ATE414761T1 - Verringerung der virulenz von mycobacterium tuberculosis und tuberkuloseschutz mittels inaktivierung des phop-gens - Google Patents

Verringerung der virulenz von mycobacterium tuberculosis und tuberkuloseschutz mittels inaktivierung des phop-gens

Info

Publication number
ATE414761T1
ATE414761T1 AT02751195T AT02751195T ATE414761T1 AT E414761 T1 ATE414761 T1 AT E414761T1 AT 02751195 T AT02751195 T AT 02751195T AT 02751195 T AT02751195 T AT 02751195T AT E414761 T1 ATE414761 T1 AT E414761T1
Authority
AT
Austria
Prior art keywords
phop
tuberculosis
virulence
mutant
inactivation
Prior art date
Application number
AT02751195T
Other languages
English (en)
Inventor
Montanes Carlos Martin
Brigitte Gicquel
Herran Ester Perez
Original Assignee
Univ Zaragoza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zaragoza filed Critical Univ Zaragoza
Application granted granted Critical
Publication of ATE414761T1 publication Critical patent/ATE414761T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT02751195T 2001-07-31 2002-07-30 Verringerung der virulenz von mycobacterium tuberculosis und tuberkuloseschutz mittels inaktivierung des phop-gens ATE414761T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101824A ES2192949B1 (es) 2001-07-31 2001-07-31 Disminucion de la virulencia de mycobacterium tuberculosis por la inactivacion del gen phop.

Publications (1)

Publication Number Publication Date
ATE414761T1 true ATE414761T1 (de) 2008-12-15

Family

ID=8498623

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02751195T ATE414761T1 (de) 2001-07-31 2002-07-30 Verringerung der virulenz von mycobacterium tuberculosis und tuberkuloseschutz mittels inaktivierung des phop-gens

Country Status (9)

Country Link
US (1) US7468190B2 (de)
EP (1) EP1428870B1 (de)
JP (1) JP4153423B2 (de)
AT (1) ATE414761T1 (de)
CA (1) CA2456007C (de)
DE (1) DE60229962D1 (de)
ES (2) ES2192949B1 (de)
PT (1) PT1428870E (de)
WO (1) WO2003012075A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1997881B1 (de) 2006-03-24 2013-09-25 Universidad de Zaragoza Tuberkulose-impfstoff
US20100317084A1 (en) * 2007-05-10 2010-12-16 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens
WO2009025888A2 (en) 2007-05-10 2009-02-26 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety
WO2009046451A1 (en) * 2007-10-05 2009-04-09 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting a protective immune response against c. perfringens
WO2010045620A1 (en) 2008-10-17 2010-04-22 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae
US9163219B2 (en) * 2009-04-14 2015-10-20 Arizona Board Of Regents On Behalf Of Arizona State University Single expression vector for generation of a virus with a segmented genome
GB2483595B (en) 2009-05-22 2017-03-29 The Arizona Board Of Regents For And On Behalf Of Arizona State Univ Recombinant bacterium and methods of antigen and nucleic acid delivery
US9045742B2 (en) * 2009-05-29 2015-06-02 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant Edwardsiella bacterium
US9062297B2 (en) 2010-01-13 2015-06-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Yersinia pestis vaccine
US8889121B2 (en) 2010-01-22 2014-11-18 The Arizona Board Of Regents For An On Behalf Of Arizona State University Bacterium comprising a regulated rfaH nucleic acid
WO2011130878A1 (en) * 2010-04-22 2011-10-27 Shenzhen Christyins Biosciences Ltd. Tuberculosis vaccines including recombinant bcg strains overexpressing phop, and/or phop regulon protein(s)
US9598697B2 (en) 2010-05-28 2017-03-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
US9303264B2 (en) 2012-05-18 2016-04-05 The Arizona Board Of Regents For And On Behalf Of Arizona State University Photosynthetic microorganisms expressing thermostable lipase
US9580718B2 (en) 2013-06-17 2017-02-28 Arizona Board Of Regents On Behalf Of Arizona State University Attenuated live bacteria with increased acid resistance and methods of use thereof
CN109423479A (zh) * 2017-09-05 2019-03-05 江苏齐氏生物科技有限公司 一种大鼠骨髓巨噬细胞分离及培养方法
CN109810932A (zh) * 2019-02-09 2019-05-28 济宁医学院 新疆地区的结核分枝杆菌临床分离株中存在PhoP基因的天然缺失突变菌株

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0465560T3 (da) * 1989-03-31 1996-10-28 Univ Washington Vacciner indeholdende avirulente mikroorganismer af phoP-type
US5843426A (en) * 1990-12-18 1998-12-01 The General Hospital Corporation Salmonella vaccines
US5695983A (en) 1990-12-18 1997-12-09 The General Hospital Corporation Salmonella vaccines

Also Published As

Publication number Publication date
DE60229962D1 (de) 2009-01-02
EP1428870B1 (de) 2008-11-19
ES2192949A1 (es) 2003-10-16
PT1428870E (pt) 2009-02-16
WO2003012075A1 (es) 2003-02-13
EP1428870A1 (de) 2004-06-16
US7468190B2 (en) 2008-12-23
JP2004535827A (ja) 2004-12-02
JP4153423B2 (ja) 2008-09-24
US20050106175A1 (en) 2005-05-19
CA2456007C (en) 2013-10-08
ES2316590T3 (es) 2009-04-16
CA2456007A1 (en) 2003-02-13
ES2192949B1 (es) 2004-08-16

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