DK1125924T3 - Mellemprodukt til syntesen af amlodipin, fremstillingsfremgangsmåde og tilsvarende anvendelse - Google Patents

Mellemprodukt til syntesen af amlodipin, fremstillingsfremgangsmåde og tilsvarende anvendelse

Info

Publication number
DK1125924T3
DK1125924T3 DK99952654T DK99952654T DK1125924T3 DK 1125924 T3 DK1125924 T3 DK 1125924T3 DK 99952654 T DK99952654 T DK 99952654T DK 99952654 T DK99952654 T DK 99952654T DK 1125924 T3 DK1125924 T3 DK 1125924T3
Authority
DK
Denmark
Prior art keywords
preparation
amlodipine
synthesis
corresponding use
chem
Prior art date
Application number
DK99952654T
Other languages
Danish (da)
English (en)
Inventor
Guillen Yolanda Gasanz
Laura Coppi
Pardo Julio Campon
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Application granted granted Critical
Publication of DK1125924T3 publication Critical patent/DK1125924T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK99952654T 1998-10-26 1999-10-18 Mellemprodukt til syntesen af amlodipin, fremstillingsfremgangsmåde og tilsvarende anvendelse DK1125924T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802240A ES2151850B1 (es) 1998-10-26 1998-10-26 Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.

Publications (1)

Publication Number Publication Date
DK1125924T3 true DK1125924T3 (da) 2006-05-08

Family

ID=8305582

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99952654T DK1125924T3 (da) 1998-10-26 1999-10-18 Mellemprodukt til syntesen af amlodipin, fremstillingsfremgangsmåde og tilsvarende anvendelse

Country Status (12)

Country Link
US (1) US6603006B2 (de)
EP (1) EP1125924B1 (de)
JP (1) JP2002528436A (de)
KR (1) KR100576166B1 (de)
AT (1) ATE313526T1 (de)
AU (1) AU752042B2 (de)
CA (1) CA2349013C (de)
DE (1) DE69929079T2 (de)
DK (1) DK1125924T3 (de)
ES (2) ES2151850B1 (de)
SI (1) SI1125924T1 (de)
WO (1) WO2000024714A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
EP1346214A2 (de) 2000-12-29 2003-09-24 Pfizer Limited Referenzstandards und verfahren zur bestimmung der reinheit oder stabilität von amlodipin-maleat
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
EP1309556B1 (de) 2000-12-29 2004-11-24 Pfizer Limited Amlodipinfumarat
WO2002053541A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
WO2002053542A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Process for making amlodipine maleate
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
ES2254495T4 (es) 2000-12-29 2007-06-16 Pfizer Limited Hemimaleato de amlodipina.
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
ES2211317B1 (es) * 2002-11-18 2005-10-16 Finaf 92, S.A. Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
JP4673293B2 (ja) * 2003-03-07 2011-04-20 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 置換されたニコチン酸エステルの製造方法
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
JP2010100562A (ja) * 2008-10-23 2010-05-06 Daito Kk アムロジピン製造中間体の精製方法
WO2017027906A1 (en) 2015-08-14 2017-02-23 Resmed Limited Monitoring respiratory pressure therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
GB8422139D0 (en) * 1984-09-01 1984-10-03 Fisons Plc Biologically active nitrogen heterocyclics
AU7810087A (en) * 1986-08-14 1988-03-08 Byk Gulden Lomberg Chemische Fabrik Gmbh New piperidines
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Also Published As

Publication number Publication date
AU6477299A (en) 2000-05-15
EP1125924A1 (de) 2001-08-22
AU752042B2 (en) 2002-09-05
ES2151850A1 (es) 2001-01-01
ATE313526T1 (de) 2006-01-15
DE69929079D1 (de) 2006-01-26
DE69929079T2 (de) 2006-06-22
KR100576166B1 (ko) 2006-05-03
CA2349013A1 (en) 2000-05-04
KR20010093781A (ko) 2001-10-29
JP2002528436A (ja) 2002-09-03
CA2349013C (en) 2007-10-02
SI1125924T1 (sl) 2006-04-30
US20020068831A1 (en) 2002-06-06
WO2000024714A1 (es) 2000-05-04
ES2251843T3 (es) 2006-05-01
ES2151850B1 (es) 2001-08-16
EP1125924B1 (de) 2005-12-21
US6603006B2 (en) 2003-08-05

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