ATE340853T1 - Gene der il-12p40 untereinheit, welche zur verbesserung der aktivität mutiert sind, und deren verwendung als adjuvans zur dna vakzinierung - Google Patents
Gene der il-12p40 untereinheit, welche zur verbesserung der aktivität mutiert sind, und deren verwendung als adjuvans zur dna vakzinierungInfo
- Publication number
- ATE340853T1 ATE340853T1 AT01914236T AT01914236T ATE340853T1 AT E340853 T1 ATE340853 T1 AT E340853T1 AT 01914236 T AT01914236 T AT 01914236T AT 01914236 T AT01914236 T AT 01914236T AT E340853 T1 ATE340853 T1 AT E340853T1
- Authority
- AT
- Austria
- Prior art keywords
- mutant gene
- dna vaccination
- subunity
- adjuvants
- asn
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 238000011238 DNA vaccination Methods 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000002671 adjuvant Substances 0.000 title 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 abstract 5
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 abstract 5
- 102000013462 Interleukin-12 Human genes 0.000 abstract 3
- 108010065805 Interleukin-12 Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 108010041986 DNA Vaccines Proteins 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000024932 T cell mediated immunity Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
- 239000012646 vaccine adjuvant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20000013133 | 2000-03-15 | ||
| KR10-2001-0012987A KR100399728B1 (ko) | 2000-03-15 | 2001-03-13 | ＩＬ-12 활성을 증가시키는 ＩＬ-12ｐ40 소단위체돌연변이 유전자 및 이를 ＤＮＡ 백신 면역증강제로이용하는 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340853T1 true ATE340853T1 (de) | 2006-10-15 |
Family
ID=36763001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01914236T ATE340853T1 (de) | 2000-03-15 | 2001-03-15 | Gene der il-12p40 untereinheit, welche zur verbesserung der aktivität mutiert sind, und deren verwendung als adjuvans zur dna vakzinierung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7253151B2 (de) |
| EP (1) | EP1268759B1 (de) |
| JP (1) | JP4180826B2 (de) |
| CN (1) | CN1281748C (de) |
| AT (1) | ATE340853T1 (de) |
| AU (2) | AU2001239581B2 (de) |
| CA (1) | CA2402213C (de) |
| DE (1) | DE60123400T2 (de) |
| ES (1) | ES2272448T3 (de) |
| WO (1) | WO2001068802A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100788930B1 (ko) * | 2006-04-18 | 2007-12-27 | 포항공과대학교 산학협력단 | 항암 조성물 |
| WO2007137328A1 (en) * | 2006-05-26 | 2007-12-06 | Apollo Life Sciences Limited | An isolated il-12 molecule or chimeric molecules thereof |
| CN101935687B (zh) * | 2009-06-29 | 2012-11-07 | 中国科学院上海生命科学研究院 | 用IL-12p40 siRNA促进肝再生 |
| WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
| CA2962099A1 (en) * | 2014-09-22 | 2016-03-31 | Intrexon Corporation | Improved therapeutic control of heterodimeric and single chain forms of interleukin-12 |
| IL299646A (en) * | 2015-12-18 | 2023-03-01 | Oncosec Medical Inc | Plasmid templates for heterologous protein expression and methods of use |
| LT3458083T (lt) | 2016-05-18 | 2023-02-10 | Modernatx, Inc. | Polinukleotidai, koduojantys interleukiną-12 (il12), ir jų naudojimas |
| CA3063723A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
| CR20200303A (es) | 2017-12-12 | 2020-12-23 | Pionyr Immunotherapeutics Inc | Anticuerpos anti-trem2 y métodos relacionados |
| WO2019151759A1 (ko) * | 2018-02-02 | 2019-08-08 | 주식회사 에스엘백시젠 | 신규 백신 면역보조제 |
| KR20210069641A (ko) | 2018-10-03 | 2021-06-11 | 젠코어 인코포레이티드 | IL-12 이종이량체 Fc-융합 단백질 |
| CN109517052A (zh) * | 2018-12-04 | 2019-03-26 | 江苏禄亿生生物科技有限公司 | 一种il-12蛋白突变体及其制备方法和应用、nk细胞培养体系和培养nk细胞的方法 |
| EP4037700A2 (de) | 2019-10-03 | 2022-08-10 | Xencor, Inc. | Zielgerichtete il-12-heterodimere fc-fusionsproteine |
| US20240041939A1 (en) * | 2021-12-17 | 2024-02-08 | William Marsh Rice University | Encapsulated cells expressing il-12 and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013268A (en) * | 1994-04-22 | 2000-01-11 | Corixa Corporation | Methods for enhancement of protective immune responses |
| EP0818534A1 (de) * | 1996-07-12 | 1998-01-14 | Janssen Pharmaceutica N.V. | Menschliche Interleukine-12 Genexpressions-regulierende Sequenzen |
| US6517839B1 (en) * | 1997-07-18 | 2003-02-11 | The Regents Of The University Of California | Methods for inducing interleukin-12 and a type1/Th1 T-cell response |
-
2001
- 2001-03-15 ES ES01914236T patent/ES2272448T3/es not_active Expired - Lifetime
- 2001-03-15 WO PCT/KR2001/000408 patent/WO2001068802A2/en active IP Right Grant
- 2001-03-15 CN CNB018084990A patent/CN1281748C/zh not_active Expired - Fee Related
- 2001-03-15 US US10/221,975 patent/US7253151B2/en not_active Expired - Fee Related
- 2001-03-15 AU AU2001239581A patent/AU2001239581B2/en not_active Ceased
- 2001-03-15 JP JP2001567286A patent/JP4180826B2/ja not_active Expired - Fee Related
- 2001-03-15 DE DE60123400T patent/DE60123400T2/de not_active Expired - Lifetime
- 2001-03-15 AT AT01914236T patent/ATE340853T1/de not_active IP Right Cessation
- 2001-03-15 AU AU3958101A patent/AU3958101A/xx active Pending
- 2001-03-15 EP EP01914236A patent/EP1268759B1/de not_active Expired - Lifetime
- 2001-03-15 CA CA2402213A patent/CA2402213C/en not_active Expired - Fee Related
-
2007
- 2007-08-02 US US11/832,993 patent/US7910564B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1281748C (zh) | 2006-10-25 |
| DE60123400T2 (de) | 2007-08-23 |
| CA2402213C (en) | 2012-08-07 |
| DE60123400D1 (de) | 2006-11-09 |
| US7253151B2 (en) | 2007-08-07 |
| CA2402213A1 (en) | 2001-09-20 |
| WO2001068802A3 (en) | 2002-02-21 |
| EP1268759A2 (de) | 2003-01-02 |
| CN1426464A (zh) | 2003-06-25 |
| JP4180826B2 (ja) | 2008-11-12 |
| JP2003526360A (ja) | 2003-09-09 |
| EP1268759A4 (de) | 2005-09-28 |
| AU3958101A (en) | 2001-09-24 |
| AU2001239581B2 (en) | 2006-01-05 |
| US20070269408A1 (en) | 2007-11-22 |
| US7910564B2 (en) | 2011-03-22 |
| ES2272448T3 (es) | 2007-05-01 |
| WO2001068802A2 (en) | 2001-09-20 |
| US20040023332A1 (en) | 2004-02-05 |
| EP1268759B1 (de) | 2006-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |