ATE321860T1 - Salmonella impfstoffe - Google Patents
Salmonella impfstoffeInfo
- Publication number
- ATE321860T1 ATE321860T1 AT94923374T AT94923374T ATE321860T1 AT E321860 T1 ATE321860 T1 AT E321860T1 AT 94923374 T AT94923374 T AT 94923374T AT 94923374 T AT94923374 T AT 94923374T AT E321860 T1 ATE321860 T1 AT E321860T1
- Authority
- AT
- Austria
- Prior art keywords
- mutation
- phop
- virulence
- salmonella vaccines
- genes
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000035772 mutation Effects 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000001018 virulence Effects 0.000 abstract 2
- 108700005078 Synthetic Genes Proteins 0.000 abstract 1
- -1 aromatic amino acid Chemical class 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/42—Salmonella
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/090,526 US5599537A (en) | 1990-12-18 | 1993-07-09 | Salmonella virulence genes |
US08/271,354 US5695983A (en) | 1990-12-18 | 1994-07-06 | Salmonella vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE321860T1 true ATE321860T1 (de) | 2006-04-15 |
Family
ID=26782369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94923374T ATE321860T1 (de) | 1993-07-09 | 1994-07-07 | Salmonella impfstoffe |
Country Status (12)
Country | Link |
---|---|
US (1) | US5695983A (de) |
EP (1) | EP0717777B1 (de) |
CN (1) | CN1130923A (de) |
AT (1) | ATE321860T1 (de) |
AU (1) | AU694948B2 (de) |
CA (1) | CA2166787A1 (de) |
DE (1) | DE69434680T2 (de) |
DK (1) | DK0717777T3 (de) |
ES (1) | ES2262134T3 (de) |
PT (1) | PT717777E (de) |
TW (1) | TW493987B (de) |
WO (1) | WO1995002048A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843426A (en) * | 1990-12-18 | 1998-12-01 | The General Hospital Corporation | Salmonella vaccines |
US5599537A (en) * | 1990-12-18 | 1997-02-04 | The General Hospital Corporation | Salmonella virulence genes |
US6136325A (en) * | 1993-04-09 | 2000-10-24 | Lohmann Animal Health Gmbh & Co. Kg | Live vaccine constituting minor risk for humans |
US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
ATE312934T1 (de) * | 1995-06-07 | 2005-12-15 | Univ Washington | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
CA2237581A1 (en) * | 1995-11-14 | 1997-05-22 | The General Hospital Corporation | Salmonella secreted proteins and uses thereof |
US6861247B1 (en) * | 1995-11-14 | 2005-03-01 | The General Hospital Corporation | Salmonella secreted proteins and uses thereof |
EP0835928A1 (de) * | 1996-10-11 | 1998-04-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | Helicobacter Pylori Lebendimpfstoff |
EP1012232B1 (de) | 1997-09-10 | 2009-10-28 | Vion Pharmaceuticals, Inc. | Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz |
US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
US6413768B1 (en) | 1998-12-02 | 2002-07-02 | University Of Maryland | Expression plasmids |
US8076130B2 (en) * | 1998-12-02 | 2011-12-13 | University Of Maryland, Baltimore | Plasmid maintenance system for antigen delivery |
DE69935927T2 (de) | 1998-12-02 | 2008-01-10 | University Of Maryland, Baltimore | Plasmidstabilisierungssystem für die verabreichung von antigenen |
EP1173790A2 (de) | 1999-03-01 | 2002-01-23 | Boston Innovative Optics, Inc. | Vorrichtung und verfahren zur erhöhung der tiefenschärfe des menschlichen auges |
WO2001019974A2 (en) * | 1999-09-10 | 2001-03-22 | The Secretary Of State For Defence | Recombinant microorganisms |
US6962696B1 (en) | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
ES2192949B1 (es) | 2001-07-31 | 2004-08-16 | Universidad De Zaragoza. | Disminucion de la virulencia de mycobacterium tuberculosis por la inactivacion del gen phop. |
US7195757B2 (en) * | 2002-04-15 | 2007-03-27 | Washington University | Modulation of immune responses to foreign antigens expressed by recombinant attenuated bacterial vectors |
US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
US20050046794A1 (en) | 2003-06-17 | 2005-03-03 | Silvestrini Thomas A. | Method and apparatus for aligning a mask with the visual axis of an eye |
US20100003284A1 (en) * | 2003-08-29 | 2010-01-07 | The Board Of Governors For Higher Education, State Of Phode Island And Providence Plantations | Live attenuated aldolase-negative bacterial vaccine |
