ATE322495T1 - Verfahren zur herstellung von kristallinem n- formimidoylthienamycin-monohydrat (imipenem- monohydrat) - Google Patents

Verfahren zur herstellung von kristallinem n- formimidoylthienamycin-monohydrat (imipenem- monohydrat)

Info

Publication number
ATE322495T1
ATE322495T1 AT01980805T AT01980805T ATE322495T1 AT E322495 T1 ATE322495 T1 AT E322495T1 AT 01980805 T AT01980805 T AT 01980805T AT 01980805 T AT01980805 T AT 01980805T AT E322495 T1 ATE322495 T1 AT E322495T1
Authority
AT
Austria
Prior art keywords
monohydrate
formimidoylthienamycin
imipenem
producing crystalline
crystalline
Prior art date
Application number
AT01980805T
Other languages
German (de)
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Ram Chander Aryan
Bishwa Prakash Rai
Seema Ahuja
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11097114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE322495(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of ATE322495T1 publication Critical patent/ATE322495T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01980805T 2000-11-03 2001-11-05 Verfahren zur herstellung von kristallinem n- formimidoylthienamycin-monohydrat (imipenem- monohydrat) ATE322495T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN983DE2000 IN191798B (h) 2000-11-03 2000-11-03

Publications (1)

Publication Number Publication Date
ATE322495T1 true ATE322495T1 (de) 2006-04-15

Family

ID=11097114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01980805T ATE322495T1 (de) 2000-11-03 2001-11-05 Verfahren zur herstellung von kristallinem n- formimidoylthienamycin-monohydrat (imipenem- monohydrat)

Country Status (19)

Country Link
US (1) US7078534B2 (h)
EP (1) EP1334105B1 (h)
JP (1) JP2004525084A (h)
KR (1) KR20030059812A (h)
CN (1) CN100445284C (h)
AT (1) ATE322495T1 (h)
AU (1) AU2002212591A1 (h)
BG (1) BG107852A (h)
CA (1) CA2427762C (h)
DE (1) DE60118593D1 (h)
DK (1) DK1334105T3 (h)
EA (1) EA006442B1 (h)
EE (1) EE200300206A (h)
ES (1) ES2261494T3 (h)
IN (1) IN191798B (h)
MX (1) MXPA03003916A (h)
PT (1) PT1334105E (h)
WO (1) WO2002036594A1 (h)
ZA (1) ZA200303338B (h)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03010547A (es) * 2001-05-18 2004-05-27 Ranbaxy Lab Ltd Proceso para la preparacion de cilastatina sodica amorfa.
JP2005508860A (ja) * 2001-05-18 2005-04-07 ランバクシー ラボラトリーズ リミテッド イミペネムの製造方法
JP2005514323A (ja) 2001-05-18 2005-05-19 ランバクシー ラボラトリーズ リミテッド 結晶イミペネムの単離方法
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
CN1608066A (zh) 2001-11-16 2005-04-20 兰贝克赛实验室有限公司 结晶亚胺培南的制备方法
US6537985B1 (en) * 2001-11-30 2003-03-25 Phoenix Scientific, Inc. Antibiotic formulation and a method of making this formulation
AU2004296261B2 (en) * 2003-12-09 2007-08-23 Choongwae Pharm. Co. A new process for preparation of imipenem
KR100848752B1 (ko) * 2006-11-10 2008-07-25 제일약품주식회사 티에나마이신 용매화합물 및 그의 제조방법
KR100848751B1 (ko) * 2006-11-10 2008-07-25 제일약품주식회사 이미페넴의 제조방법
WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN108623598A (zh) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 一种亚胺培南中间体及亚胺培南的制备方法
CN111413427A (zh) * 2020-04-08 2020-07-14 苏州和合医学检验有限公司 超滤前处理高效液相色谱测定血浆中亚胺培南含量的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
JP3048196B2 (ja) 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
RU2130938C1 (ru) 1991-10-01 1999-05-27 Проктер энд Гэмбл Фармасьютикалз, Инк. Способ получения хинолиниллактамов или их солей
NO304981B1 (no) 1992-09-09 1999-03-15 Sankyo Co FremgangsmÕte for fremstilling av karbapenem- og penemforbindelser, samt nye forbindelser involvert i fremgangsmÕten
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics

Also Published As

Publication number Publication date
AU2002212591A1 (en) 2002-05-15
EP1334105B1 (en) 2006-04-05
US7078534B2 (en) 2006-07-18
BG107852A (bg) 2004-01-30
ES2261494T3 (es) 2006-11-16
KR20030059812A (ko) 2003-07-10
JP2004525084A (ja) 2004-08-19
PT1334105E (pt) 2006-08-31
EA200300520A1 (ru) 2003-10-30
US20040054167A1 (en) 2004-03-18
WO2002036594A1 (en) 2002-05-10
MXPA03003916A (es) 2004-01-29
CN1481384A (zh) 2004-03-10
IN191798B (h) 2004-01-03
CN100445284C (zh) 2008-12-24
EE200300206A (et) 2003-10-15
ZA200303338B (en) 2004-03-09
EA006442B1 (ru) 2005-12-29
CA2427762A1 (en) 2002-05-10
DE60118593D1 (de) 2006-05-18
EP1334105A1 (en) 2003-08-13
CA2427762C (en) 2009-10-20
DK1334105T3 (da) 2006-08-14

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