DE60207979D1 - Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten - Google Patents

Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten

Info

Publication number
DE60207979D1
DE60207979D1 DE60207979T DE60207979T DE60207979D1 DE 60207979 D1 DE60207979 D1 DE 60207979D1 DE 60207979 T DE60207979 T DE 60207979T DE 60207979 T DE60207979 T DE 60207979T DE 60207979 D1 DE60207979 D1 DE 60207979D1
Authority
DE
Germany
Prior art keywords
amount
free floating
dna
body fluids
floating dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60207979T
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English (en)
Other versions
DE60207979T2 (de
Inventor
Kurt Berlin
Andrzej Sledziewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
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Epigenomics AG
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Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of DE60207979D1 publication Critical patent/DE60207979D1/de
Application granted granted Critical
Publication of DE60207979T2 publication Critical patent/DE60207979T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60207979T 2002-03-05 2002-03-05 Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten Expired - Lifetime DE60207979T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02004954A EP1342794B1 (de) 2002-03-05 2002-03-05 Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten

Publications (2)

Publication Number Publication Date
DE60207979D1 true DE60207979D1 (de) 2006-01-19
DE60207979T2 DE60207979T2 (de) 2006-09-28

Family

ID=27741132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60207979T Expired - Lifetime DE60207979T2 (de) 2002-03-05 2002-03-05 Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten

Country Status (10)

Country Link
US (1) US20050221314A1 (de)
EP (2) EP1342794B1 (de)
JP (1) JP4727149B2 (de)
AT (1) ATE312946T1 (de)
AU (1) AU2003218691B2 (de)
CA (1) CA2478493A1 (de)
DE (1) DE60207979T2 (de)
DK (1) DK1342794T3 (de)
ES (1) ES2253461T3 (de)
WO (1) WO2003074730A1 (de)

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US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2014039556A1 (en) 2012-09-04 2014-03-13 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
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EP3087204B1 (de) 2013-12-28 2018-02-14 Guardant Health, Inc. Verfahren und systeme für den nachweis genetischer varianten
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EP3169813B1 (de) 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylierungsmusteranalyse von gewebe in einem dna-gemisch
EP4026913A1 (de) 2014-10-30 2022-07-13 Personalis, Inc. Verfahren zur verwendung von mosaizismus in nukleinsäuren, die distal zu ihrem ursprung entnommen wurden
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
AU2016370835B2 (en) * 2015-12-17 2020-02-13 Illumina, Inc. Distinguishing methylation levels in complex biological samples
EP3390668A4 (de) 2015-12-17 2020-04-01 Guardant Health, Inc. Verfahren zur bestimmung der tumorgenkopienzahl durch analyse von zellfreier dna
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10781490B2 (en) 2016-05-30 2020-09-22 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
CN116445593A (zh) 2016-08-10 2023-07-18 格里尔公司 测定一生物样品的一甲基化图谱的方法
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
AU2017336153B2 (en) 2016-09-30 2023-07-13 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3535415A4 (de) 2016-10-24 2020-07-01 The Chinese University of Hong Kong Verfahren und systeme zur tumordetektion
IL315032A (en) 2016-11-30 2024-10-01 The Chinese Univ Of Hong Kong Analysis of cell-free DNA in urine and other samples
TWI803477B (zh) 2017-01-25 2023-06-01 香港中文大學 使用核酸片段之診斷應用
EP3366780B1 (de) 2017-02-23 2020-05-06 Siemens Healthcare GmbH Sequenzanalyse von einzelmolekülen und hochempfindliche methylierungsanalyse zur gewebespezifischen analyse
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
AU2019234843A1 (en) 2018-03-13 2020-09-24 Grail, Llc Anomalous fragment detection and classification
WO2019195268A2 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
WO2020069350A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
CN113661249A (zh) 2019-01-31 2021-11-16 夸登特健康公司 用于分离无细胞dna的组合物和方法
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
WO2021154893A1 (en) 2020-01-30 2021-08-05 Prognomiq Inc Lung biomarkers and methods of use thereof
EP4347886A1 (de) 2021-06-03 2024-04-10 Inherent Biosciences, Inc. Dna-methylierungsanalyse zur identifizierung des zelltyps
EP4402473A1 (de) 2021-09-13 2024-07-24 Prognomiq Inc Verbesserter nachweis und quantifizierung von biomolekülen
CN116042848B (zh) * 2021-10-28 2024-08-09 北京干细胞与再生医学研究院 一种通过血样检测判断动物体内存在移植物的方法

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Also Published As

Publication number Publication date
ES2253461T3 (es) 2006-06-01
DK1342794T3 (da) 2006-04-24
EP1483410A1 (de) 2004-12-08
DE60207979T2 (de) 2006-09-28
US20050221314A1 (en) 2005-10-06
WO2003074730A1 (en) 2003-09-12
AU2003218691B2 (en) 2008-06-12
CA2478493A1 (en) 2003-09-12
JP4727149B2 (ja) 2011-07-20
EP1342794B1 (de) 2005-12-14
ATE312946T1 (de) 2005-12-15
EP1342794A1 (de) 2003-09-10
AU2003218691A1 (en) 2003-09-16
JP2005518809A (ja) 2005-06-30

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