ATE312946T1 - Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten - Google Patents

Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten

Info

Publication number
ATE312946T1
ATE312946T1 AT02004954T AT02004954T ATE312946T1 AT E312946 T1 ATE312946 T1 AT E312946T1 AT 02004954 T AT02004954 T AT 02004954T AT 02004954 T AT02004954 T AT 02004954T AT E312946 T1 ATE312946 T1 AT E312946T1
Authority
AT
Austria
Prior art keywords
determining
amount
free floating
dna
floating dna
Prior art date
Application number
AT02004954T
Other languages
English (en)
Inventor
Kurt Berlin
Andrzej Sledziewski
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Application granted granted Critical
Publication of ATE312946T1 publication Critical patent/ATE312946T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT02004954T 2002-03-05 2002-03-05 Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten ATE312946T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02004954A EP1342794B1 (de) 2002-03-05 2002-03-05 Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten

Publications (1)

Publication Number Publication Date
ATE312946T1 true ATE312946T1 (de) 2005-12-15

Family

ID=27741132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02004954T ATE312946T1 (de) 2002-03-05 2002-03-05 Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten

Country Status (10)

Country Link
US (1) US20050221314A1 (de)
EP (2) EP1342794B1 (de)
JP (1) JP4727149B2 (de)
AT (1) ATE312946T1 (de)
AU (1) AU2003218691B2 (de)
CA (1) CA2478493A1 (de)
DE (1) DE60207979T2 (de)
DK (1) DK1342794T3 (de)
ES (1) ES2253461T3 (de)
WO (1) WO2003074730A1 (de)

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IL299444A (en) 2012-09-20 2023-02-01 Univ Hong Kong Chinese Non-invasive determination of fetal or tumor methylation from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
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EP3039161B1 (de) 2013-08-30 2021-10-06 Personalis, Inc. Verfahren und system zur genomanalyse
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GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
EP3524694B1 (de) 2013-12-28 2020-07-15 Guardant Health, Inc. Verfahren und systeme für den nachweis genetischer varianten
WO2015159293A2 (en) * 2014-04-14 2015-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. A method and kit for determining the tissue or cell origin of dna
ES2741400T3 (es) * 2014-07-18 2020-02-10 Univ Hong Kong Chinese Análisis de patrones de metilación de tejidos en mezcla de ADN
EP3212808B1 (de) 2014-10-30 2022-03-02 Personalis, Inc. Verfahren zur verwendung von mosaizismus in nukleinsäuren, die distal zu ihrem ursprung entnommen wurden
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
CN115881230A (zh) * 2015-12-17 2023-03-31 伊路敏纳公司 区分复杂生物样品中的甲基化水平
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
EP3885447B1 (de) 2016-05-30 2024-01-10 The Chinese University Of Hong Kong Erkennung von hämatologischen erkrankungen unter verwendung von zellfreier dna im blut
CN116445593A (zh) 2016-08-10 2023-07-18 格里尔公司 测定一生物样品的一甲基化图谱的方法
CA3126055A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
TWI797095B (zh) 2016-10-24 2023-04-01 美商格瑞爾有限責任公司 腫瘤檢測之方法及系統
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
US10633713B2 (en) 2017-01-25 2020-04-28 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
EP3366780B1 (de) 2017-02-23 2020-05-06 Siemens Healthcare GmbH Sequenzanalyse von einzelmolekülen und hochempfindliche methylierungsanalyse zur gewebespezifischen analyse
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
EP3856903A4 (de) 2018-09-27 2022-07-27 Grail, LLC Methylierungsmarker und gezieltes methylierungssondenpaneel
EP3918089A1 (de) 2019-01-31 2021-12-08 Guardant Health, Inc. Zusammensetzungen und verfahren zur isolierung zellfreier dna
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
CN118215845A (zh) 2021-09-13 2024-06-18 普罗科技有限公司 增强的对生物分子的检测和定量

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Also Published As

Publication number Publication date
WO2003074730A1 (en) 2003-09-12
EP1483410A1 (de) 2004-12-08
AU2003218691A1 (en) 2003-09-16
DE60207979T2 (de) 2006-09-28
CA2478493A1 (en) 2003-09-12
DK1342794T3 (da) 2006-04-24
AU2003218691B2 (en) 2008-06-12
EP1342794B1 (de) 2005-12-14
JP2005518809A (ja) 2005-06-30
US20050221314A1 (en) 2005-10-06
ES2253461T3 (es) 2006-06-01
JP4727149B2 (ja) 2011-07-20
EP1342794A1 (de) 2003-09-10
DE60207979D1 (de) 2006-01-19

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