ATE313526T1 - Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung - Google Patents

Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung

Info

Publication number
ATE313526T1
ATE313526T1 AT99952654T AT99952654T ATE313526T1 AT E313526 T1 ATE313526 T1 AT E313526T1 AT 99952654 T AT99952654 T AT 99952654T AT 99952654 T AT99952654 T AT 99952654T AT E313526 T1 ATE313526 T1 AT E313526T1
Authority
AT
Austria
Prior art keywords
amlodipine
synthesis
production process
corresponding application
intermediate stage
Prior art date
Application number
AT99952654T
Other languages
English (en)
Inventor
Laura Coppi
Guillen Yolanda Gasanz
Pardo Julio Campon
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Application granted granted Critical
Publication of ATE313526T1 publication Critical patent/ATE313526T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT99952654T 1998-10-26 1999-10-18 Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung ATE313526T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802240A ES2151850B1 (es) 1998-10-26 1998-10-26 Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
PCT/ES1999/000333 WO2000024714A1 (es) 1998-10-26 1999-10-18 Intermedio para la sintesis de amlodipino, procedimiento para su obtencion y utilizacion correspondiente

Publications (1)

Publication Number Publication Date
ATE313526T1 true ATE313526T1 (de) 2006-01-15

Family

ID=8305582

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99952654T ATE313526T1 (de) 1998-10-26 1999-10-18 Zwischenstufe für die synthese von amlodipin, herstellungsverfahren und entsprechende anwendung

Country Status (12)

Country Link
US (1) US6603006B2 (de)
EP (1) EP1125924B1 (de)
JP (1) JP2002528436A (de)
KR (1) KR100576166B1 (de)
AT (1) ATE313526T1 (de)
AU (1) AU752042B2 (de)
CA (1) CA2349013C (de)
DE (1) DE69929079T2 (de)
DK (1) DK1125924T3 (de)
ES (2) ES2151850B1 (de)
SI (1) SI1125924T1 (de)
WO (1) WO2000024714A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
WO2002053539A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amlodipine hemimaleate
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
CA2433181C (en) 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
BR0116557A (pt) 2000-12-29 2003-10-28 Pfizer Ltd Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina
BR0116554A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
CA2433284A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
ES2211317B1 (es) * 2002-11-18 2005-10-16 Finaf 92, S.A. Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
DK1601653T3 (da) * 2003-03-07 2009-03-30 Syngenta Participations Ag Fremgangsmåde til fremstilling af substituerede nikotinsyreestre
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
JP2010100562A (ja) * 2008-10-23 2010-05-06 Daito Kk アムロジピン製造中間体の精製方法
EP4403199A2 (de) 2015-08-14 2024-07-24 ResMed Pty Ltd Überwachung einer atemdrucktherapie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PT77842B (en) * 1982-12-21 1986-05-05 Pfizer Process for preparing dihydropyridines
GB8422139D0 (en) * 1984-09-01 1984-10-03 Fisons Plc Biologically active nitrogen heterocyclics
AU7810087A (en) * 1986-08-14 1988-03-08 Byk Gulden Lomberg Chemische Fabrik Gmbh New piperidines
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Also Published As

Publication number Publication date
DK1125924T3 (da) 2006-05-08
WO2000024714A1 (es) 2000-05-04
US20020068831A1 (en) 2002-06-06
ES2251843T3 (es) 2006-05-01
SI1125924T1 (sl) 2006-04-30
JP2002528436A (ja) 2002-09-03
AU6477299A (en) 2000-05-15
CA2349013A1 (en) 2000-05-04
KR20010093781A (ko) 2001-10-29
EP1125924B1 (de) 2005-12-21
CA2349013C (en) 2007-10-02
KR100576166B1 (ko) 2006-05-03
DE69929079D1 (de) 2006-01-26
AU752042B2 (en) 2002-09-05
ES2151850B1 (es) 2001-08-16
DE69929079T2 (de) 2006-06-22
EP1125924A1 (de) 2001-08-22
US6603006B2 (en) 2003-08-05
ES2151850A1 (es) 2001-01-01

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