ATE328605T1 - Verwendung von insulin zur behandlung von knorpelkrankheiten - Google Patents
Verwendung von insulin zur behandlung von knorpelkrankheitenInfo
- Publication number
- ATE328605T1 ATE328605T1 AT01922571T AT01922571T ATE328605T1 AT E328605 T1 ATE328605 T1 AT E328605T1 AT 01922571 T AT01922571 T AT 01922571T AT 01922571 T AT01922571 T AT 01922571T AT E328605 T1 ATE328605 T1 AT E328605T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- administration
- cartilage
- injury
- repair
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 14
- 102000004877 Insulin Human genes 0.000 title abstract 7
- 108090001061 Insulin Proteins 0.000 title abstract 7
- 229940125396 insulin Drugs 0.000 title abstract 7
- 208000015100 cartilage disease Diseases 0.000 title 1
- 210000000845 cartilage Anatomy 0.000 abstract 5
- 208000027418 Wounds and injury Diseases 0.000 abstract 3
- 230000006378 damage Effects 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000014674 injury Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19210300P | 2000-03-24 | 2000-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE328605T1 true ATE328605T1 (de) | 2006-06-15 |
Family
ID=22708258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01922571T ATE328605T1 (de) | 2000-03-24 | 2001-03-22 | Verwendung von insulin zur behandlung von knorpelkrankheiten |
Country Status (11)
Country | Link |
---|---|
US (4) | US6689747B2 (de) |
EP (1) | EP1265630B1 (de) |
JP (2) | JP2003528149A (de) |
AT (1) | ATE328605T1 (de) |
AU (1) | AU4935701A (de) |
CA (1) | CA2402191C (de) |
DE (1) | DE60120372T2 (de) |
DK (1) | DK1265630T3 (de) |
ES (1) | ES2266187T3 (de) |
IL (1) | IL151408A (de) |
WO (1) | WO2001072323A2 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7019192B2 (en) * | 1998-02-27 | 2006-03-28 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US20050147609A1 (en) * | 1998-05-15 | 2005-07-07 | Genentech, Inc. | Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis |
JP2003528149A (ja) * | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
US7090865B2 (en) * | 2001-11-29 | 2006-08-15 | National Jewish Medical And Research Center | Composition and method for treating autoimmune hemolytic anemia |
US20040005999A1 (en) * | 2002-03-07 | 2004-01-08 | Andreasen Kasper Huus | Polyamino acid-based particle insulin preparation |
US20060204544A1 (en) * | 2002-05-20 | 2006-09-14 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US20040138116A1 (en) * | 2002-08-30 | 2004-07-15 | Vincent Geenen | Tolerogenic approach for type 1 diabetes |
US20070122487A1 (en) * | 2003-03-19 | 2007-05-31 | University Of Kentucky Research Foundation | (Poly(acryloyl-hydroxyethyl starch)-plga composition microspheres |
EP3572106A1 (de) | 2003-04-23 | 2019-11-27 | Valeritas, Inc. | Hydraulisch aktivierte pumpe für langzeitabgabe von medikamenten |
US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7488348B2 (en) * | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
US20040228897A1 (en) * | 2003-05-16 | 2004-11-18 | Zhang Ping Ye | Methods and apparatus for in vivo cell localization |
US20050142152A1 (en) * | 2003-12-30 | 2005-06-30 | Leshchiner Adelya K. | Polymeric materials, their preparation and use |
GB0402129D0 (en) * | 2004-01-30 | 2004-03-03 | King S College London | Therapeutic and diagnostic peptides |
US9089636B2 (en) * | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
JP4949241B2 (ja) * | 2004-07-12 | 2012-06-06 | イスト・テクノロジーズ・インコーポレイテッド | 組織マトリックスシステム |
US8512730B2 (en) * | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20090155229A1 (en) * | 2004-12-06 | 2009-06-18 | Avner Yayon | Chondrocyte-based implant for the delivery of therapeutic agents |
US7815926B2 (en) * | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
CA2631520A1 (en) * | 2005-12-07 | 2007-06-14 | Isto Technologies, Inc. | Cartilage repair methods |
US20070141160A1 (en) * | 2005-12-15 | 2007-06-21 | Brown Laura J | Method of treatment for osteoarthritis by local intra-articular injection of microparticles |
CN101460216B (zh) | 2006-03-30 | 2013-06-19 | 瓦莱里塔斯公司 | 多筒式流体递送器械 |
ES2545775T3 (es) * | 2007-02-05 | 2015-09-15 | Apellis Pharmaceuticals, Inc. | Análogos de compstatina para uso en el tratamiento de afecciones inflamatorias del sistema respiratorio |
US8435551B2 (en) * | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
CA2683698C (en) * | 2007-04-19 | 2013-09-10 | Hyun Hee Kwak | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
EP2147311A4 (de) * | 2007-04-26 | 2010-08-11 | Genera Istrazivanja D O O | Blut-biomarker für knochenbruch und knorpelverletzung |
US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
CA2708147A1 (en) * | 2007-12-05 | 2009-06-18 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
EP2265220A1 (de) | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Spongiosa-konstrukte, knorpelteilchen und kombinationen von spongiosa-konstrukten und knorpelteilchen |
PT2254906T (pt) | 2008-03-18 | 2017-01-03 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
KR20170023209A (ko) | 2008-05-05 | 2017-03-02 | 노비뮨 에스 에이 | 항-il-17a/il-17f 교차-반응성 항체 및 그의 사용 방법 |
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-
2001
- 2001-03-22 JP JP2001570284A patent/JP2003528149A/ja not_active Withdrawn
- 2001-03-22 US US09/815,229 patent/US6689747B2/en not_active Expired - Lifetime
- 2001-03-22 AT AT01922571T patent/ATE328605T1/de active
- 2001-03-22 EP EP01922571A patent/EP1265630B1/de not_active Expired - Lifetime
- 2001-03-22 DK DK01922571T patent/DK1265630T3/da active
- 2001-03-22 AU AU4935701A patent/AU4935701A/xx active Pending
- 2001-03-22 WO PCT/US2001/009230 patent/WO2001072323A2/en active IP Right Grant
- 2001-03-22 ES ES01922571T patent/ES2266187T3/es not_active Expired - Lifetime
- 2001-03-22 DE DE60120372T patent/DE60120372T2/de not_active Expired - Lifetime
- 2001-03-22 CA CA2402191A patent/CA2402191C/en not_active Expired - Fee Related
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2002
- 2002-08-21 IL IL151408A patent/IL151408A/en not_active IP Right Cessation
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2003
- 2003-12-17 US US10/740,098 patent/US7268112B2/en not_active Expired - Fee Related
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2006
- 2006-10-04 US US11/538,700 patent/US20070049516A1/en not_active Abandoned
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2010
- 2010-06-28 US US12/825,208 patent/US20100266698A1/en not_active Abandoned
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2012
- 2012-01-27 JP JP2012015753A patent/JP2012121896A/ja not_active Ceased
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DE60120372T2 (de) | 2007-07-05 |
EP1265630A2 (de) | 2002-12-18 |
EP1265630B1 (de) | 2006-06-07 |
IL151408A0 (en) | 2003-04-10 |
WO2001072323A2 (en) | 2001-10-04 |
US20100266698A1 (en) | 2010-10-21 |
US20020058614A1 (en) | 2002-05-16 |
US7268112B2 (en) | 2007-09-11 |
DK1265630T3 (da) | 2006-10-09 |
CA2402191C (en) | 2012-03-13 |
CA2402191A1 (en) | 2001-10-04 |
JP2012121896A (ja) | 2012-06-28 |
AU4935701A (en) | 2001-10-08 |
US6689747B2 (en) | 2004-02-10 |
DE60120372D1 (de) | 2006-07-20 |
US20040138101A1 (en) | 2004-07-15 |
ES2266187T3 (es) | 2007-03-01 |
IL151408A (en) | 2009-08-03 |
US20070049516A1 (en) | 2007-03-01 |
WO2001072323A3 (en) | 2002-06-06 |
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