DE69534768D1 - 8-(2,2,2-Trifluoroethyl)-8-azabicycloÄ3.2.1Üoctan-3-on verwendbar als Zwischenprodukt für Serotonin-4-Rezeptor stimulierende Chinolincarbonsäure-Derivate - Google Patents

8-(2,2,2-Trifluoroethyl)-8-azabicycloÄ3.2.1Üoctan-3-on verwendbar als Zwischenprodukt für Serotonin-4-Rezeptor stimulierende Chinolincarbonsäure-Derivate

Info

Publication number
DE69534768D1
DE69534768D1 DE69534768T DE69534768T DE69534768D1 DE 69534768 D1 DE69534768 D1 DE 69534768D1 DE 69534768 T DE69534768 T DE 69534768T DE 69534768 T DE69534768 T DE 69534768T DE 69534768 D1 DE69534768 D1 DE 69534768D1
Authority
DE
Germany
Prior art keywords
useful
serotonin
trifluoroethyl
carboxylic acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534768T
Other languages
English (en)
Other versions
DE69534768T2 (de
Inventor
Yutaka Ohuchi
Masaji Suzuki
Hajime Asanuma
Sadakazu Yokomori
Katsuo Hatayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Ltd filed Critical Syngenta Ltd
Publication of DE69534768D1 publication Critical patent/DE69534768D1/de
Application granted granted Critical
Publication of DE69534768T2 publication Critical patent/DE69534768T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE69534768T 1994-05-18 1995-05-18 8-(2,2,2-Trifluoroethyl)-8-azabicycloÄ3.2.1Üoctan-3-on verwendbar als Zwischenprodukt für Serotonin-4-Rezeptor stimulierende Chinolincarbonsäure-Derivate Expired - Fee Related DE69534768T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10317794 1994-05-18
JP10317794 1994-05-18

Publications (2)

Publication Number Publication Date
DE69534768D1 true DE69534768D1 (de) 2006-04-13
DE69534768T2 DE69534768T2 (de) 2007-02-01

Family

ID=14347238

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69534768T Expired - Fee Related DE69534768T2 (de) 1994-05-18 1995-05-18 8-(2,2,2-Trifluoroethyl)-8-azabicycloÄ3.2.1Üoctan-3-on verwendbar als Zwischenprodukt für Serotonin-4-Rezeptor stimulierende Chinolincarbonsäure-Derivate
DE69520545T Expired - Fee Related DE69520545T2 (de) 1994-05-18 1995-05-18 Chinolincarbonsäure-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69520545T Expired - Fee Related DE69520545T2 (de) 1994-05-18 1995-05-18 Chinolincarbonsäure-derivate

Country Status (11)

Country Link
US (1) US5753673A (de)
EP (2) EP0710662B1 (de)
JP (1) JP3829879B2 (de)
KR (1) KR960703907A (de)
AT (2) ATE316970T1 (de)
AU (1) AU685632B2 (de)
CA (1) CA2167055A1 (de)
DE (2) DE69534768T2 (de)
DK (1) DK1018513T3 (de)
ES (1) ES2252907T3 (de)
WO (1) WO1995031455A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023147A1 (fr) * 1994-02-28 1995-08-31 Taisho Pharmaceutical Co., Ltd. Compose heterocyclique
WO1997018210A1 (en) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
CA2545092C (en) * 2003-11-24 2010-08-17 Pfizer Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7488736B2 (en) 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
WO2006052640A1 (en) * 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
NZ555180A (en) * 2004-12-22 2010-09-30 Theravance Inc Indazole-carboxamide compounds useful as 5-HT4 receptor agonists
JP2008530225A (ja) * 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
NZ560828A (en) * 2005-03-02 2011-01-28 Theravance Inc Quinolinone compounds as 5-HT4 receptor agonists
TWI377206B (en) 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
ATE495171T1 (de) * 2005-06-07 2011-01-15 Theravance Inc Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
US7487406B2 (en) * 2005-11-29 2009-02-03 International Business Machines Corporation Systems, methods, and media for managing software defects
CN101384588B (zh) * 2006-02-16 2011-08-31 施万制药 制备5-ht4受体激动剂化合物的中间体的方法
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2010065743A2 (en) 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
WO2011116491A1 (zh) * 2010-03-22 2011-09-29 北京世纪迈劲生物科技有限公司 制备二苯乙醇酸去甲托品酯和其盐的方法及其中所用的中间体
JP5767099B2 (ja) * 2011-06-16 2015-08-19 日本曹達株式会社 環状アミン化合物および有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
DE69113284T2 (de) * 1990-12-28 1996-02-22 Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo Chinolinderivat.
AU5161593A (en) * 1992-11-20 1994-06-22 Taisho Pharmaceutical Co., Ltd. Heterocyclic compound

Also Published As

Publication number Publication date
US5753673A (en) 1998-05-19
AU685632B2 (en) 1998-01-22
ATE200286T1 (de) 2001-04-15
WO1995031455A1 (fr) 1995-11-23
DE69534768T2 (de) 2007-02-01
JP3829879B2 (ja) 2006-10-04
DE69520545D1 (de) 2001-05-10
DK1018513T3 (da) 2006-04-03
AU2454895A (en) 1995-12-05
EP1018513A2 (de) 2000-07-12
EP1018513B1 (de) 2006-02-01
EP1018513A3 (de) 2004-07-21
DE69520545T2 (de) 2001-08-09
CA2167055A1 (en) 1995-11-23
EP0710662A4 (de) 1996-09-18
ES2252907T3 (es) 2006-05-16
JPH0834784A (ja) 1996-02-06
KR960703907A (ko) 1996-08-31
EP0710662A1 (de) 1996-05-08
EP0710662B1 (de) 2001-04-04
ATE316970T1 (de) 2006-02-15

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