SI1125924T1 - Intermediat za sintezo amlodipina, postopek za pripravo in ustrezna uporaba - Google Patents

Intermediat za sintezo amlodipina, postopek za pripravo in ustrezna uporaba

Info

Publication number
SI1125924T1
SI1125924T1 SI9930870T SI9930870T SI1125924T1 SI 1125924 T1 SI1125924 T1 SI 1125924T1 SI 9930870 T SI9930870 T SI 9930870T SI 9930870 T SI9930870 T SI 9930870T SI 1125924 T1 SI1125924 T1 SI 1125924T1
Authority
SI
Slovenia
Prior art keywords
amlodipine
synthesis
preparation process
preparation
chem
Prior art date
Application number
SI9930870T
Other languages
English (en)
Inventor
Laura Coppi
Guillen Yolanda Gasanz
Pardo Julio Campon
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Publication of SI1125924T1 publication Critical patent/SI1125924T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
SI9930870T 1998-10-26 1999-10-18 Intermediat za sintezo amlodipina, postopek za pripravo in ustrezna uporaba SI1125924T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802240A ES2151850B1 (es) 1998-10-26 1998-10-26 Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
PCT/ES1999/000333 WO2000024714A1 (es) 1998-10-26 1999-10-18 Intermedio para la sintesis de amlodipino, procedimiento para su obtencion y utilizacion correspondiente

Publications (1)

Publication Number Publication Date
SI1125924T1 true SI1125924T1 (sl) 2006-04-30

Family

ID=8305582

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930870T SI1125924T1 (sl) 1998-10-26 1999-10-18 Intermediat za sintezo amlodipina, postopek za pripravo in ustrezna uporaba

Country Status (12)

Country Link
US (1) US6603006B2 (sl)
EP (1) EP1125924B1 (sl)
JP (1) JP2002528436A (sl)
KR (1) KR100576166B1 (sl)
AT (1) ATE313526T1 (sl)
AU (1) AU752042B2 (sl)
CA (1) CA2349013C (sl)
DE (1) DE69929079T2 (sl)
DK (1) DK1125924T3 (sl)
ES (2) ES2151850B1 (sl)
SI (1) SI1125924T1 (sl)
WO (1) WO2000024714A1 (sl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
CA2433181C (en) 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
MXPA03005886A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado de aspartato de amlodipina como antagonista del canal de calcio.
BR0116554A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
MXPA03005884A (es) 2000-12-29 2005-04-08 Pfizer Ltd Hemimaleato de amlodipina.
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
WO2002054062A2 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
SI1309555T1 (sl) 2000-12-29 2005-12-31 Pfizer Ltd Postopek izdelave amlodipin-maleata
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
ES2211317B1 (es) * 2002-11-18 2005-10-16 Finaf 92, S.A. Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
PT1601653E (pt) * 2003-03-07 2009-04-27 Syngenta Participations Ag Processo para a produção de ésteres de ácido nicotínico substituído
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
JP2010100562A (ja) * 2008-10-23 2010-05-06 Daito Kk アムロジピン製造中間体の精製方法
US10751490B2 (en) 2015-08-14 2020-08-25 ResMed Pty Ltd Monitoring respiratory pressure therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
GB8422139D0 (en) * 1984-09-01 1984-10-03 Fisons Plc Biologically active nitrogen heterocyclics
WO1988001266A1 (en) * 1986-08-14 1988-02-25 Byk Gulden Lomberg Chemische Fabrik Gmbh New piperidines
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Also Published As

Publication number Publication date
KR100576166B1 (ko) 2006-05-03
US6603006B2 (en) 2003-08-05
DK1125924T3 (da) 2006-05-08
ATE313526T1 (de) 2006-01-15
CA2349013A1 (en) 2000-05-04
DE69929079D1 (de) 2006-01-26
AU752042B2 (en) 2002-09-05
EP1125924A1 (en) 2001-08-22
JP2002528436A (ja) 2002-09-03
KR20010093781A (ko) 2001-10-29
US20020068831A1 (en) 2002-06-06
ES2251843T3 (es) 2006-05-01
AU6477299A (en) 2000-05-15
DE69929079T2 (de) 2006-06-22
ES2151850B1 (es) 2001-08-16
WO2000024714A1 (es) 2000-05-04
CA2349013C (en) 2007-10-02
ES2151850A1 (es) 2001-01-01
EP1125924B1 (en) 2005-12-21

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