NO992090L - Aktivt proteinkonjugat fra pinnsvin samt fremgangsmåte for fremstilling og anvendelse derav - Google Patents
Aktivt proteinkonjugat fra pinnsvin samt fremgangsmåte for fremstilling og anvendelse deravInfo
- Publication number
- NO992090L NO992090L NO992090A NO992090A NO992090L NO 992090 L NO992090 L NO 992090L NO 992090 A NO992090 A NO 992090A NO 992090 A NO992090 A NO 992090A NO 992090 L NO992090 L NO 992090L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- hydrophobic
- protein conjugate
- amino acids
- porcine protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 241001481760 Erethizon dorsatum Species 0.000 abstract 1
- 102000003693 Hedgehog Proteins Human genes 0.000 abstract 1
- 108090000031 Hedgehog Proteins Proteins 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229920006395 saturated elastomer Chemical group 0.000 abstract 1
- 229930195734 saturated hydrocarbon Chemical group 0.000 abstract 1
- -1 thio compound Chemical class 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Et pinnsvinkonjugat som er karakterisert ved at det inneholder: a) et poly- peptid som består av 10-30 hydrofobe aminosyrer og/eller aminosyrer som danner transmembran-helikser og er positivt ladet, b) 1-4 alifatiske, mettede eller umette- de hydrokarbonrester med en kjedelengde på 10-24 C-atomer og med hydrofob virkning, eller c) en hydrofob tioforbindelse kovalent bundet til et pinnsvinprotein og som har en mangedoblet øket aktivitet og er egnet som farmasøytisk middel, er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98107911A EP0953575A1 (de) | 1998-04-30 | 1998-04-30 | Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung |
EP98116733 | 1998-09-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO992090D0 NO992090D0 (no) | 1999-04-29 |
NO992090L true NO992090L (no) | 1999-11-01 |
Family
ID=26149214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO992090A NO992090L (no) | 1998-04-30 | 1999-04-29 | Aktivt proteinkonjugat fra pinnsvin samt fremgangsmåte for fremstilling og anvendelse derav |
Country Status (18)
Country | Link |
---|---|
US (4) | US6468978B1 (no) |
EP (2) | EP0953576B1 (no) |
JP (1) | JP3433136B2 (no) |
KR (1) | KR19990083621A (no) |
CN (1) | CN1233616A (no) |
AT (1) | ATE308563T1 (no) |
AU (1) | AU719797B2 (no) |
CA (1) | CA2269221A1 (no) |
CY (1) | CY1105683T1 (no) |
DE (1) | DE69928040T2 (no) |
DK (1) | DK0953576T3 (no) |
ES (1) | ES2252886T3 (no) |
HU (1) | HUP9901411A2 (no) |
IL (1) | IL129620A (no) |
MA (1) | MA26625A1 (no) |
NO (1) | NO992090L (no) |
NZ (1) | NZ335385A (no) |
SG (1) | SG80028A1 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136230A0 (en) * | 1997-11-28 | 2001-05-20 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
EP0953576B1 (en) * | 1998-04-30 | 2005-11-02 | Curis, Inc. | Active hedgehog protein conjugate, process for its production and use |
EP0978285B1 (en) * | 1998-08-07 | 2005-11-23 | F. Hoffmann-La Roche Ag | Stable pharmaceutical composition of hedgehog proteins and use thereof. |
TW570805B (en) * | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
AU763032B2 (en) * | 1998-12-03 | 2003-07-10 | Curis, Inc. | Methods and compositions for treating disorders involving excitotoxicity |
EP1025861A1 (de) * | 1999-02-04 | 2000-08-09 | Roche Diagnostics GmbH | Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung |
WO2000073337A1 (en) * | 1999-06-01 | 2000-12-07 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
AU2001255767A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
US7573637B2 (en) * | 2004-08-03 | 2009-08-11 | Seiko Epson Corporation | Intrinsic polarizer and method of manufacturing an intrinsic polarizer |
US8669418B2 (en) * | 2005-12-22 | 2014-03-11 | Vib Vzw | Means and methods for mediating protein interference |
US20100316566A1 (en) * | 2008-02-27 | 2010-12-16 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
WO2010065908A2 (en) * | 2008-12-05 | 2010-06-10 | Catchmark Jeffrey M | Degradable biomolecule compositions |
US20110086236A1 (en) * | 2009-10-13 | 2011-04-14 | The Penn State Research Foundation | Composites containing polypeptides attached to polysaccharides and molecules |
RU2637085C2 (ru) * | 2011-06-06 | 2017-11-29 | КИНЕТА УАН, ЭлЭлСи | Фармацевтические композиции на основе shk и способы их получения и использования |
US10202517B2 (en) | 2013-07-26 | 2019-02-12 | The Penn State Research Foundation | Polymer compositions and coatings |
KR20170065016A (ko) * | 2015-12-02 | 2017-06-12 | 한미약품 주식회사 | 지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364839A (en) * | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
CA2071912C (en) * | 1990-11-30 | 2002-10-15 | Hanne Bentz | Use of a bone morphogenetic protein in synergistic combination with tgf-beta for bone repair |
US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
CA2179029C (en) * | 1993-12-30 | 2009-02-24 | Philip W. Ingham | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
GB9614871D0 (en) | 1996-07-15 | 1996-09-04 | Smithkline Beecham Plc | Compounds |
CA2267106A1 (en) * | 1996-10-07 | 1998-07-16 | The Johns Hopkins University School Of Medicine | Novel hedgehog-derived polypeptides |
IL136230A0 (en) * | 1997-11-28 | 2001-05-20 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
AU757497B2 (en) * | 1997-12-03 | 2003-02-20 | Biogen, Inc. | Hydrophobically-modified protein compositions and methods |
EP0953576B1 (en) * | 1998-04-30 | 2005-11-02 | Curis, Inc. | Active hedgehog protein conjugate, process for its production and use |
EP0978285B1 (en) * | 1998-08-07 | 2005-11-23 | F. Hoffmann-La Roche Ag | Stable pharmaceutical composition of hedgehog proteins and use thereof. |
AU2001255767A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
-
1999
- 1999-04-23 EP EP99108032A patent/EP0953576B1/en not_active Expired - Lifetime
- 1999-04-23 DE DE69928040T patent/DE69928040T2/de not_active Expired - Fee Related
- 1999-04-23 AT AT99108032T patent/ATE308563T1/de not_active IP Right Cessation
- 1999-04-23 DK DK99108032T patent/DK0953576T3/da active
- 1999-04-23 ES ES99108032T patent/ES2252886T3/es not_active Expired - Lifetime
- 1999-04-23 EP EP05009341A patent/EP1557427A3/en not_active Withdrawn
- 1999-04-26 NZ NZ335385A patent/NZ335385A/xx unknown
- 1999-04-27 IL IL129620A patent/IL129620A/en not_active IP Right Cessation
- 1999-04-28 US US09/301,199 patent/US6468978B1/en not_active Expired - Fee Related
- 1999-04-28 HU HU9901411A patent/HUP9901411A2/hu unknown
- 1999-04-28 SG SG9902117A patent/SG80028A1/en unknown
- 1999-04-29 MA MA25560A patent/MA26625A1/fr unknown
- 1999-04-29 CA CA002269221A patent/CA2269221A1/en not_active Abandoned
- 1999-04-29 NO NO992090A patent/NO992090L/no not_active Application Discontinuation
- 1999-04-29 KR KR1019990015503A patent/KR19990083621A/ko active IP Right Grant
- 1999-04-29 AU AU25009/99A patent/AU719797B2/en not_active Ceased
- 1999-04-29 CN CN99106302A patent/CN1233616A/zh active Pending
- 1999-04-30 JP JP12500599A patent/JP3433136B2/ja not_active Expired - Fee Related
-
2002
- 2002-10-21 US US10/278,060 patent/US6818623B2/en not_active Expired - Fee Related
-
2004
- 2004-10-08 US US10/961,982 patent/US7153836B2/en not_active Expired - Fee Related
-
2006
- 2006-02-01 CY CY20061100133T patent/CY1105683T1/el unknown
- 2006-12-22 US US11/645,014 patent/US20070191274A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2269221A1 (en) | 1999-10-30 |
AU719797B2 (en) | 2000-05-18 |
JP3433136B2 (ja) | 2003-08-04 |
US7153836B2 (en) | 2006-12-26 |
EP0953576B1 (en) | 2005-11-02 |
US20050148510A1 (en) | 2005-07-07 |
EP1557427A2 (en) | 2005-07-27 |
EP1557427A3 (en) | 2005-10-19 |
CN1233616A (zh) | 1999-11-03 |
JP2000053699A (ja) | 2000-02-22 |
SG80028A1 (en) | 2001-04-17 |
HUP9901411A2 (hu) | 1999-12-28 |
NZ335385A (en) | 2000-09-29 |
NO992090D0 (no) | 1999-04-29 |
US20070191274A1 (en) | 2007-08-16 |
HU9901411D0 (en) | 1999-07-28 |
KR19990083621A (ko) | 1999-11-25 |
ATE308563T1 (de) | 2005-11-15 |
EP0953576A1 (en) | 1999-11-03 |
US6468978B1 (en) | 2002-10-22 |
MA26625A1 (fr) | 2004-12-20 |
US6818623B2 (en) | 2004-11-16 |
DE69928040D1 (de) | 2005-12-08 |
ES2252886T3 (es) | 2006-05-16 |
DE69928040T2 (de) | 2006-07-27 |
IL129620A0 (en) | 2000-02-29 |
AU2500999A (en) | 1999-11-11 |
US20030139574A1 (en) | 2003-07-24 |
DK0953576T3 (da) | 2006-03-20 |
CY1105683T1 (el) | 2010-12-22 |
IL129620A (en) | 2009-06-15 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |