ATE342748T1 - Mikronadeln und verfahren zu ihrer herstellung - Google Patents

Mikronadeln und verfahren zu ihrer herstellung

Info

Publication number
ATE342748T1
ATE342748T1 AT02760947T AT02760947T ATE342748T1 AT E342748 T1 ATE342748 T1 AT E342748T1 AT 02760947 T AT02760947 T AT 02760947T AT 02760947 T AT02760947 T AT 02760947T AT E342748 T1 ATE342748 T1 AT E342748T1
Authority
AT
Austria
Prior art keywords
central axis
inner lumen
micro
body portion
needle
Prior art date
Application number
AT02760947T
Other languages
English (en)
Inventor
Goeran Stemme
Patrick Griss
Original Assignee
Bonsens Ab
Patrick Griss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonsens Ab, Patrick Griss filed Critical Bonsens Ab
Application granted granted Critical
Publication of ATE342748T1 publication Critical patent/ATE342748T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02760947T 2001-08-14 2002-08-14 Mikronadeln und verfahren zu ihrer herstellung ATE342748T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0102736A SE0102736D0 (sv) 2001-08-14 2001-08-14 Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles

Publications (1)

Publication Number Publication Date
ATE342748T1 true ATE342748T1 (de) 2006-11-15

Family

ID=20285040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02760947T ATE342748T1 (de) 2001-08-14 2002-08-14 Mikronadeln und verfahren zu ihrer herstellung

Country Status (9)

Country Link
US (2) US7258805B2 (de)
EP (1) EP1416996B1 (de)
JP (1) JP4348181B2 (de)
AT (1) ATE342748T1 (de)
AU (1) AU2002326256B2 (de)
CA (1) CA2457677C (de)
DE (1) DE60215516T2 (de)
SE (1) SE0102736D0 (de)
WO (1) WO2003015860A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
FR2862006B1 (fr) * 2003-11-12 2006-01-27 Univ Lille Sciences Tech Sources d'electronebulisation planaires sur le modele d'une plume de calligraphie et leur fabrication.
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
WO2005060621A2 (en) * 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US7819822B2 (en) * 2004-03-06 2010-10-26 Roche Diagnostics Operations, Inc. Body fluid sampling device
CN1929784B (zh) 2004-03-06 2010-09-29 霍夫曼-拉罗奇有限公司 体液采样设备
EP1732640A4 (de) 2004-03-12 2010-09-01 Agency Science Tech & Res Verfahren und formen zur verwendung bei der herstellung von mikronadeln mit seitenöffnungen
MXPA06010784A (es) 2004-03-26 2006-12-15 Unomedical As Dispositivo inyector para equipo de infusion.
EP1789127A2 (de) * 2004-08-05 2007-05-30 Apogee Technology, Inc. System und verfahren zur arzneiabgabe und mikrofluidische applikationen mit mikronadeln
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US20060040390A1 (en) * 2004-08-19 2006-02-23 Minor John S Jr Device, method, system, and program for intelligent in vivo cell-level chemical or genetic material delivery
SE0402100D0 (sv) 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
US8007466B2 (en) * 2004-11-18 2011-08-30 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
KR20070086306A (ko) 2004-12-10 2007-08-27 우노메디컬 에이/에스 주입기
EP1669100A1 (de) 2004-12-13 2006-06-14 Debiotech S.A. Micro-aiguilles
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006105146A2 (en) 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
PL1762259T3 (pl) 2005-09-12 2011-03-31 Unomedical As Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
EP1962679B1 (de) 2005-12-14 2012-04-11 Silex Microsystems AB Verfahren zur herstellung von mikronadeln und seine anwendungen
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
ES2326343T3 (es) 2005-12-23 2009-10-07 Unomedical A/S Dispositivo de administracion.
EP1988958B2 (de) 2006-02-28 2016-03-16 Unomedical A/S Einführungssystem für ein infusionsteil und infusionsteil mit nadelschutz
EP1998844A4 (de) * 2006-03-24 2017-03-01 3M Innovative Properties Company Verfahren zur herstellung von mikronadeln, mikronadelanordnung, vorlage und replikationswerkzeug
CA2653631A1 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter
EP2026861A1 (de) 2006-06-09 2009-02-25 Unomedical A/S Befestigungsauflage
DE102006028781A1 (de) 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
US8865288B2 (en) 2006-07-17 2014-10-21 University Of Utah Research Foundation Micro-needle arrays having non-planar tips and methods of manufacture thereof
US20080138581A1 (en) * 2006-07-17 2008-06-12 Rajmohan Bhandari Masking high-aspect aspect ratio structures
US7951300B2 (en) * 2006-07-17 2011-05-31 University Of Utah Research Foundation Water-scale needle array
JP4396776B2 (ja) 2006-07-27 2010-01-13 凸版印刷株式会社 マイクロニードルの製造方法
CN101500627B (zh) 2006-08-02 2012-03-14 优诺医疗有限公司 套管和输送装置
US20090326415A1 (en) * 2006-08-28 2009-12-31 Agency For Science ,Technology And Research Microneedles and methods for fabricating microneedles
US20090318833A1 (en) * 2006-09-18 2009-12-24 Agency For Science Technology And Research Needle Structures and Methods for Fabricating Needle Structures
EP1917990A1 (de) 2006-10-31 2008-05-07 Unomedical A/S Infusionsset
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20090011158A1 (en) * 2007-03-18 2009-01-08 Nanopass Technologies Ltd. Microneedle structures and corresponding production methods employing a backside wet etch
JP2010529891A (ja) * 2007-06-15 2010-09-02 ライフスキャン・インコーポレイテッド 可撓性カニューレ又は医療装置導管
DE202008017390U1 (de) 2007-06-20 2009-08-13 Unomedical A/S Katheter und Vorrichtung zum Herstellen eines solchen Katheters
JP2010531692A (ja) 2007-07-03 2010-09-30 ウノメディカル アクティーゼルスカブ 双安定均衡状態を持つ挿入器
KR20100062991A (ko) 2007-07-10 2010-06-10 우노메디컬 에이/에스 두 개의 스프링을 갖는 인서터
CA2694952A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
MY157968A (en) * 2007-11-14 2016-08-30 Mimos Berhad Method for fabricating microneedled and microneedle fabricated from the same
CN101970030B (zh) * 2007-12-17 2014-04-16 新世界药品有限公司 整合的真皮内递送、诊断和通讯系统
EP2072076A1 (de) * 2007-12-17 2009-06-24 Debiotech S.A. Herstellungsverfahren für Mikronadeln für den Außenbereich eines Flugzeugs
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
RU2010137844A (ru) 2008-02-13 2012-03-20 Уномедикал А/С (Dk) Уплотнение между канюльной частью и путем прохождения текучей среды
CA2715667A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
US20090301994A1 (en) * 2008-05-12 2009-12-10 Rajmohan Bhandari Methods for Wafer Scale Processing of Needle Array Devices
WO2009149197A2 (en) 2008-06-03 2009-12-10 University Of Utah Research Foundation High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same
NL2001718C2 (nl) 2008-06-24 2009-12-28 Needle Holding B V U Micronaald, micronaaldarray en fabricagewerkwijze daarvoor.
JP2012513224A (ja) 2008-12-22 2012-06-14 ウノメディカル アクティーゼルスカブ 接着剤パッドを含む医療デバイス
FI20095433A0 (fi) 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
EP2275164A1 (de) * 2009-07-15 2011-01-19 Debiotech S.A. Mikronadeln mit mehreren Kanälen
US9526885B1 (en) * 2009-07-29 2016-12-27 University Of South Florida Microneedles with sharpened tips and corresponding method of fabrication
BR112012002050A2 (pt) 2009-07-30 2016-05-17 Unomedical As dispositivo insersor com parte de movimento horizontal.
KR20120047896A (ko) 2009-08-07 2012-05-14 우노메디컬 에이/에스 센서와 하나 또는 그 이상의 캐뉼라들을 가진 전달 장치
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
EP2338557A1 (de) 2009-12-23 2011-06-29 Debiotech S.A. Lösliche Mikronadel
JP2013517889A (ja) * 2010-01-29 2013-05-20 ユーバイオメッド インク. マイクロニードル及びマイクロニードル装置
BR112012024635A2 (pt) 2010-03-30 2017-08-08 Unomedical As dispositivo médico
MX336139B (es) 2010-04-28 2016-01-08 Kimberly Clark Co Dispositivos medicos para la entrega de arn de interferencia corta.
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
KR101790815B1 (ko) 2010-04-28 2017-10-26 킴벌리-클라크 월드와이드, 인크. 세포성 상호작용이 향상된 나노패턴화 의료 기구
US9522263B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
JP5592147B2 (ja) * 2010-04-28 2014-09-17 ヤマハ株式会社 シリコンナノニードルおよびその製造方法
KR101180032B1 (ko) 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
EP2433663A1 (de) 2010-09-27 2012-03-28 Unomedical A/S Einführsystem
EP2436412A1 (de) 2010-10-04 2012-04-04 Unomedical A/S Sprinklerkanüle
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
KR101651809B1 (ko) * 2011-09-23 2016-08-29 에프. 호프만-라 로슈 아게 관통 요소의 마스크-에칭을 위한 방법
WO2013050277A1 (en) 2011-10-05 2013-04-11 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (de) 2011-10-19 2013-04-24 Unomedical A/S Infusionsschlauchsystem und Herstellungsverfahren
AU2012328037B2 (en) 2011-10-27 2017-11-02 Vivasor, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
EP2662110A1 (de) 2012-05-10 2013-11-13 Debiotech S.A. Vorrichtung und Methode für das Einsetzen von Nadeln
JP6269111B2 (ja) * 2013-01-31 2018-01-31 生化学工業株式会社 マイクロニードル及びマイクロニードルアレイ
CN105122135B (zh) 2013-02-12 2020-03-20 卡本有限公司 连续液体中间相打印
US10471699B2 (en) 2014-06-20 2019-11-12 Carbon, Inc. Three-dimensional printing with reciprocal feeding of polymerizable liquid
WO2016149152A1 (en) * 2015-03-13 2016-09-22 The University Of North Carolina At Chapel Hill Polymeric microneedles and rapid additive manufacturing of the same
CN107427406B (zh) 2015-04-13 2020-06-09 贝勒斯医疗有限公司 胶原刺激装置和方法
WO2017156347A1 (en) * 2016-03-09 2017-09-14 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
US11241563B2 (en) 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
JP6525017B2 (ja) * 2017-01-27 2019-06-05 大日本印刷株式会社 マイクロニードルデバイス
EP3603731A4 (de) * 2017-03-31 2020-07-15 Toppan Printing Co., Ltd. Vorrichtung für perkutane verabreichung
JP6304431B2 (ja) * 2017-06-01 2018-04-04 大日本印刷株式会社 マイクロニードルデバイス
EP3813809A1 (de) 2018-06-29 2021-05-05 Johnson & Johnson Consumer Inc. Vorrichtungen für dreidimensionale mikrofluidik zur abgabe von wirkstoffen
CN111228642A (zh) * 2020-02-12 2020-06-05 成都工业学院 一种中空微针阵列装置及制作方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
US6610235B1 (en) 1997-06-30 2003-08-26 The Regents Of The University Of California Method of fabricating epidermal abrasion device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815820D0 (en) * 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6406638B1 (en) * 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
ATE296575T1 (de) * 2000-01-21 2005-06-15 Instrumentarium Corp Herstellungsverfahren für eine medizinische elektrode
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
DE10065168A1 (de) 2000-12-23 2002-07-11 Lohmann Therapie Syst Lts Nadelpflaster mit vermindertem Infektionsrisiko
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6962772B2 (en) * 2002-12-27 2005-11-08 Industrial Technology Research Inst. Method for manufacturing 3-D high aspect-ratio microneedle array device
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays

Also Published As

Publication number Publication date
DE60215516T2 (de) 2007-08-30
EP1416996A1 (de) 2004-05-12
US7901387B2 (en) 2011-03-08
CA2457677C (en) 2009-10-06
US20040267205A1 (en) 2004-12-30
US20080039806A1 (en) 2008-02-14
JP2004538106A (ja) 2004-12-24
CA2457677A1 (en) 2003-02-27
SE0102736D0 (sv) 2001-08-14
EP1416996B1 (de) 2006-10-18
DE60215516D1 (de) 2006-11-30
US7258805B2 (en) 2007-08-21
JP4348181B2 (ja) 2009-10-21
AU2002326256B2 (en) 2008-05-22
WO2003015860A1 (en) 2003-02-27

Similar Documents

Publication Publication Date Title
ATE342748T1 (de) Mikronadeln und verfahren zu ihrer herstellung
DE602005009647D1 (de) Katheter
WO2005113047A3 (en) Hybrid micro guide catheter
EP1582138A3 (de) Medizinisches System mit Hüllrohr
AU2003223452A1 (en) Hypotube endoluminal device
WO2004096097A3 (en) Cutting stent and balloon
WO2002038052A3 (en) Steerable loop structure
DE60137803D1 (de) Vorrichtung zum Verabreichen von Arzneien in den Herzbeutel für Angiogenesis
ATE370761T1 (de) Katheter mit seitenwandlumenausgang und herstellungsverfahren
GB2370506B (en) Catheter tip
WO2006002343A3 (en) Method and medical device for rapid and accurate entry through soft tissue and bone
DE60013092D1 (de) Ballonkatheter für den Magen mit verbesserter Ballonorientierung
DE60034807D1 (de) Bolusspitzengestaltung für einen mehrlumigen katheter
EP1892009A4 (de) Endoskop-behandlungsinstrument und endoskop-behandlungsinstrumentenvorrichtung
WO2007019539A3 (en) Methods and devices for delivering agents across biological barriers
WO2005056078A3 (en) Facilitated balloon catheter exchange
ATE409063T1 (de) Ballonkatheter mit einer weichen spitze
WO2006110474A3 (en) Stents with profiles for gripping a balloon catheter and molds for fabricating stents
ATE484246T1 (de) Biegeweiche vorrichtung zum einbringen einer medizinischen vorrichtung in den körper
WO2005035018A3 (en) Lancing device end cap with rocking-actuated surface features
DE60034269D1 (de) Flüssigkeitsausstosskopf, dessen Herstellungsverfahren und mikroelektromechanische Vorrichtung
ATE458454T1 (de) Implantierbare sprachprothese und implantationsinstrument
EP1413676A4 (de) Verfahren zur herstellung von hohlfaserformkörpern, hohlfaserformkörper und vorrichtung zu deren herstellung
WO2006008602A3 (en) Tracheostomy apparatus
WO2005044116A3 (en) Cutting device for blunt needle

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties