ATE323110T1 - Verfahren zur herstellung von einem cyclodextrin - Google Patents
Verfahren zur herstellung von einem cyclodextrinInfo
- Publication number
- ATE323110T1 ATE323110T1 AT98304785T AT98304785T ATE323110T1 AT E323110 T1 ATE323110 T1 AT E323110T1 AT 98304785 T AT98304785 T AT 98304785T AT 98304785 T AT98304785 T AT 98304785T AT E323110 T1 ATE323110 T1 AT E323110T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclodextrin
- base
- residual
- alkyl sultone
- added
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 Sulfoalkyl ether Chemical compound 0.000 abstract 4
- 239000007858 starting material Substances 0.000 abstract 2
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5149797P | 1997-07-01 | 1997-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE323110T1 true ATE323110T1 (de) | 2006-04-15 |
Family
ID=21971666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98304785T ATE323110T1 (de) | 1997-07-01 | 1998-06-17 | Verfahren zur herstellung von einem cyclodextrin |
Country Status (10)
Country | Link |
---|---|
US (1) | US6153746A (de) |
EP (1) | EP0889056B1 (de) |
JP (1) | JP3272669B2 (de) |
AT (1) | ATE323110T1 (de) |
BR (1) | BR9802331A (de) |
CA (1) | CA2241774C (de) |
DE (1) | DE69834154T2 (de) |
DK (1) | DK0889056T3 (de) |
ES (1) | ES2257795T3 (de) |
PT (1) | PT889056E (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6479467B1 (en) * | 1999-12-16 | 2002-11-12 | Eastman Chemical Company | Cyclodextrin ethers |
SI1278549T1 (sl) * | 2000-05-02 | 2009-04-30 | Theravance Inc | Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik |
US20030028014A1 (en) * | 2001-04-26 | 2003-02-06 | Chris Sikorski | Agglomerated modified cyclodextrin and process for making same |
JP2004531537A (ja) * | 2001-05-01 | 2004-10-14 | ファイザー・プロダクツ・インク | 一様な薬剤分布と効力を有する低用量製薬組成物の製造方法 |
CA2543443A1 (en) * | 2003-10-31 | 2005-05-12 | The University Of Kansas | Sulfoalkyl ether-alkyl ether cyclodextrin derivatives |
RU2390330C2 (ru) | 2003-12-31 | 2010-05-27 | Сайдекс, Инк. | Ингаляционная препаративная форма, содержащая простой сульфоалкиловый эфир гамма-циклодекстрина и кортикостероид |
US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
MXPA06012240A (es) | 2004-04-23 | 2007-01-31 | Cydex Inc | Formulacion para inhalador de polvo seco que contiene eter sulfoalquilico-ciclodextrina. |
US20100204178A1 (en) | 2006-10-02 | 2010-08-12 | James Cloyd | Novel parenteral carbamazepine formulation |
AU2011204957B2 (en) * | 2005-10-26 | 2013-12-05 | Cydex Pharmaceuticals, Inc | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
MX348982B (es) | 2005-10-26 | 2017-07-06 | Cydex Pharmaceuticals Inc | Composiciones de eter sulfoalquilico-ciclodextrina y metodos de preparacion de las mismas. |
CN102327617B (zh) * | 2005-10-26 | 2014-08-20 | 锡德克斯药物公司 | 磺基烷基醚环糊精组合物和其制备方法 |
US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
US20090239942A1 (en) * | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
WO2008065142A1 (en) * | 2006-11-29 | 2008-06-05 | N.V. Organon | Stabilized solution of rocuronium comprising a sulfoalkyl-ether-beta-cyclodextrin derivative |
EP3766493B1 (de) | 2007-04-27 | 2023-08-23 | CyDex Pharmaceuticals, Inc. | Methode zur stabilisierung von clopidogrel unter verwendung von sulfoalkylethercyclodextrin |
ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
US7635773B2 (en) * | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
WO2010048298A1 (en) | 2008-10-21 | 2010-04-29 | Proteolix, Inc. | Combination therapy with peptide epoxyketones |
US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
JP5808739B2 (ja) * | 2009-05-13 | 2015-11-10 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プラスグレル及びシクロデキストリン誘導体を含む医薬組成物並びにその製造方法及び使用方法 |
NZ596515A (en) | 2009-05-29 | 2014-03-28 | Cydex Pharmaceuticals Inc | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠(olopatadine)眼用組成物 |
TW201336527A (zh) | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
DK2814849T3 (da) | 2012-02-15 | 2020-03-09 | Cydex Pharmaceuticals Inc | Fremgangsmåde til fremstilling af cyclodextrin-derivater |
CA2865950C (en) | 2012-02-28 | 2016-12-20 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
CA2869056C (en) * | 2012-03-30 | 2020-02-25 | Sapiotec Gmbh | Anthocyanidin complex |
EP4410374A2 (de) | 2012-05-08 | 2024-08-07 | Onyx Therapeutics, Inc. | Verfahren zur herstellung von cyclodextrinkomplexen zur formulierung von peptidproteasomhemmern |
NZ707323A (en) * | 2012-10-22 | 2018-11-30 | Cydex Pharmaceuticals Inc | Alkylated cyclodextrin compositions and processes for preparing and using the same |
GB201312737D0 (en) * | 2013-07-17 | 2013-08-28 | Univ Greenwich | Cyclodextrin |
CN103694376B (zh) * | 2014-01-10 | 2016-04-13 | 凯莱英医药集团(天津)股份有限公司 | 一种制备磺丁基醚-β-环糊精的方法 |
WO2016029179A1 (en) | 2014-08-22 | 2016-02-25 | Cydex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
CA2980170A1 (en) | 2015-03-19 | 2016-09-22 | Cydex Pharmaceuticals, Inc. | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same |
CN104892797B (zh) * | 2015-05-28 | 2017-03-22 | 天津大学 | 特定平均取代度磺丁基醚‑β‑环糊精的合成方法 |
CN106749770A (zh) * | 2015-11-20 | 2017-05-31 | 天津市通航科技有限公司 | 一种微波辐射/碱耦合制备不同取代度磺丁基醚-β-环糊精的方法 |
US11274164B2 (en) | 2017-02-07 | 2022-03-15 | Biophore India Pharmaceuticals Pvt. Ltd. | Method for the preparation of sulfobutylether beta cyclodextrin sodium |
EP3618825A4 (de) | 2017-05-03 | 2021-01-20 | Cydex Pharmaceuticals, Inc. | Zusammensetzung mit cyclodextrin und busulfan |
JP7336657B2 (ja) | 2018-10-15 | 2023-09-01 | 国立大学法人大阪大学 | 環状オリゴ糖及びその製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3426011A (en) * | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
-
1998
- 1998-06-17 DK DK98304785T patent/DK0889056T3/da active
- 1998-06-17 AT AT98304785T patent/ATE323110T1/de active
- 1998-06-17 PT PT98304785T patent/PT889056E/pt unknown
- 1998-06-17 DE DE69834154T patent/DE69834154T2/de not_active Expired - Lifetime
- 1998-06-17 EP EP98304785A patent/EP0889056B1/de not_active Expired - Lifetime
- 1998-06-17 ES ES98304785T patent/ES2257795T3/es not_active Expired - Lifetime
- 1998-06-25 JP JP17883198A patent/JP3272669B2/ja not_active Expired - Lifetime
- 1998-06-29 US US09/106,983 patent/US6153746A/en not_active Expired - Lifetime
- 1998-06-29 CA CA002241774A patent/CA2241774C/en not_active Expired - Lifetime
- 1998-07-01 BR BR9802331-4A patent/BR9802331A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0889056B1 (de) | 2006-04-12 |
JP3272669B2 (ja) | 2002-04-08 |
ES2257795T3 (es) | 2006-08-01 |
DK0889056T3 (da) | 2006-07-17 |
EP0889056A3 (de) | 1999-04-07 |
DE69834154D1 (de) | 2006-05-24 |
CA2241774A1 (en) | 1999-01-01 |
DE69834154T2 (de) | 2007-01-25 |
PT889056E (pt) | 2006-07-31 |
US6153746A (en) | 2000-11-28 |
JPH1160610A (ja) | 1999-03-02 |
BR9802331A (pt) | 2000-09-05 |
EP0889056A2 (de) | 1999-01-07 |
CA2241774C (en) | 2002-06-25 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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