ATE354636T1 - Verbesserte neurospora-wirtszellen zur herstellung rekombinanter proteine und methoden zu deren herstellung - Google Patents

Verbesserte neurospora-wirtszellen zur herstellung rekombinanter proteine und methoden zu deren herstellung

Info

Publication number
ATE354636T1
ATE354636T1 AT96939719T AT96939719T ATE354636T1 AT E354636 T1 ATE354636 T1 AT E354636T1 AT 96939719 T AT96939719 T AT 96939719T AT 96939719 T AT96939719 T AT 96939719T AT E354636 T1 ATE354636 T1 AT E354636T1
Authority
AT
Austria
Prior art keywords
methods
host cells
recombinant proteins
production
producing recombinant
Prior art date
Application number
AT96939719T
Other languages
English (en)
Inventor
W Dorsey Stuart
Original Assignee
Univ Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE354636T1 publication Critical patent/ATE354636T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT96939719T 1995-12-15 1996-11-12 Verbesserte neurospora-wirtszellen zur herstellung rekombinanter proteine und methoden zu deren herstellung ATE354636T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/573,020 US5776730A (en) 1995-12-15 1995-12-15 Neurospora hosts for the production of recombinant proteins, and methods for producing same

Publications (1)

Publication Number Publication Date
ATE354636T1 true ATE354636T1 (de) 2007-03-15

Family

ID=24290328

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96939719T ATE354636T1 (de) 1995-12-15 1996-11-12 Verbesserte neurospora-wirtszellen zur herstellung rekombinanter proteine und methoden zu deren herstellung

Country Status (11)

Country Link
US (1) US5776730A (de)
EP (1) EP0866848B1 (de)
JP (1) JPH11510065A (de)
AT (1) ATE354636T1 (de)
AU (1) AU721592B2 (de)
CA (1) CA2240149C (de)
DE (1) DE69636922T2 (de)
DK (1) DK0866848T3 (de)
ES (1) ES2283006T3 (de)
PT (1) PT866848E (de)
WO (1) WO1997022687A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811381A (en) * 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
US7883872B2 (en) * 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
EP1117808B1 (de) * 1998-10-06 2004-12-29 Mark Aaron Emalfarb Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
JP2008507294A (ja) * 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド 菌株遺伝子操作による改善されたタンパク質発現のための方法
EP2505651A3 (de) 2006-12-10 2013-01-09 Dyadic International, Inc. Pilzisolate mit reduzierter Proteaseaktivität
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2142651B1 (de) 2007-04-27 2013-05-22 Pfenex Inc. Schnellscreeningverfahren für bakterienwirte zur identifizierung bestimmter stämme mit verbessertem ertrag und/oder verbesserter qualität bei der expression heterologer proteine
WO2009033071A2 (en) * 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
DE102008013689A1 (de) * 2008-03-11 2009-09-17 Tesa Se Folienanordnung
CN104245919B (zh) 2012-01-05 2017-07-14 诺华股份有限公司 蛋白酶缺陷丝状真菌细胞及其使用方法
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
CA2916905A1 (en) 2013-07-10 2015-01-15 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
EP3172333B1 (de) 2014-07-21 2020-05-13 Glykos Finland Oy Herstellung von glycoproteinen mit säugerartigen n-glycanen in filamentösen pilzen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486533A (en) * 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4816405A (en) * 1984-10-24 1989-03-28 The Regents Of The University Of California Vectors for transformation by ascomycetes
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
ATE248925T1 (de) * 1988-01-05 2003-09-15 Roche Diagnostics Gmbh Verfahren zur herstellung von proteinen oder proteinhaltigen genprodukten
DE69636899T2 (de) * 1995-03-20 2007-10-31 Novozymes A/S Wirtszelle, die reduzierte mengen einer metalloprotease exprimiert und methoden zur verwendung dieser wirtszelle zur proteinproduktion
AU7112796A (en) * 1995-09-27 1997-04-17 Chiron Corporation Method of making a protease deficient host

Also Published As

Publication number Publication date
DK0866848T3 (da) 2007-05-21
US5776730A (en) 1998-07-07
EP0866848A4 (de) 2000-03-15
CA2240149C (en) 2009-06-30
JPH11510065A (ja) 1999-09-07
PT866848E (pt) 2007-03-30
CA2240149A1 (en) 1997-06-26
DE69636922D1 (de) 2007-04-05
WO1997022687A1 (en) 1997-06-26
DE69636922T2 (de) 2007-12-06
AU7681196A (en) 1997-07-14
EP0866848A1 (de) 1998-09-30
EP0866848B1 (de) 2007-02-21
AU721592B2 (en) 2000-07-06
ES2283006T3 (es) 2007-10-16

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