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
-
1997
- 1997-06-02 JP JP50075598A patent/JP4124377B2/ja not_active Expired - Lifetime
- 1997-06-02 DE DE69737450T patent/DE69737450T2/de not_active Expired - Lifetime
- 1997-06-02 EP EP97929757A patent/EP0923650B1/de not_active Expired - Lifetime
- 1997-06-02 HU HU0003944A patent/HUP0003944A3/hu not_active Application Discontinuation
- 1997-06-02 CZ CZ983979A patent/CZ397998A3/cs unknown
- 1997-06-02 CA CA002256700A patent/CA2256700A1/en not_active Abandoned
- 1997-06-02 WO PCT/US1997/009472 patent/WO1997046704A1/en active IP Right Grant
- 1997-06-02 CN CNB971971013A patent/CN1195872C/zh not_active Expired - Lifetime
- 1997-06-02 AT AT97929757T patent/ATE356221T1/de not_active IP Right Cessation
- 1997-06-02 PL PL97331513A patent/PL331513A1/xx unknown
- 1997-06-02 AU AU33740/97A patent/AU733782B2/en not_active Ceased
-
1998
- 1998-12-04 NO NO985698A patent/NO985698L/no not_active Application Discontinuation
-
1999
- 1999-12-04 HK HK99105687A patent/HK1021206A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003944A3 (en) | 2003-08-28 |
| EP0923650B1 (de) | 2007-03-07 |
| NO985698L (no) | 1999-02-08 |
| CZ397998A3 (cs) | 1999-07-14 |
| NO985698D0 (no) | 1998-12-04 |
| PL331513A1 (en) | 1999-07-19 |
| DE69737450D1 (de) | 2007-04-19 |
| CA2256700A1 (en) | 1997-12-11 |
| AU733782B2 (en) | 2001-05-24 |
| AU3374097A (en) | 1998-01-05 |
| JP4124377B2 (ja) | 2008-07-23 |
| HUP0003944A2 (en) | 2001-03-28 |
| WO1997046704A1 (en) | 1997-12-11 |
| CN1195872C (zh) | 2005-04-06 |
| CN1230226A (zh) | 1999-09-29 |
| JP2000515006A (ja) | 2000-11-14 |
| HK1021206A1 (en) | 2000-06-02 |
| DE69737450T2 (de) | 2007-11-29 |
| EP0923650A1 (de) | 1999-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |