ATE329624T1 - Technetium-99m markierte peptide zur bilderzeugung von thrombus - Google Patents

Technetium-99m markierte peptide zur bilderzeugung von thrombus

Info

Publication number
ATE329624T1
ATE329624T1 AT99124003T AT99124003T ATE329624T1 AT E329624 T1 ATE329624 T1 AT E329624T1 AT 99124003 T AT99124003 T AT 99124003T AT 99124003 T AT99124003 T AT 99124003T AT E329624 T1 ATE329624 T1 AT E329624T1
Authority
AT
Austria
Prior art keywords
reagents
thrombus
technetium
methods
labeled peptides
Prior art date
Application number
AT99124003T
Other languages
English (en)
Inventor
Richard T Dean
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of ATE329624T1 publication Critical patent/ATE329624T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99124003T 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus ATE329624T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88675292A 1992-05-21 1992-05-21

Publications (1)

Publication Number Publication Date
ATE329624T1 true ATE329624T1 (de) 2006-07-15

Family

ID=25389692

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93914023T ATE196094T1 (de) 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus
AT99124003T ATE329624T1 (de) 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT93914023T ATE196094T1 (de) 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus

Country Status (10)

Country Link
US (1) US5925331A (de)
EP (2) EP1004322B1 (de)
JP (2) JP2941057B2 (de)
AT (2) ATE196094T1 (de)
AU (1) AU677208B2 (de)
CA (1) CA2136330C (de)
DE (2) DE69334033D1 (de)
DK (1) DK0641222T3 (de)
ES (1) ES2150945T3 (de)
WO (1) WO1993023085A1 (de)

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US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
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US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
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US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
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AU687080B2 (en) * 1993-04-08 1998-02-19 Cis Bio International Radiolabeled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
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US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE69426035T2 (de) * 1993-07-28 2001-05-17 Diatide, Inc. Radiomarkierte glukane
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DE4337599A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst Metallbindende cysteinfreie Peptide für Diagnose und Therapie, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
DE69524580T2 (de) * 1994-03-18 2002-07-25 Diatide, Inc. Piperidyl-4-substituierte thyrosin-derivate als szintigraphische kontrastmittel zur diagnose von thrombosen
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IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
DE69536153D1 (de) * 1994-11-17 2011-05-05 Ich Productions Ltd Internalisierung von dna, unter verwendung von konjugaten des poly-l-lysins und eines peptidligands des integrin-rezeptors
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
AU3474997A (en) * 1996-06-10 1998-01-07 G.D. Searle & Co. Radiopharmaceutical compositions capable of localizing at sites of thrombus
US6028056A (en) * 1998-02-06 2000-02-22 Diatide, Inc. Pharmaceutical compositions for imaging and treating thrombi
SE523817C2 (sv) 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
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WO2001009188A1 (en) * 1999-07-29 2001-02-08 Dyax Corp. Binding moieties for fibrin
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
ES2719088T3 (es) 2001-07-10 2019-07-08 Ge Healthcare Ltd Compuestos con base peptídica para localizar receptores de integrina
US20040023981A1 (en) * 2002-07-24 2004-02-05 Yu Ren Salt forms with tyrosine kinase activity
EP1437145A1 (de) * 2003-01-07 2004-07-14 Schering AG Verbesserte szintigraphische bildgebende Mittel zur Darstellung von Infektionen und Entzündungen
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
GB0516091D0 (en) * 2005-08-04 2005-09-14 Haemostatix Ltd Therapeutic agent
RU2504331C1 (ru) * 2013-01-21 2014-01-20 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы Способ радионуклидной оценки степени ишемии при остром тромбозе магистральных артерий нижних конечностей у больных с двусторонним атеросклеротическим поражением артерий
CN108976284B (zh) * 2017-05-31 2021-11-30 首都医科大学 含Gly-Pro-Arg-Pro的五肽修饰的华法林,其合成,活性和应用
CN108976285B (zh) * 2017-05-31 2021-11-30 首都医科大学 Gly-Pro-Arg-Pro-AA修饰的华法林,其合成,活性和应用

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Also Published As

Publication number Publication date
EP0641222A1 (de) 1995-03-08
JPH10291939A (ja) 1998-11-04
DE69329382T2 (de) 2001-03-15
WO1993023085A1 (en) 1993-11-25
CA2136330A1 (en) 1993-11-25
JP3380738B2 (ja) 2003-02-24
DE69329382D1 (de) 2000-10-12
EP1004322B1 (de) 2006-06-14
JP2941057B2 (ja) 1999-08-25
ATE196094T1 (de) 2000-09-15
EP0641222B1 (de) 2000-09-06
CA2136330C (en) 2002-03-19
JPH07508289A (ja) 1995-09-14
DK0641222T3 (da) 2000-12-11
AU4384593A (en) 1993-12-13
EP1004322A3 (de) 2003-12-03
US5925331A (en) 1999-07-20
ES2150945T3 (es) 2000-12-16
AU677208B2 (en) 1997-04-17
DE69334033D1 (de) 2006-07-27
EP1004322A2 (de) 2000-05-31

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Legal Events

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