ATE316970T1 - 8-(2,2,2-trifluoroethyl)-8-azabicyclo(3.2.1)oct n-3-on verwendbar als zwischenprodukt für serotonin-4-rezeptor stimulierende chinolincarbonsäure- derivate - Google Patents

8-(2,2,2-trifluoroethyl)-8-azabicyclo(3.2.1)oct n-3-on verwendbar als zwischenprodukt für serotonin-4-rezeptor stimulierende chinolincarbonsäure- derivate

Info

Publication number
ATE316970T1
ATE316970T1 AT99123695T AT99123695T ATE316970T1 AT E316970 T1 ATE316970 T1 AT E316970T1 AT 99123695 T AT99123695 T AT 99123695T AT 99123695 T AT99123695 T AT 99123695T AT E316970 T1 ATE316970 T1 AT E316970T1
Authority
AT
Austria
Prior art keywords
azabicyclo
serotonin
trifluoroethyl
oct
acid derivatives
Prior art date
Application number
AT99123695T
Other languages
English (en)
Inventor
Yutaka Ohuchi
Masaji Suzuki
Hajime Asanuma
Sadakazu Yokomori
Katsuo Hatayama
Original Assignee
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Ltd filed Critical Syngenta Ltd
Application granted granted Critical
Publication of ATE316970T1 publication Critical patent/ATE316970T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT99123695T 1994-05-18 1995-05-18 8-(2,2,2-trifluoroethyl)-8-azabicyclo(3.2.1)oct n-3-on verwendbar als zwischenprodukt für serotonin-4-rezeptor stimulierende chinolincarbonsäure- derivate ATE316970T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10317794 1994-05-18

Publications (1)

Publication Number Publication Date
ATE316970T1 true ATE316970T1 (de) 2006-02-15

Family

ID=14347238

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95918742T ATE200286T1 (de) 1994-05-18 1995-05-18 Chinolincarbonsäure-derivate
AT99123695T ATE316970T1 (de) 1994-05-18 1995-05-18 8-(2,2,2-trifluoroethyl)-8-azabicyclo(3.2.1)oct n-3-on verwendbar als zwischenprodukt für serotonin-4-rezeptor stimulierende chinolincarbonsäure- derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95918742T ATE200286T1 (de) 1994-05-18 1995-05-18 Chinolincarbonsäure-derivate

Country Status (11)

Country Link
US (1) US5753673A (de)
EP (2) EP0710662B1 (de)
JP (1) JP3829879B2 (de)
KR (1) KR960703907A (de)
AT (2) ATE200286T1 (de)
AU (1) AU685632B2 (de)
CA (1) CA2167055A1 (de)
DE (2) DE69534768T2 (de)
DK (1) DK1018513T3 (de)
ES (1) ES2252907T3 (de)
WO (1) WO1995031455A1 (de)

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CA2184366A1 (en) * 1994-02-28 1995-08-31 Yutaka Ohuchi Heterocyclic compound
EP1021443A4 (de) * 1995-11-13 2001-02-07 Smithkline Beecham Corp Hamoregulationische verbindungen
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
CA2545092C (en) * 2003-11-24 2010-08-17 Pfizer Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7407966B2 (en) 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
DE602005014566D1 (de) * 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
BRPI0519708A2 (pt) * 2004-12-22 2009-03-10 Theravance Inc compostos de indazol-carboxamida
JP2008530225A (ja) * 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
JP5042043B2 (ja) * 2005-03-02 2012-10-03 セラヴァンス， インコーポレーテッド ５−ｈｔ４レセプターアゴニストであるキノリン化合物
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
EP1902053B1 (de) * 2005-06-07 2011-01-12 Theravance, Inc. Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
US7487406B2 (en) * 2005-11-29 2009-02-03 International Business Machines Corporation Systems, methods, and media for managing software defects
ATE509021T1 (de) * 2006-02-16 2011-05-15 Theravance Inc Verfahren zur herstellung von zwischenverbindungen zu 5-ht4-rezeptoragonist- verbindungen
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2445877B1 (de) 2008-12-03 2014-07-23 Nanotherapeutics, Inc. Bicyclische verbindungen und verfahren zu deren herstellung und deren verwendung
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
WO2011116491A1 (zh) * 2010-03-22 2011-09-29 北京世纪迈劲生物科技有限公司 制备二苯乙醇酸去甲托品酯和其盐的方法及其中所用的中间体
JP5767099B2 (ja) * 2011-06-16 2015-08-19 日本曹達株式会社 環状アミン化合物および有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
EP0564650B1 (de) * 1990-12-28 1995-09-20 Kyowa Hakko Kogyo Co., Ltd. Chinolinderivat
EP0670319A4 (de) * 1992-11-20 1996-01-17 Thaisho Pharmaceutical Co Ltd Heterocyclische verbindungen.

Also Published As

Publication number Publication date
AU685632B2 (en) 1998-01-22
US5753673A (en) 1998-05-19
DE69520545T2 (de) 2001-08-09
EP1018513A3 (de) 2004-07-21
EP1018513B1 (de) 2006-02-01
DE69520545D1 (de) 2001-05-10
EP0710662A1 (de) 1996-05-08
CA2167055A1 (en) 1995-11-23
JPH0834784A (ja) 1996-02-06
KR960703907A (ko) 1996-08-31
WO1995031455A1 (fr) 1995-11-23
ES2252907T3 (es) 2006-05-16
AU2454895A (en) 1995-12-05
EP0710662A4 (de) 1996-09-18
ATE200286T1 (de) 2001-04-15
EP1018513A2 (de) 2000-07-12
DE69534768D1 (de) 2006-04-13
EP0710662B1 (de) 2001-04-04
JP3829879B2 (ja) 2006-10-04
DE69534768T2 (de) 2007-02-01
DK1018513T3 (da) 2006-04-03

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