ATE46346T1 - In stellung-17 durch einen nitromethylenrest substituierte steroidderivate und ihre verwendung zur herstellung biologisch aktiver produkte. - Google Patents

In stellung-17 durch einen nitromethylenrest substituierte steroidderivate und ihre verwendung zur herstellung biologisch aktiver produkte.

Info

Publication number
ATE46346T1
ATE46346T1 AT86200123T AT86200123T ATE46346T1 AT E46346 T1 ATE46346 T1 AT E46346T1 AT 86200123 T AT86200123 T AT 86200123T AT 86200123 T AT86200123 T AT 86200123T AT E46346 T1 ATE46346 T1 AT E46346T1
Authority
AT
Austria
Prior art keywords
carbon atoms
alkyl
nitromethylene
rest
manufacture
Prior art date
Application number
AT86200123T
Other languages
English (en)
Inventor
Derek Harold Richard Ba Barton
Fort Chateau
William Branks Motherwell
Zard Samir Zard
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of ATE46346T1 publication Critical patent/ATE46346T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT86200123T 1982-02-18 1983-02-15 In stellung-17 durch einen nitromethylenrest substituierte steroidderivate und ihre verwendung zur herstellung biologisch aktiver produkte. ATE46346T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8202681A FR2521567A1 (fr) 1982-02-18 1982-02-18 Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides
EP86200123A EP0192288B1 (de) 1982-02-18 1983-02-15 In Stellung-17 durch einen Nitromethylenrest substituierte Steroidderivate und ihre Verwendung zur Herstellung biologisch aktiver Produkte

Publications (1)

Publication Number Publication Date
ATE46346T1 true ATE46346T1 (de) 1989-09-15

Family

ID=9271110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86200123T ATE46346T1 (de) 1982-02-18 1983-02-15 In stellung-17 durch einen nitromethylenrest substituierte steroidderivate und ihre verwendung zur herstellung biologisch aktiver produkte.

Country Status (7)

Country Link
US (1) US4490296A (de)
EP (2) EP0087359B1 (de)
JP (2) JPS58152822A (de)
AT (1) ATE46346T1 (de)
DE (1) DE3379947D1 (de)
FR (1) FR2521567A1 (de)
HU (1) HU191199B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2033516T3 (es) * 1988-04-08 1993-03-16 Roussel-Uclaf Procedimiento para preparar 9 alfa-hidroxi-17 metileno-esteroides.
US5300523A (en) * 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
CN100345862C (zh) * 2004-03-12 2007-10-31 浙江医药股份有限公司新昌制药厂 甾类化合物的制备方法
CN104262442B (zh) * 2014-10-10 2016-01-20 湖南科瑞生物制药股份有限公司 黄体酮的制备方法
CN109796344B (zh) * 2018-12-20 2022-01-14 浙江工业大学 一种(e)-1,3-二苯基-4-硝基-1-丁烯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2383603A (en) * 1945-08-28 Condensation of nitroalkanes with
US3980681A (en) * 1969-11-21 1976-09-14 Peter Job Sykes Process for the preparation of 11-β-nitro-oxysteroids
HU162303B (de) * 1970-09-30 1973-01-29
JPS5113140B2 (de) * 1972-01-13 1976-04-26
JPS526612B2 (de) * 1972-05-20 1977-02-23
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto

Also Published As

Publication number Publication date
EP0087359A3 (en) 1984-08-22
JPH0559095A (ja) 1993-03-09
EP0192288A1 (de) 1986-08-27
DE3379947D1 (en) 1989-07-06
FR2521567A1 (fr) 1983-08-19
EP0087359A2 (de) 1983-08-31
HU191199B (en) 1987-01-28
FR2521567B1 (de) 1984-05-04
EP0087359B1 (de) 1989-05-31
EP0192288B1 (de) 1989-09-13
JPH0480889B2 (de) 1992-12-21
US4490296A (en) 1984-12-25
JPS58152822A (ja) 1983-09-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee