ATE329926T1 - Verfahren und zusammensetzungen für die behandlung von neoplastichen krankheiten - Google Patents
Verfahren und zusammensetzungen für die behandlung von neoplastichen krankheitenInfo
- Publication number
- ATE329926T1 ATE329926T1 AT97942549T AT97942549T ATE329926T1 AT E329926 T1 ATE329926 T1 AT E329926T1 AT 97942549 T AT97942549 T AT 97942549T AT 97942549 T AT97942549 T AT 97942549T AT E329926 T1 ATE329926 T1 AT E329926T1
- Authority
- AT
- Austria
- Prior art keywords
- fragments
- plasminogen
- provides
- methods
- plasminogen activator
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 201000010099 disease Diseases 0.000 title abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001613 neoplastic effect Effects 0.000 title 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 6
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 5
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 5
- 229940127126 plasminogen activator Drugs 0.000 abstract 5
- 230000002491 angiogenic effect Effects 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 108010088842 Fibrinolysin Proteins 0.000 abstract 3
- 102000013566 Plasminogen Human genes 0.000 abstract 3
- 108010051456 Plasminogen Proteins 0.000 abstract 3
- 229940012957 plasmin Drugs 0.000 abstract 3
- 102000012936 Angiostatins Human genes 0.000 abstract 2
- 108010079709 Angiostatins Proteins 0.000 abstract 2
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 abstract 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/710,305 US5801012A (en) | 1996-09-17 | 1996-09-17 | Methods and compositions for generating angiostatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE329926T1 true ATE329926T1 (de) | 2006-07-15 |
Family
ID=24853480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97942549T ATE329926T1 (de) | 1996-09-17 | 1997-09-17 | Verfahren und zusammensetzungen für die behandlung von neoplastichen krankheiten |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5801012A (https=) |
| EP (2) | EP0964869B1 (https=) |
| JP (1) | JP4160121B2 (https=) |
| AT (1) | ATE329926T1 (https=) |
| AU (1) | AU4422797A (https=) |
| CA (1) | CA2265550A1 (https=) |
| DE (1) | DE69736129T2 (https=) |
| ES (1) | ES2267151T3 (https=) |
| WO (1) | WO1998015574A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945403A (en) * | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| US7297331B2 (en) * | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
| EP1001985A1 (en) * | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
| AU1731300A (en) * | 1998-11-25 | 2000-06-13 | Bristol-Myers Squibb Company | Compositions comprising angiostatin and kringle 5 region of plasminogen and methods of use thereof |
| WO2001019868A1 (en) | 1999-09-15 | 2001-03-22 | Mogam Biotechnology Research Institute | A novel angiogenesis inhibitor |
| WO2001058921A2 (en) * | 2000-02-08 | 2001-08-16 | Northwestern University | Methods and compositions for generating angiostatin |
| CA2421251A1 (en) | 2000-09-05 | 2002-03-14 | Karolinska Innovations Ab | Recombinant endothelial cell growth inhibitors derived from a mammalian plasminogen |
| CA2426543C (en) | 2000-11-28 | 2007-09-18 | David M. Waisman | Anti-angiogenic polypeptides |
| ITMI20011995A1 (it) * | 2001-09-26 | 2003-03-26 | Ist Naz Ricerca Sul Cancro | Sostanze ad attivita' antinfiammatoria |
| US7285277B2 (en) * | 2002-03-15 | 2007-10-23 | Mogam Biotechnology Research Institute | Anticancer agent |
| WO2004005248A1 (en) * | 2002-07-02 | 2004-01-15 | Novartis Ag | Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap) |
| AU2003297181A1 (en) * | 2002-12-13 | 2004-07-09 | Mediomics, Llc | Compositions and methods for inhibiting tumor growth and metastasis |
| US7776005B2 (en) * | 2003-03-28 | 2010-08-17 | Covidien Ag | Triple lumen catheter with occlusion resistant tip |
| US7141035B2 (en) * | 2003-03-28 | 2006-11-28 | Sherwood Services Ag | Catheter with occlusion resistant tip |
| US7090654B2 (en) * | 2003-03-28 | 2006-08-15 | Sherwood Services Ag | Catheter with occlusion resistant tip |
| US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| CN1889929B (zh) * | 2003-11-14 | 2013-04-10 | 阿尔萨公司 | 药物递送媒介物中的赋形剂 |
| WO2006055288A2 (en) | 2004-11-04 | 2006-05-26 | Sherwood Service Ag | Catheter insertion apparatus |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| WO2009100617A1 (zh) * | 2008-02-04 | 2009-08-20 | Shanghai First People's Hospital | 抑制血管新生的多肽及其应用 |
| CN102458508B (zh) | 2009-06-26 | 2014-06-25 | 泰科保健集团有限合伙公司 | 导管插入系统 |
| CA2715857A1 (en) | 2009-09-30 | 2011-03-30 | Tyco Healthcare Group Lp | Medical catheter having a design providing low recirculation and reversibility |
| US8747343B2 (en) | 2011-09-30 | 2014-06-10 | Covidien Lp | Hemodialysis catheter with improved side opening design |
| US9072867B2 (en) | 2011-09-30 | 2015-07-07 | Covidien Lp | Catheter with external flow channel |
| US9216163B2 (en) | 2013-05-20 | 2015-12-22 | Kyorin Pharmaceutical Co., Ltd. | Method of inhibiting angiogenesis |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2431342C3 (de) * | 1973-07-27 | 1978-10-26 | Behringwerke Ag, 3550 Marburg | Verfahren zur Messung des Plasminogengehaltes durch Bestimmung der Bildung von Fibrin in einer Probe |
| US4968494A (en) * | 1987-03-27 | 1990-11-06 | Merck & Co., Inc. | Methods and compositions for thrombolytic therapy |
| US5135919A (en) | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US5021404A (en) | 1988-04-20 | 1991-06-04 | The Children's Medical Center Corporation | Angiostatic collagen modulators |
| KR0138530B1 (ko) | 1988-09-01 | 1998-05-15 | 우메모또 요시마사 | 푸마길롤 유도체 |
| PT93847A (pt) | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US5192744A (en) | 1990-01-12 | 1993-03-09 | Northwestern University | Method of inhibiting angiogenesis of tumors |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| AU709633B2 (en) | 1995-04-26 | 1999-09-02 | Children's Medical Center Corporation | Angiostatin fragments and aggregate angiostatin and methods of use |
| US5837682A (en) | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| HUT76095A (en) | 1994-04-26 | 1997-06-30 | Childrens Medical Center | Angiostatin and method of use for inhibition of angiogenesis |
| US5945403A (en) | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| US5861372A (en) | 1996-02-22 | 1999-01-19 | The Children's Medical Center Corporation | Aggregate angiostatin and method of use |
| WO1996041194A1 (en) | 1995-06-07 | 1996-12-19 | The Children's Medical Center Corporation | Diagnosis, prognosis and monitoring of angiogenesis dependent diseases |
| DE19529223A1 (de) * | 1995-08-09 | 1997-02-13 | Boehringer Mannheim Gmbh | Verwendung von Plasminogenaktivatoren zum lokalen Knochenaufbau |
| CN1202932A (zh) | 1995-10-23 | 1998-12-23 | 儿童医学中心公司 | 治疗用抗血管生成的组合物和方法 |
| US5854221A (en) | 1996-12-12 | 1998-12-29 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and method of use |
| EP0869970B1 (en) | 1995-12-13 | 2004-03-24 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and its use |
| WO1997041824A2 (en) | 1996-05-03 | 1997-11-13 | Abbott Laboratories | Antiangiogenic peptides derived from plasminogen |
| EP1001985A1 (en) | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
-
1996
- 1996-09-17 US US08/710,305 patent/US5801012A/en not_active Expired - Fee Related
-
1997
- 1997-09-17 ES ES97942549T patent/ES2267151T3/es not_active Expired - Lifetime
- 1997-09-17 WO PCT/US1997/016539 patent/WO1998015574A1/en not_active Ceased
- 1997-09-17 AT AT97942549T patent/ATE329926T1/de not_active IP Right Cessation
- 1997-09-17 JP JP51753898A patent/JP4160121B2/ja not_active Expired - Fee Related
- 1997-09-17 CA CA002265550A patent/CA2265550A1/en not_active Abandoned
- 1997-09-17 EP EP97942549A patent/EP0964869B1/en not_active Expired - Lifetime
- 1997-09-17 DE DE69736129T patent/DE69736129T2/de not_active Expired - Fee Related
- 1997-09-17 EP EP06112574A patent/EP1705184A1/en not_active Withdrawn
- 1997-09-18 AU AU44227/97A patent/AU4422797A/en not_active Abandoned
- 1997-12-16 US US08/991,761 patent/US6576609B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2267151T3 (es) | 2007-03-01 |
| EP0964869A1 (en) | 1999-12-22 |
| AU4422797A (en) | 1998-05-05 |
| EP0964869B1 (en) | 2006-06-14 |
| CA2265550A1 (en) | 1998-04-16 |
| JP2001502534A (ja) | 2001-02-27 |
| US6576609B1 (en) | 2003-06-10 |
| JP4160121B2 (ja) | 2008-10-01 |
| EP1705184A1 (en) | 2006-09-27 |
| DE69736129D1 (de) | 2006-07-27 |
| DE69736129T2 (de) | 2007-01-04 |
| EP0964869A4 (en) | 2003-06-04 |
| US5801012A (en) | 1998-09-01 |
| WO1998015574A1 (en) | 1998-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0964869 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |