DK0953576T3 - Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse - Google Patents

Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse

Info

Publication number
DK0953576T3
DK0953576T3 DK99108032T DK99108032T DK0953576T3 DK 0953576 T3 DK0953576 T3 DK 0953576T3 DK 99108032 T DK99108032 T DK 99108032T DK 99108032 T DK99108032 T DK 99108032T DK 0953576 T3 DK0953576 T3 DK 0953576T3
Authority
DK
Denmark
Prior art keywords
hedgehog protein
preparation
hydrophobic
protein conjugate
amino acids
Prior art date
Application number
DK99108032T
Other languages
English (en)
Inventor
Angelika Esswein
Kurt Lang
Petra Rueger
Tilmann Seytter
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/de
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DK0953576T3 publication Critical patent/DK0953576T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99108032T 1998-04-30 1999-04-23 Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse DK0953576T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107911A EP0953575A1 (de) 1998-04-30 1998-04-30 Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
EP98116733 1998-09-03

Publications (1)

Publication Number Publication Date
DK0953576T3 true DK0953576T3 (da) 2006-03-20

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99108032T DK0953576T3 (da) 1998-04-30 1999-04-23 Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse

Country Status (18)

Country Link
US (4) US6468978B1 (da)
EP (2) EP0953576B1 (da)
JP (1) JP3433136B2 (da)
KR (1) KR19990083621A (da)
CN (1) CN1233616A (da)
AT (1) ATE308563T1 (da)
AU (1) AU719797B2 (da)
CA (1) CA2269221A1 (da)
CY (1) CY1105683T1 (da)
DE (1) DE69928040T2 (da)
DK (1) DK0953576T3 (da)
ES (1) ES2252886T3 (da)
HU (1) HUP9901411A2 (da)
IL (1) IL129620A (da)
MA (1) MA26625A1 (da)
NO (1) NO992090L (da)
NZ (1) NZ335385A (da)
SG (1) SG80028A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP0953576B1 (en) * 1998-04-30 2005-11-02 Curis, Inc. Active hedgehog protein conjugate, process for its production and use
EP0978285B1 (en) * 1998-08-07 2005-11-23 F. Hoffmann-La Roche Ag Stable pharmaceutical composition of hedgehog proteins and use thereof.
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
AU763032B2 (en) * 1998-12-03 2003-07-10 Curis, Inc. Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
WO2000073337A1 (en) * 1999-06-01 2000-12-07 Biogen, Inc. Polymer conjugates of hedgehog proteins and uses
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
WO2010065908A2 (en) * 2008-12-05 2010-06-10 Catchmark Jeffrey M Degradable biomolecule compositions
US20110086236A1 (en) * 2009-10-13 2011-04-14 The Penn State Research Foundation Composites containing polypeptides attached to polysaccharides and molecules
RU2637085C2 (ru) * 2011-06-06 2017-11-29 КИНЕТА УАН, ЭлЭлСи Фармацевтические композиции на основе shk и способы их получения и использования
US10202517B2 (en) 2013-07-26 2019-02-12 The Penn State Research Foundation Polymer compositions and coatings
KR20170065016A (ko) * 2015-12-02 2017-06-12 한미약품 주식회사 지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
CA2071912C (en) * 1990-11-30 2002-10-15 Hanne Bentz Use of a bone morphogenetic protein in synergistic combination with tgf-beta for bone repair
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
CA2179029C (en) * 1993-12-30 2009-02-24 Philip W. Ingham Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
CA2267106A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
AU757497B2 (en) * 1997-12-03 2003-02-20 Biogen, Inc. Hydrophobically-modified protein compositions and methods
EP0953576B1 (en) * 1998-04-30 2005-11-02 Curis, Inc. Active hedgehog protein conjugate, process for its production and use
EP0978285B1 (en) * 1998-08-07 2005-11-23 F. Hoffmann-La Roche Ag Stable pharmaceutical composition of hedgehog proteins and use thereof.
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro

Also Published As

Publication number Publication date
CA2269221A1 (en) 1999-10-30
AU719797B2 (en) 2000-05-18
JP3433136B2 (ja) 2003-08-04
US7153836B2 (en) 2006-12-26
EP0953576B1 (en) 2005-11-02
US20050148510A1 (en) 2005-07-07
EP1557427A2 (en) 2005-07-27
EP1557427A3 (en) 2005-10-19
CN1233616A (zh) 1999-11-03
JP2000053699A (ja) 2000-02-22
SG80028A1 (en) 2001-04-17
HUP9901411A2 (hu) 1999-12-28
NZ335385A (en) 2000-09-29
NO992090D0 (no) 1999-04-29
US20070191274A1 (en) 2007-08-16
NO992090L (no) 1999-11-01
HU9901411D0 (en) 1999-07-28
KR19990083621A (ko) 1999-11-25
ATE308563T1 (de) 2005-11-15
EP0953576A1 (en) 1999-11-03
US6468978B1 (en) 2002-10-22
MA26625A1 (fr) 2004-12-20
US6818623B2 (en) 2004-11-16
DE69928040D1 (de) 2005-12-08
ES2252886T3 (es) 2006-05-16
DE69928040T2 (de) 2006-07-27
IL129620A0 (en) 2000-02-29
AU2500999A (en) 1999-11-11
US20030139574A1 (en) 2003-07-24
CY1105683T1 (el) 2010-12-22
IL129620A (en) 2009-06-15

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