ATE314862T1 - Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze - Google Patents

Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze

Info

Publication number
ATE314862T1
ATE314862T1 AT01929595T AT01929595T ATE314862T1 AT E314862 T1 ATE314862 T1 AT E314862T1 AT 01929595 T AT01929595 T AT 01929595T AT 01929595 T AT01929595 T AT 01929595T AT E314862 T1 ATE314862 T1 AT E314862T1
Authority
AT
Austria
Prior art keywords
subcutane
salts
gel
pharmaceutical composition
use containing
Prior art date
Application number
AT01929595T
Other languages
English (en)
Inventor
Rainer Bader
Petra Bastian
Achim Goepferich
Wolfgang Roedel
Gerhard Winter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE314862T1 publication Critical patent/ATE314862T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT01929595T 2000-05-05 2001-04-23 Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze ATE314862T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10021917 2000-05-05

Publications (1)

Publication Number Publication Date
ATE314862T1 true ATE314862T1 (de) 2006-02-15

Family

ID=7640900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01929595T ATE314862T1 (de) 2000-05-05 2001-04-23 Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze

Country Status (16)

Country Link
US (1) US6676970B2 (de)
EP (1) EP1284754B1 (de)
JP (1) JP3923800B2 (de)
KR (1) KR100492110B1 (de)
CN (1) CN1180846C (de)
AR (2) AR033671A1 (de)
AT (1) ATE314862T1 (de)
AU (1) AU778431B2 (de)
BR (1) BR0110618A (de)
CA (1) CA2407747C (de)
DE (1) DE60116483T2 (de)
DK (1) DK1284754T3 (de)
ES (1) ES2254410T3 (de)
MX (1) MXPA02010740A (de)
WO (1) WO2001085217A1 (de)
ZA (1) ZA200208499B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151876A1 (en) * 2001-02-07 2002-10-17 Tai-Wah Chan Devices and methods for management of bone density
US7875597B2 (en) * 2002-07-24 2011-01-25 New York University Treatment of spinal mechanical pain
CN100364544C (zh) * 2004-07-21 2008-01-30 上海第二医科大学附属瑞金医院 一种携带二氯亚甲基二膦酸的明胶微粒及制备方法
EP1713489B1 (de) * 2004-08-23 2011-01-19 Teva Pharmaceutical Industries Ltd Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
US7294195B2 (en) * 2005-08-08 2007-11-13 Wacker Chemical Corporation Water repellant gypsum compositions
ITMI20052515A1 (it) * 2005-12-29 2007-06-30 Abiogen Pharma Spa Formulazione farmaceutica per il trattamento della osteoartrite
EP1923049A1 (de) * 2006-11-17 2008-05-21 Besins Healthcare Pharmazeutische Zusammensetzungen mit einer Bisphosphonatverbindung
EP2114368A1 (de) * 2006-11-17 2009-11-11 Besins Healthcare Pharmazeutische zusammensetzungen mit einer bisphosphonat-verbindung
US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
EP1992364A1 (de) * 2007-05-16 2008-11-19 Biosuma S.r.l. Phosphierte oder bisphosphonierte und optional vernetzte Derivate carboxylierter Polysaccharide sowie ihre Herstellung und ihre biomedizinischen Verwendungen
WO2009128918A1 (en) * 2008-04-14 2009-10-22 Halozyme, Inc. Combination therapy using a soluble hyaluronidase and a bisphosphonate
US20100247607A1 (en) * 2009-03-26 2010-09-30 Psivida Us, Inc. Implantable formulations of bisphosphonic acids
ES2650665T3 (es) * 2009-07-31 2018-01-19 Grünenthal GmbH Método de cristalización y biodisponibilidad
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
CN102000094B (zh) * 2010-09-27 2013-03-27 天津南开允公医药科技有限公司 一种含有伊班膦酸的药物组合物及制备工艺
WO2012048285A1 (en) * 2010-10-08 2012-04-12 Lanco Biosciences, Inc. Delivery of bisphosphonates by microinjection systems
WO2012071517A2 (en) 2010-11-24 2012-05-31 Thar Pharmaceuticals, Inc. Novel crystalline forms
GB201412236D0 (en) * 2014-07-09 2014-08-20 Univ Nottingham Method of producing and using alginate hydrogels
EP3189852B1 (de) * 2014-09-03 2021-04-07 Nitto Denko Corporation Bisphosphonathaltige pharmazeutische impfstoffzusammensetzung für humorale immunität
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis
IT201800009444A1 (it) 2018-10-15 2020-04-15 Fidia Farm Spa Coniugati tra acido ialuronico e amminobisfosfonati e loro impiego terapeutico

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE61111C (de) B. WINKLER in Berka a. Werrä Verfahren zur Herstellung von Knöpfen ohne Fadenbefestigung
US4446052A (en) * 1982-05-17 1984-05-01 The Procter & Gamble Company Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3540150A1 (de) 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3640938A1 (de) 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922077A (en) 1989-01-31 1990-05-01 Raytheon Company Method of laser marking metal packages
CA2035179C (en) * 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4228552A1 (de) * 1992-08-27 1994-03-03 Boehringer Mannheim Gmbh Diphosphonsäuren und deren Salze enthaltende Arzneimittel
DE4244423A1 (de) 1992-12-29 1994-06-30 Boehringer Mannheim Gmbh Wasserlösliche Calciumsalze der 1-Hydroxy-3-(methylpentylamino)propan-1,1-bisphosphonsäure, ihre Herstellung und Verwendung als Arzneimittel
DE4244422A1 (de) 1992-12-29 1994-06-30 Boehringer Mannheim Gmbh Schwerlösliche Zink- und Magnesiumsalze von 1,1-Bisphosphonsäuren, ihre Herstellung und Verwendung als Arzneimittel
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
US5994329A (en) * 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation

Also Published As

Publication number Publication date
AU778431B2 (en) 2004-12-02
BR0110618A (pt) 2003-04-29
CN1427727A (zh) 2003-07-02
AR055407A2 (es) 2007-08-22
ZA200208499B (en) 2004-02-26
CN1180846C (zh) 2004-12-22
JP3923800B2 (ja) 2007-06-06
CA2407747A1 (en) 2001-11-15
EP1284754B1 (de) 2006-01-04
KR20030009470A (ko) 2003-01-29
AR033671A1 (es) 2004-01-07
CA2407747C (en) 2008-03-11
ES2254410T3 (es) 2006-06-16
JP2003532689A (ja) 2003-11-05
KR100492110B1 (ko) 2005-06-02
DE60116483D1 (de) 2006-03-30
AU5631701A (en) 2001-11-20
MXPA02010740A (es) 2003-03-10
EP1284754A1 (de) 2003-02-26
DE60116483T2 (de) 2006-09-07
US20010053388A1 (en) 2001-12-20
DK1284754T3 (da) 2006-05-01
US6676970B2 (en) 2004-01-13
WO2001085217A1 (en) 2001-11-15

Similar Documents

Publication Publication Date Title
ATE314862T1 (de) Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze
NO20003219D0 (no) Oralfarmasøytisk doseringsform med pulsert frigivningsvirkning
DE60138495D1 (de) Pharmazeutische Zusammensetzung Trehalose zur ophthalmischen Verwendung enthaltend
DE69924710D1 (de) Pharmazeutische zubereitung zur anwendung in der antiasthmatherapie
ATE312602T1 (de) Orale pharmazeutische dosierungsform mit verlängerter wirkstofffreisetzung
DE69613463D1 (de) Filmbildende pharmazeutische zusammensetzungen zur transdermalen verabreichung
ATE404207T1 (de) Orale pharmazeutische zubereitung enthaltend ibandronat
DE60224111D1 (de) Bausatz zur Herstellung einer Verabreichungsform zur Abgabe einer bioaktiven Substanz
DE60106623D1 (de) Neue pharmazeutische zusammensetzung
BR9607422A (pt) Composiçoes farmacêuticas paranterais contendo sais de alquilamônio de ácido 2-arilpropiônicos
DE69924999D1 (de) Lipasehemmer enthaltende pharmazeutische zusammensetzungen
DE60013445D1 (de) Pharmazeutische dosierungsformen zur kontrollierter pulsierender abgabe
BR9710289A (pt) Composi-Æo farmac-utica contendo sal cido de adi-Æo de medicamento b sico
DE69621885D1 (de) Neue galenische orale pharmazeutische formulierung
ATE449079T1 (de) Pharmazeutische zusammensetzungen beinhaltend kristallsalze von 7-ä4-(4-fluorophenyl)-6- isopropyl-2-
DE50206657D1 (de) Pharmazeutische zusammensetzung zur behandlung von multiple sklerose
ATA1292000A (de) Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
DE60010456D1 (de) Pharmazeutische oder diätetische zusammensetzung zur prävention oder behandlung von hyperoxalurie
ATE487471T1 (de) Therapeutische formulierung zur verabreichung von tolterodin mit kontrollierter freisetzung
DE60123381D1 (de) Neue dosisformen von substituierten benzimidazolen und verfahren zur deren verwendung
DE50107506D1 (de) Phosphonsäuren enthaltendes dentalmaterial
ATE324882T1 (de) In der mundhöhle dispergierbare pharmazeutische zusammensetzung mit agomelatin
DE69118081D1 (de) Hyaluronsäurenatriumsalz und Desinfektionsmittel enthaltende pharmazeutische Zusammensetzungen zur äusserlichen Anwendung
FI970834A (fi) Kynämäisessä lääkeinjektioruiskussa käytettäväksi tarkoitettu patruunakokoonpano
ATA59499A (de) Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1284754

Country of ref document: EP