ATE34752T1 - Mit tritium radioaktiv markierte estradienderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung und ihre anwendung zum studium und zur bestimmung von steroiden in biologischen fluessigkeiten. - Google Patents
Mit tritium radioaktiv markierte estradienderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung und ihre anwendung zum studium und zur bestimmung von steroiden in biologischen fluessigkeiten.Info
- Publication number
- ATE34752T1 ATE34752T1 AT84401203T AT84401203T ATE34752T1 AT E34752 T1 ATE34752 T1 AT E34752T1 AT 84401203 T AT84401203 T AT 84401203T AT 84401203 T AT84401203 T AT 84401203T AT E34752 T1 ATE34752 T1 AT E34752T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- tritium
- study
- biological fluids
- determination
- Prior art date
Links
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 title abstract 3
- 229910052722 tritium Inorganic materials 0.000 title abstract 3
- 239000013060 biological fluid Substances 0.000 title abstract 2
- 238000013456 study Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 2
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000008569 process Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000002285 radioactive effect Effects 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000002158 estradienes Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8309812A FR2549067B1 (fr) | 1983-06-14 | 1983-06-14 | Derives estradieniques radioactifs marques au tritium, leur procede de preparation et leur application pour l'etude et le dosage radio-immunologique de steroides dans les fluides biologiques |
| EP84401203A EP0135400B1 (de) | 1983-06-14 | 1984-06-13 | Mit Tritium radioaktiv markierte Estradienderivate, Verfahren zu ihrer Herstellung, Zwischenprodukte zu ihrer Herstellung und ihre Anwendung zum Studium und zur Bestimmung von Steroiden in biologischen Flüssigkeiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE34752T1 true ATE34752T1 (de) | 1988-06-15 |
Family
ID=9289759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84401203T ATE34752T1 (de) | 1983-06-14 | 1984-06-13 | Mit tritium radioaktiv markierte estradienderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung und ihre anwendung zum studium und zur bestimmung von steroiden in biologischen fluessigkeiten. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4661295A (de) |
| EP (1) | EP0135400B1 (de) |
| JP (2) | JPS6011499A (de) |
| AT (1) | ATE34752T1 (de) |
| CA (2) | CA1222744A (de) |
| DE (1) | DE3471660D1 (de) |
| FI (1) | FI83785C (de) |
| FR (1) | FR2549067B1 (de) |
| NO (1) | NO162194C (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2785023B2 (ja) * | 1987-12-30 | 1998-08-13 | ルセル―ユクラフ | １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物 |
| DK0411733T3 (da) * | 1989-08-04 | 1999-06-28 | Schering Ag | 11-beta-aryl-gona-4,9-dien-3-oner |
| US5407928A (en) * | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
| EP0683172B1 (de) * | 1994-05-19 | 1997-08-13 | Akzo Nobel N.V. | 11,21-Bisphenyl-19-nor-pregnan Derivate |
| AU2019351004B2 (en) * | 2018-09-28 | 2023-09-14 | The Regents Of The University Of Michigan | Halogenated cholesterol analogues and methods of making and using same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2414515A1 (fr) * | 1978-01-11 | 1979-08-10 | Roussel Uclaf | Steroides marques au tritium, leur procede de preparation et leur application dans la synthese de derives de l'estrane marques au tritium |
| FR2430953A1 (fr) * | 1978-07-13 | 1980-02-08 | Roussel Uclaf | Nouveaux derives 3,20-dioxo 4,9-diene 21-hydroxyle, leur procede de preparation et leur application comme medicaments |
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
-
1983
- 1983-06-14 FR FR8309812A patent/FR2549067B1/fr not_active Expired
-
1984
- 1984-05-04 NO NO841798A patent/NO162194C/no unknown
- 1984-06-12 JP JP59119240A patent/JPS6011499A/ja active Pending
- 1984-06-13 EP EP84401203A patent/EP0135400B1/de not_active Expired
- 1984-06-13 CA CA000456496A patent/CA1222744A/fr not_active Expired
- 1984-06-13 FI FI842398A patent/FI83785C/fi not_active IP Right Cessation
- 1984-06-13 DE DE8484401203T patent/DE3471660D1/de not_active Expired
- 1984-06-13 AT AT84401203T patent/ATE34752T1/de not_active IP Right Cessation
- 1984-06-14 JP JP59120900A patent/JPS6034989A/ja active Pending
- 1984-06-14 US US06/620,454 patent/US4661295A/en not_active Expired - Fee Related
-
1987
- 1987-02-17 CA CA000529936A patent/CA1242695A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI842398L (fi) | 1984-12-15 |
| CA1242695A (fr) | 1988-10-04 |
| US4661295A (en) | 1987-04-28 |
| FR2549067A1 (fr) | 1985-01-18 |
| NO162194C (no) | 1989-11-22 |
| DE3471660D1 (en) | 1988-07-07 |
| FI842398A0 (fi) | 1984-06-13 |
| NO841798L (no) | 1984-12-17 |
| EP0135400B1 (de) | 1988-06-01 |
| FI83785C (fi) | 1991-08-26 |
| EP0135400A2 (de) | 1985-03-27 |
| FI83785B (fi) | 1991-05-15 |
| FR2549067B1 (fr) | 1985-12-27 |
| CA1222744A (fr) | 1987-06-09 |
| EP0135400A3 (en) | 1985-08-14 |
| NO162194B (no) | 1989-08-14 |
| JPS6011499A (ja) | 1985-01-21 |
| JPS6034989A (ja) | 1985-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |