ATE342748T1 - Mikronadeln und verfahren zu ihrer herstellung - Google Patents
Mikronadeln und verfahren zu ihrer herstellungInfo
- Publication number
- ATE342748T1 ATE342748T1 AT02760947T AT02760947T ATE342748T1 AT E342748 T1 ATE342748 T1 AT E342748T1 AT 02760947 T AT02760947 T AT 02760947T AT 02760947 T AT02760947 T AT 02760947T AT E342748 T1 ATE342748 T1 AT E342748T1
- Authority
- AT
- Austria
- Prior art keywords
- central axis
- inner lumen
- micro
- body portion
- needle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0102736A SE0102736D0 (sv) | 2001-08-14 | 2001-08-14 | Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE342748T1 true ATE342748T1 (de) | 2006-11-15 |
Family
ID=20285040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02760947T ATE342748T1 (de) | 2001-08-14 | 2002-08-14 | Mikronadeln und verfahren zu ihrer herstellung |
Country Status (9)
Country | Link |
---|---|
US (2) | US7258805B2 (de) |
EP (1) | EP1416996B1 (de) |
JP (1) | JP4348181B2 (de) |
AT (1) | ATE342748T1 (de) |
AU (1) | AU2002326256B2 (de) |
CA (1) | CA2457677C (de) |
DE (1) | DE60215516T2 (de) |
SE (1) | SE0102736D0 (de) |
WO (1) | WO2003015860A1 (de) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL134997A0 (en) * | 2000-03-09 | 2001-05-20 | Yehoshua Yeshurun | Health care system based on micro device |
US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US20040051019A1 (en) | 2002-09-02 | 2004-03-18 | Mogensen Lasse Wesseltoft | Apparatus for and a method of adjusting the length of an infusion tube |
DK200201823A (da) | 2002-11-26 | 2004-05-27 | Maersk Medical As | Forbindelsesstykke for en slangeforbindelse |
US7415299B2 (en) * | 2003-04-18 | 2008-08-19 | The Regents Of The University Of California | Monitoring method and/or apparatus |
FR2862006B1 (fr) * | 2003-11-12 | 2006-01-27 | Univ Lille Sciences Tech | Sources d'electronebulisation planaires sur le modele d'une plume de calligraphie et leur fabrication. |
US7998119B2 (en) * | 2003-11-18 | 2011-08-16 | Nano Pass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
WO2005060621A2 (en) * | 2003-11-21 | 2005-07-07 | The Regents Of The University Of California | Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles |
US8551391B2 (en) | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
US7819822B2 (en) * | 2004-03-06 | 2010-10-26 | Roche Diagnostics Operations, Inc. | Body fluid sampling device |
CN1929784B (zh) | 2004-03-06 | 2010-09-29 | 霍夫曼-拉罗奇有限公司 | 体液采样设备 |
EP1732640A4 (de) | 2004-03-12 | 2010-09-01 | Agency Science Tech & Res | Verfahren und formen zur verwendung bei der herstellung von mikronadeln mit seitenöffnungen |
MXPA06010784A (es) | 2004-03-26 | 2006-12-15 | Unomedical As | Dispositivo inyector para equipo de infusion. |
EP1789127A2 (de) * | 2004-08-05 | 2007-05-30 | Apogee Technology, Inc. | System und verfahren zur arzneiabgabe und mikrofluidische applikationen mit mikronadeln |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
US20060040390A1 (en) * | 2004-08-19 | 2006-02-23 | Minor John S Jr | Device, method, system, and program for intelligent in vivo cell-level chemical or genetic material delivery |
SE0402100D0 (sv) | 2004-08-30 | 2004-08-30 | Bonsens Ab | Molded micro-needles |
US7132054B1 (en) * | 2004-09-08 | 2006-11-07 | Sandia Corporation | Method to fabricate hollow microneedle arrays |
US8007466B2 (en) * | 2004-11-18 | 2011-08-30 | Nanopass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
KR20070086306A (ko) | 2004-12-10 | 2007-08-27 | 우노메디컬 에이/에스 | 주입기 |
EP1669100A1 (de) | 2004-12-13 | 2006-06-14 | Debiotech S.A. | Micro-aiguilles |
US7985199B2 (en) | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
WO2006105146A2 (en) | 2005-03-29 | 2006-10-05 | Arkal Medical, Inc. | Devices, systems, methods and tools for continuous glucose monitoring |
PL1762259T3 (pl) | 2005-09-12 | 2011-03-31 | Unomedical As | Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową |
USD655807S1 (en) | 2005-12-09 | 2012-03-13 | Unomedical A/S | Medical device |
EP1962679B1 (de) | 2005-12-14 | 2012-04-11 | Silex Microsystems AB | Verfahren zur herstellung von mikronadeln und seine anwendungen |
WO2007075614A1 (en) * | 2005-12-21 | 2007-07-05 | 3M Innovative Properties Company | Microneedle devices |
ES2326343T3 (es) | 2005-12-23 | 2009-10-07 | Unomedical A/S | Dispositivo de administracion. |
EP1988958B2 (de) | 2006-02-28 | 2016-03-16 | Unomedical A/S | Einführungssystem für ein infusionsteil und infusionsteil mit nadelschutz |
EP1998844A4 (de) * | 2006-03-24 | 2017-03-01 | 3M Innovative Properties Company | Verfahren zur herstellung von mikronadeln, mikronadelanordnung, vorlage und replikationswerkzeug |
CA2653631A1 (en) | 2006-06-07 | 2007-12-13 | Unomedical A/S | Inserter |
EP2026861A1 (de) | 2006-06-09 | 2009-02-25 | Unomedical A/S | Befestigungsauflage |
DE102006028781A1 (de) | 2006-06-23 | 2007-12-27 | Robert Bosch Gmbh | Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung |
US8865288B2 (en) | 2006-07-17 | 2014-10-21 | University Of Utah Research Foundation | Micro-needle arrays having non-planar tips and methods of manufacture thereof |
US20080138581A1 (en) * | 2006-07-17 | 2008-06-12 | Rajmohan Bhandari | Masking high-aspect aspect ratio structures |
US7951300B2 (en) * | 2006-07-17 | 2011-05-31 | University Of Utah Research Foundation | Water-scale needle array |
JP4396776B2 (ja) | 2006-07-27 | 2010-01-13 | 凸版印刷株式会社 | マイクロニードルの製造方法 |
CN101500627B (zh) | 2006-08-02 | 2012-03-14 | 优诺医疗有限公司 | 套管和输送装置 |
US20090326415A1 (en) * | 2006-08-28 | 2009-12-31 | Agency For Science ,Technology And Research | Microneedles and methods for fabricating microneedles |
US20090318833A1 (en) * | 2006-09-18 | 2009-12-24 | Agency For Science Technology And Research | Needle Structures and Methods for Fabricating Needle Structures |
EP1917990A1 (de) | 2006-10-31 | 2008-05-07 | Unomedical A/S | Infusionsset |
US7713196B2 (en) * | 2007-03-09 | 2010-05-11 | Nellcor Puritan Bennett Llc | Method for evaluating skin hydration and fluid compartmentalization |
US20090011158A1 (en) * | 2007-03-18 | 2009-01-08 | Nanopass Technologies Ltd. | Microneedle structures and corresponding production methods employing a backside wet etch |
JP2010529891A (ja) * | 2007-06-15 | 2010-09-02 | ライフスキャン・インコーポレイテッド | 可撓性カニューレ又は医療装置導管 |
DE202008017390U1 (de) | 2007-06-20 | 2009-08-13 | Unomedical A/S | Katheter und Vorrichtung zum Herstellen eines solchen Katheters |
JP2010531692A (ja) | 2007-07-03 | 2010-09-30 | ウノメディカル アクティーゼルスカブ | 双安定均衡状態を持つ挿入器 |
KR20100062991A (ko) | 2007-07-10 | 2010-06-10 | 우노메디컬 에이/에스 | 두 개의 스프링을 갖는 인서터 |
CA2694952A1 (en) | 2007-07-18 | 2009-01-22 | Unomedical A/S | Insertion device with pivoting action |
MY157968A (en) * | 2007-11-14 | 2016-08-30 | Mimos Berhad | Method for fabricating microneedled and microneedle fabricated from the same |
CN101970030B (zh) * | 2007-12-17 | 2014-04-16 | 新世界药品有限公司 | 整合的真皮内递送、诊断和通讯系统 |
EP2072076A1 (de) * | 2007-12-17 | 2009-06-24 | Debiotech S.A. | Herstellungsverfahren für Mikronadeln für den Außenbereich eines Flugzeugs |
GB0802447D0 (en) | 2008-02-09 | 2008-03-19 | Univ Manchester | Fluid extraction device, associated materials and methods |
RU2010137844A (ru) | 2008-02-13 | 2012-03-20 | Уномедикал А/С (Dk) | Уплотнение между канюльной частью и путем прохождения текучей среды |
CA2715667A1 (en) | 2008-02-20 | 2009-08-27 | Unomedical A/S | Insertion device with horizontally moving part |
US20090301994A1 (en) * | 2008-05-12 | 2009-12-10 | Rajmohan Bhandari | Methods for Wafer Scale Processing of Needle Array Devices |
WO2009149197A2 (en) | 2008-06-03 | 2009-12-10 | University Of Utah Research Foundation | High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same |
NL2001718C2 (nl) | 2008-06-24 | 2009-12-28 | Needle Holding B V U | Micronaald, micronaaldarray en fabricagewerkwijze daarvoor. |
JP2012513224A (ja) | 2008-12-22 | 2012-06-14 | ウノメディカル アクティーゼルスカブ | 接着剤パッドを含む医療デバイス |
FI20095433A0 (fi) | 2009-04-20 | 2009-04-20 | Valtion Teknillinen | Mikroneula |
EP2275164A1 (de) * | 2009-07-15 | 2011-01-19 | Debiotech S.A. | Mikronadeln mit mehreren Kanälen |
US9526885B1 (en) * | 2009-07-29 | 2016-12-27 | University Of South Florida | Microneedles with sharpened tips and corresponding method of fabrication |
BR112012002050A2 (pt) | 2009-07-30 | 2016-05-17 | Unomedical As | dispositivo insersor com parte de movimento horizontal. |
KR20120047896A (ko) | 2009-08-07 | 2012-05-14 | 우노메디컬 에이/에스 | 센서와 하나 또는 그 이상의 캐뉼라들을 가진 전달 장치 |
US20110144591A1 (en) * | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
EP2338557A1 (de) | 2009-12-23 | 2011-06-29 | Debiotech S.A. | Lösliche Mikronadel |
JP2013517889A (ja) * | 2010-01-29 | 2013-05-20 | ユーバイオメッド インク. | マイクロニードル及びマイクロニードル装置 |
BR112012024635A2 (pt) | 2010-03-30 | 2017-08-08 | Unomedical As | dispositivo médico |
MX336139B (es) | 2010-04-28 | 2016-01-08 | Kimberly Clark Co | Dispositivos medicos para la entrega de arn de interferencia corta. |
WO2012046149A1 (en) | 2010-04-28 | 2012-04-12 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
KR101790815B1 (ko) | 2010-04-28 | 2017-10-26 | 킴벌리-클라크 월드와이드, 인크. | 세포성 상호작용이 향상된 나노패턴화 의료 기구 |
US9522263B2 (en) | 2010-04-28 | 2016-12-20 | Kimberly-Clark Worldwide, Inc. | Device for delivery of rheumatoid arthritis medication |
JP5592147B2 (ja) * | 2010-04-28 | 2014-09-17 | ヤマハ株式会社 | シリコンナノニードルおよびその製造方法 |
KR101180032B1 (ko) | 2010-07-12 | 2012-09-05 | 인싸이토(주) | 외형 조절이 가능한 중공형 마이크로니들의 제조방법 |
EP2433663A1 (de) | 2010-09-27 | 2012-03-28 | Unomedical A/S | Einführsystem |
EP2436412A1 (de) | 2010-10-04 | 2012-04-04 | Unomedical A/S | Sprinklerkanüle |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
KR101651809B1 (ko) * | 2011-09-23 | 2016-08-29 | 에프. 호프만-라 로슈 아게 | 관통 요소의 마스크-에칭을 위한 방법 |
WO2013050277A1 (en) | 2011-10-05 | 2013-04-11 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
EP2583715A1 (de) | 2011-10-19 | 2013-04-24 | Unomedical A/S | Infusionsschlauchsystem und Herstellungsverfahren |
AU2012328037B2 (en) | 2011-10-27 | 2017-11-02 | Vivasor, Inc. | Transdermal delivery of high viscosity bioactive agents |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
EP2662110A1 (de) | 2012-05-10 | 2013-11-13 | Debiotech S.A. | Vorrichtung und Methode für das Einsetzen von Nadeln |
JP6269111B2 (ja) * | 2013-01-31 | 2018-01-31 | 生化学工業株式会社 | マイクロニードル及びマイクロニードルアレイ |
CN105122135B (zh) | 2013-02-12 | 2020-03-20 | 卡本有限公司 | 连续液体中间相打印 |
US10471699B2 (en) | 2014-06-20 | 2019-11-12 | Carbon, Inc. | Three-dimensional printing with reciprocal feeding of polymerizable liquid |
WO2016149152A1 (en) * | 2015-03-13 | 2016-09-22 | The University Of North Carolina At Chapel Hill | Polymeric microneedles and rapid additive manufacturing of the same |
CN107427406B (zh) | 2015-04-13 | 2020-06-09 | 贝勒斯医疗有限公司 | 胶原刺激装置和方法 |
WO2017156347A1 (en) * | 2016-03-09 | 2017-09-14 | Incube Labs, Llc | Methods and articles for delivering viable cells into solid tissue |
KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
US11241563B2 (en) | 2016-12-22 | 2022-02-08 | Johnson & Johnson Consumer Inc. | Microneedle arrays and methods for making and using |
JP6525017B2 (ja) * | 2017-01-27 | 2019-06-05 | 大日本印刷株式会社 | マイクロニードルデバイス |
EP3603731A4 (de) * | 2017-03-31 | 2020-07-15 | Toppan Printing Co., Ltd. | Vorrichtung für perkutane verabreichung |
JP6304431B2 (ja) * | 2017-06-01 | 2018-04-04 | 大日本印刷株式会社 | マイクロニードルデバイス |
EP3813809A1 (de) | 2018-06-29 | 2021-05-05 | Johnson & Johnson Consumer Inc. | Vorrichtungen für dreidimensionale mikrofluidik zur abgabe von wirkstoffen |
CN111228642A (zh) * | 2020-02-12 | 2020-06-05 | 成都工业学院 | 一种中空微针阵列装置及制作方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2535602B1 (fr) | 1982-11-05 | 1986-06-13 | Stallergenes Lab | Dispositif scarificateur |
US5312456A (en) * | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
US6219574B1 (en) * | 1996-06-18 | 2001-04-17 | Alza Corporation | Device and method for enchancing transdermal sampling |
US6610235B1 (en) | 1997-06-30 | 2003-08-26 | The Regents Of The University Of California | Method of fabricating epidermal abrasion device |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
GB9815820D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Improvements relating to micro-machining |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6406638B1 (en) * | 2000-01-06 | 2002-06-18 | The Regents Of The University Of California | Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby |
ATE296575T1 (de) * | 2000-01-21 | 2005-06-15 | Instrumentarium Corp | Herstellungsverfahren für eine medizinische elektrode |
US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
DE10065168A1 (de) | 2000-12-23 | 2002-07-11 | Lohmann Therapie Syst Lts | Nadelpflaster mit vermindertem Infektionsrisiko |
US6767341B2 (en) * | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
US6962772B2 (en) * | 2002-12-27 | 2005-11-08 | Industrial Technology Research Inst. | Method for manufacturing 3-D high aspect-ratio microneedle array device |
US7132054B1 (en) * | 2004-09-08 | 2006-11-07 | Sandia Corporation | Method to fabricate hollow microneedle arrays |
-
2001
- 2001-08-14 SE SE0102736A patent/SE0102736D0/xx unknown
-
2002
- 2002-08-14 CA CA002457677A patent/CA2457677C/en not_active Expired - Lifetime
- 2002-08-14 AU AU2002326256A patent/AU2002326256B2/en not_active Ceased
- 2002-08-14 US US10/486,541 patent/US7258805B2/en not_active Expired - Fee Related
- 2002-08-14 AT AT02760947T patent/ATE342748T1/de not_active IP Right Cessation
- 2002-08-14 JP JP2003520813A patent/JP4348181B2/ja not_active Expired - Fee Related
- 2002-08-14 DE DE60215516T patent/DE60215516T2/de not_active Expired - Lifetime
- 2002-08-14 WO PCT/SE2002/001456 patent/WO2003015860A1/en active IP Right Grant
- 2002-08-14 EP EP02760947A patent/EP1416996B1/de not_active Expired - Lifetime
-
2007
- 2007-07-19 US US11/826,871 patent/US7901387B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60215516T2 (de) | 2007-08-30 |
EP1416996A1 (de) | 2004-05-12 |
US7901387B2 (en) | 2011-03-08 |
CA2457677C (en) | 2009-10-06 |
US20040267205A1 (en) | 2004-12-30 |
US20080039806A1 (en) | 2008-02-14 |
JP2004538106A (ja) | 2004-12-24 |
CA2457677A1 (en) | 2003-02-27 |
SE0102736D0 (sv) | 2001-08-14 |
EP1416996B1 (de) | 2006-10-18 |
DE60215516D1 (de) | 2006-11-30 |
US7258805B2 (en) | 2007-08-21 |
JP4348181B2 (ja) | 2009-10-21 |
AU2002326256B2 (en) | 2008-05-22 |
WO2003015860A1 (en) | 2003-02-27 |
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