US7976577B2 (en) | 2005-04-14 | 2011-07-12 | Acufocus, Inc. | Corneal optic formed of degradation resistant polymer |
US20080206758A1 (en) * | 2006-10-17 | 2008-08-28 | Lcm Technologies, Inc. | Polynucleic acid-attached particles and their use in genomic analysis |
EP2150616A4 (de) | 2007-05-10 | 2011-07-27 | Univ Arizona | Geregelte antigensynthese und/oder geregelte attenuation zur verbesserung der impfstoff immunogenität und/oder -sicherheit |
US8252897B2 (en) * | 2007-06-21 | 2012-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
US8470314B2 (en) * | 2008-02-29 | 2013-06-25 | Angelica Therapeutics, Inc. | Modified toxins |
WO2010045620A1 (en) * | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
ES2970433T3 (es) | 2009-08-13 | 2024-05-28 | Acufocus Inc | Método de fabricación de implantes intraoculares con máscara y lentes |
USD656526S1 (en) | 2009-11-10 | 2012-03-27 | Acufocus, Inc. | Ocular mask |
US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
US9545303B2 (en) | 2011-12-02 | 2017-01-17 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
CN102676419B (zh) * | 2011-12-06 | 2014-03-26 | 河南科技大学 | 一种伤寒沙门氏菌基因缺失菌株及由其制备的疫苗和应用 |
US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
CA2902905A1 (en) | 2013-03-15 | 2014-09-25 | Claude Geoffrey Davis | Modified toxins |
CN104560855B (zh) * | 2015-01-07 | 2018-03-02 | 四川农业大学 | 缺失phoP的鸭疫里默氏杆菌CH1减毒菌株及构建方法 |
CN104694432B (zh) * | 2015-03-13 | 2018-03-09 | 华中农业大学 | 缺失phoQ和rpoS基因的都柏林沙门氏菌及应用 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CN112546210A (zh) * | 2020-12-15 | 2021-03-26 | 南京农业大学 | 一种沙门菌灭活疫苗的制备方法及应用 |
CN116497039B (zh) * | 2022-08-30 | 2024-04-09 | 四川大学华西医院 | 一类phoQ基因突变体、应用及其验证方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210035A (en) * | 1980-05-19 | 1993-05-11 | Board Of Trustees Of Leland Stanford Jr. University | Non-reventing live vaccines |
US4837151A (en) * | 1980-05-19 | 1989-06-06 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford University | Live vaccines comprising two mutations and foreign antigen |
US4550081A (en) * | 1980-05-19 | 1985-10-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Non-reverting salmonella |
US5077044A (en) * | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
US4735801A (en) * | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
US4764370A (en) * | 1984-09-12 | 1988-08-16 | Scripps Clinic And Research Foundation | Vaccine utilizing an avirulent strain of Salmonella typhimurium |
ES2090129T3 (es) * | 1989-03-31 | 1996-10-16 | Univ Washington | Vacunas que contienen microorganismos tipo phop avirulentos. |
DE69132058D1 (de) * | 1990-12-18 | 2000-04-20 | Gen Hospital Corp | Verbesserte impfstoffe |
WO1992017785A1 (en) * | 1991-03-29 | 1992-10-15 | The General Hospital Corporation | Detection of salmonella |
-
1994
- 1994-07-06 US US08/271,354 patent/US5695983A/en not_active Expired - Fee Related
- 1994-07-07 WO PCT/US1994/007658 patent/WO1995002048A1/en active IP Right Grant
- 1994-07-07 CN CN94193330A patent/CN1130923A/zh active Pending
- 1994-07-07 DK DK94923374T patent/DK0717777T3/da active
- 1994-07-07 AU AU73259/94A patent/AU694948B2/en not_active Ceased
- 1994-07-07 ES ES94923374T patent/ES2262134T3/es not_active Expired - Lifetime
- 1994-07-07 CA CA002166787A patent/CA2166787A1/en not_active Abandoned
- 1994-07-07 AT AT94923374T patent/ATE321860T1/de not_active IP Right Cessation
- 1994-07-07 DE DE69434680T patent/DE69434680T2/de not_active Expired - Fee Related
- 1994-07-07 EP EP94923374A patent/EP0717777B1/de not_active Expired - Lifetime
- 1994-07-07 PT PT94923374T patent/PT717777E/pt unknown
- 1994-12-09 TW TW083111470A patent/TW493987B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1995002048A1 (en) | 1995-01-19 |
CN1130923A (zh) | 1996-09-11 |
ES2262134T3 (es) | 2006-11-16 |
DK0717777T3 (da) | 2006-08-07 |
EP0717777A4 (de) | 1998-06-10 |
DE69434680D1 (de) | 2006-05-18 |
AU7325994A (en) | 1995-02-06 |
AU694948B2 (en) | 1998-08-06 |
TW493987B (en) | 2002-07-11 |
EP0717777A1 (de) | 1996-06-26 |
US5695983A (en) | 1997-12-09 |
CA2166787A1 (en) | 1995-01-19 |
PT717777E (pt) | 2006-06-30 |
DE69434680T2 (de) | 2007-01-04 |
EP0717777B1 (de) | 2006-03-29 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 0717777 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |