ATE315411T1 - Verfahren zur radiolabeling ein somatostatin peptidanalog, das eine disulfidbindung enthält mit einem radioisotop des rheniums und ihre therapeutische anwendungen - Google Patents
Verfahren zur radiolabeling ein somatostatin peptidanalog, das eine disulfidbindung enthält mit einem radioisotop des rheniums und ihre therapeutische anwendungenInfo
- Publication number
- ATE315411T1 ATE315411T1 AT96916556T AT96916556T ATE315411T1 AT E315411 T1 ATE315411 T1 AT E315411T1 AT 96916556 T AT96916556 T AT 96916556T AT 96916556 T AT96916556 T AT 96916556T AT E315411 T1 ATE315411 T1 AT E315411T1
- Authority
- AT
- Austria
- Prior art keywords
- somatostatin
- methods
- radioisotope
- derived peptides
- disulfide bond
- Prior art date
Links
- 108010056088 Somatostatin Proteins 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 6
- 238000000163 radioactive labelling Methods 0.000 title 1
- 229910052702 rhenium Inorganic materials 0.000 title 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 9
- 102000005157 Somatostatin Human genes 0.000 abstract 8
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 8
- 229960000553 somatostatin Drugs 0.000 abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 150000002500 ions Chemical class 0.000 abstract 2
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44745395A | 1995-05-23 | 1995-05-23 | |
US1102796P | 1996-02-02 | 1996-02-02 | |
US08/651,179 US5985240A (en) | 1989-08-09 | 1996-05-21 | Peptide radiopharmaceutical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE315411T1 true ATE315411T1 (de) | 2006-02-15 |
Family
ID=27359346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96916556T ATE315411T1 (de) | 1995-05-23 | 1996-05-22 | Verfahren zur radiolabeling ein somatostatin peptidanalog, das eine disulfidbindung enthält mit einem radioisotop des rheniums und ihre therapeutische anwendungen |
Country Status (8)
Country | Link |
---|---|
US (1) | US5985240A (de) |
EP (1) | EP0827412B1 (de) |
JP (1) | JP2000515847A (de) |
AT (1) | ATE315411T1 (de) |
AU (1) | AU5926496A (de) |
CA (1) | CA2219492A1 (de) |
DE (1) | DE69635732T2 (de) |
WO (1) | WO1996037239A1 (de) |
Families Citing this family (18)
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US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
CN1072509C (zh) * | 1998-05-29 | 2001-10-10 | 中国科学院上海原子核研究所 | Re-188-硫化铼混悬液制剂、制备方法及其应用 |
US6256447B1 (en) * | 1998-12-31 | 2001-07-03 | Physical Optics Corporation | Backlight for correcting diagonal line distortion |
US6358491B1 (en) | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
EP1365813A4 (de) * | 2001-02-26 | 2006-03-22 | Bristol Myers Squibb Pharma Co | Analoge der ascorbinsäure für metalloradiopharmaka |
EP1575496A4 (de) * | 2002-04-05 | 2008-01-23 | Univ Utah Res Found | Kolon-tumor-spezifische bindungspeptide |
WO2005084168A2 (en) * | 2003-09-08 | 2005-09-15 | Proportional Technologies, Inc. | MINIATURIZED 62Zn/62Cu GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62Cu KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED Cu-BIS(THIOSEMICARBAZONE) COMPOUNDS |
DE102004005280B4 (de) * | 2004-01-29 | 2007-02-22 | Rotop Pharmaka Gmbh | Verfahren und pharmazeutischer Kit zur Herstellung von Rhenium-188 markierten Mikrosphären |
WO2006009894A1 (en) * | 2004-06-17 | 2006-01-26 | Anazaohealth Corporation | Stabilized and lyophilized radiopharmaceutical agents for destroying tumors |
WO2006009891A1 (en) * | 2004-06-17 | 2006-01-26 | Anazaohealth Corporation | A method of treatment of patients using stabilized and lyophilized radiopharmaceutical agents |
WO2006085941A1 (en) * | 2004-06-17 | 2006-08-17 | Anazaohealth Corporation | Copper-complex isonitrile positron emission tomography (pet) imaging agent and method |
US7229603B2 (en) * | 2004-06-17 | 2007-06-12 | Anazaohealth Corporation | Stablilized and lyophilized radiopharmaceutical agents |
KR20140001257A (ko) | 2008-05-13 | 2014-01-06 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(map) 태그 및 관련된 방법 |
BRPI1003965B1 (pt) * | 2010-10-29 | 2020-07-28 | Universidade Federal Do Rio De Janeiro Ufrj | Processo de marcação com radionuclídeos de análogos da somatostatina associados à doenças cuja fisiopatogenia envolva receptores de somatostatina, reagente para diagnóstico "in vivo" e/ou "in vitro" a base de análogos da -5 somatostatina associados a radionuclídeos, método de diagnóstico "in vitro" e/ou "in vivo" de doenças cuja fisiopatogenia envolva receptores de somatostatina utilizando o reagente assim obtido e kit para diagnóstico de doenças cuja fisiopatogenia envolva receptores de somatostatina a base do referido reagente |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
KR20150140650A (ko) * | 2013-02-15 | 2015-12-16 | 토마스 제퍼슨 유니버시티 | 종양 이미지를 위한 키트 |
AU2017354941B2 (en) * | 2016-11-04 | 2021-02-11 | Clarity Pharmaceuticals Ltd | Formulations for radiotherapy and diagnostic imaging |
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US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
US4668503A (en) * | 1982-07-26 | 1987-05-26 | Trustees Of University Of Massachusetts | Process for labeling amines with 99m Tc |
US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
US4612302A (en) * | 1983-11-14 | 1986-09-16 | Brigham And Women's Hospital | Clinical use of somatostatin analogues |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
US4904642A (en) * | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
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US5092885A (en) * | 1987-02-12 | 1992-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Peptides with laminin activity |
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DE4229238C2 (de) * | 1991-09-24 | 1996-04-18 | Pwh Anlagen & Systeme Gmbh | Antriebs- und Führungseinrichtung für einen Stetigförderer |
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-
1996
- 1996-05-21 US US08/651,179 patent/US5985240A/en not_active Expired - Fee Related
- 1996-05-22 CA CA002219492A patent/CA2219492A1/en not_active Abandoned
- 1996-05-22 AU AU59264/96A patent/AU5926496A/en not_active Abandoned
- 1996-05-22 AT AT96916556T patent/ATE315411T1/de not_active IP Right Cessation
- 1996-05-22 JP JP08535851A patent/JP2000515847A/ja active Pending
- 1996-05-22 DE DE69635732T patent/DE69635732T2/de not_active Expired - Fee Related
- 1996-05-22 WO PCT/US1996/007480 patent/WO1996037239A1/en active IP Right Grant
- 1996-05-22 EP EP96916556A patent/EP0827412B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69635732D1 (de) | 2006-04-06 |
EP0827412B1 (de) | 2006-01-11 |
DE69635732T2 (de) | 2006-11-02 |
EP0827412A1 (de) | 1998-03-11 |
JP2000515847A (ja) | 2000-11-28 |
WO1996037239A1 (en) | 1996-11-28 |
EP0827412A4 (de) | 2002-08-07 |
US5985240A (en) | 1999-11-16 |
CA2219492A1 (en) | 1996-11-28 |
AU5926496A (en) | 1996-12-11 |
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