ATE311463T1 - Fusionsprotein mit multiplen epitopen - Google Patents

Fusionsprotein mit multiplen epitopen

Info

Publication number
ATE311463T1
ATE311463T1 AT97927767T AT97927767T ATE311463T1 AT E311463 T1 ATE311463 T1 AT E311463T1 AT 97927767 T AT97927767 T AT 97927767T AT 97927767 T AT97927767 T AT 97927767T AT E311463 T1 ATE311463 T1 AT E311463T1
Authority
AT
Austria
Prior art keywords
epitopes
epitope
amino acid
acid sequence
sequences
Prior art date
Application number
AT97927767T
Other languages
German (de)
English (en)
Inventor
Pablo D T Valenzuela
David Ying Chien
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/653,226 external-priority patent/US6514731B1/en
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE311463T1 publication Critical patent/ATE311463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97927767T 1996-05-24 1997-05-23 Fusionsprotein mit multiplen epitopen ATE311463T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/653,226 US6514731B1 (en) 1996-05-24 1996-05-24 Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US08/859,524 US6428792B1 (en) 1996-05-24 1997-05-20 Hepatitis C virus multiple copy epitope fusion antigens
PCT/US1997/008950 WO1997044469A2 (en) 1996-05-24 1997-05-23 Multiple epitope fusion protein

Publications (1)

Publication Number Publication Date
ATE311463T1 true ATE311463T1 (de) 2005-12-15

Family

ID=27096474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97927767T ATE311463T1 (de) 1996-05-24 1997-05-23 Fusionsprotein mit multiplen epitopen

Country Status (11)

Country Link
EP (1) EP0935662B1 (enExample)
JP (2) JP3945822B2 (enExample)
AT (1) ATE311463T1 (enExample)
AU (1) AU719929B2 (enExample)
CA (1) CA2250723C (enExample)
DE (1) DE69734776T2 (enExample)
DK (1) DK0935662T3 (enExample)
ES (1) ES2251028T3 (enExample)
IL (1) IL126460A (enExample)
NZ (1) NZ333431A (enExample)
WO (1) WO1997044469A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6322965B1 (en) * 1997-02-10 2001-11-27 Advanced Life Science Institute, Inc. Chimera antigen peptide
US6261764B1 (en) 1997-09-22 2001-07-17 Chiron Corporation Buffers for stabilizing antigens
CA2303123C (en) * 1997-09-22 2006-04-11 Chiron Corporation Method for detecting antibodies in a sample
IL137458A0 (en) * 1998-01-30 2001-07-24 Gen Hospital Corp Genetic immunization with nonstructural proteins of hepatitis c virus
ATE401340T1 (de) 1998-04-17 2008-08-15 Innogenetics Nv Verfahren zur verbesserung der proteinkonformation mit hilfe von reduktionsmitteln
AU3714499A (en) * 1998-05-14 1999-11-29 Pasteur Merieux Serums Et Vaccins Hepatitis c virus mimotopes
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6379903B1 (en) 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
JP2003512826A (ja) 1999-10-27 2003-04-08 カイロン コーポレイション Ｈｃｖ特異的ｔ細胞の活性化
ATE366582T1 (de) * 1999-12-28 2007-08-15 Pharmexa Inc Optimierte minigene und dadurch kodierte peptide
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
ES2288969T3 (es) * 2000-06-15 2008-02-01 Novartis Vaccines And Diagnostics, Inc. Inmunoensayos para anticuerpos anti-hcv.
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
MXPA05002641A (es) 2002-09-09 2005-05-05 Chiron Corp Ensayo del virus de la hepatitis c.
EP1576125A4 (en) * 2002-10-25 2008-09-03 Novartis Vaccines & Diagnostic ACTIVATION OF SPECIFIC HCV LYMPHOCYTES
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
ES2377978T3 (es) 2004-08-27 2012-04-03 Novartis Vaccines And Diagnostics, Inc. Mutantes de proteínas no estructurales de VHC y usos de los mismos
JP5475279B2 (ja) * 2005-06-17 2014-04-16 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ Ｃ型肝炎ウイルス核酸ワクチン
EP1969001A2 (en) 2005-11-22 2008-09-17 Novartis Vaccines and Diagnostics, Inc. Norovirus and sapovirus antigens
AU2008335457B2 (en) 2007-12-07 2015-04-16 Glaxosmithkline Biologicals S.A. Compositions for inducing immune responses
CN103282375B (zh) 2010-12-02 2017-01-11 比奥诺尔免疫有限公司 肽支架设计
CN103347892B (zh) 2011-01-06 2016-11-02 比奥诺尔免疫有限公司 单体和多聚体免疫原性肽
CA2863083C (en) * 2012-01-26 2023-09-19 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
WO2013182661A1 (en) 2012-06-06 2013-12-12 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
AU2016215049B2 (en) 2015-02-06 2021-12-02 Cell Idx, Inc. Antigen-coupled immunoreagents
ES2832335T3 (es) 2015-03-27 2021-06-10 Ortho Clinical Diagnostics Inc Polipéptidos NS4A/NS3 modificado del VHC y usos de los mismos
CN109716130B (zh) * 2016-07-18 2023-05-23 赛尔伊迪克斯公司 抗原偶联的杂交试剂
KR101813586B1 (ko) * 2016-12-29 2018-01-30 고려대학교 산학협력단 다양한 질병마커 인지 에피토프와 연결된 단백질 나노입자 및 이를 이용한 고민감도 질병마커 검출방법
EP3658171B1 (en) * 2017-07-27 2023-08-30 Roche Diagnostics GmbH Multi-epitope fusion protein of an hcv antigen and uses thereof
KR101871985B1 (ko) * 2017-08-14 2018-06-27 고려대학교 산학협력단 3차원 단백질 나노입자 프로브 기반 복수 질환의 동시검출 방법 및 키트
CN108794636B (zh) * 2018-06-28 2020-05-22 中国人民解放军军事科学院军事医学研究院 一种表位多肽串联混合物在抗立氏立克次体的免疫保护中的应用
KR102100813B1 (ko) * 2018-11-08 2020-04-16 주식회사 보레다바이오텍 C형 간염바이러스 유래 융합 단백질 및 이를 포함하는 진단키트

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69232871T2 (de) * 1991-06-24 2003-05-08 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Polypeptide des hepatitis c-virus (hiv)
ES2300100T3 (es) * 1991-10-16 2008-06-01 Merck Patent Gmbh Metodos para el diseño de peptidos de epitodo recombinado.
US5683695A (en) * 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5744144A (en) * 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
GB2294047A (en) * 1994-10-14 1996-04-17 Merck & Co Inc Synthetic peptides for use as epitopes specific for HIV

Also Published As

Publication number Publication date
IL126460A0 (en) 1999-08-17
AU3214397A (en) 1997-12-09
AU719929B2 (en) 2000-05-18
JP3945822B2 (ja) 2007-07-18
JP2007127671A (ja) 2007-05-24
WO1997044469A2 (en) 1997-11-27
DE69734776D1 (de) 2006-02-09
EP0935662B1 (en) 2005-11-30
CA2250723A1 (en) 1997-11-27
ES2251028T3 (es) 2006-04-16
CA2250723C (en) 2012-07-17
NZ333431A (en) 2000-05-26
EP0935662A2 (en) 1999-08-18
DK0935662T3 (da) 2006-03-06
IL126460A (en) 2007-07-04
JP2001500723A (ja) 2001-01-23
DE69734776T2 (de) 2006-08-17
WO1997044469A8 (en) 1999-07-22
WO1997044469A3 (en) 1997-12-31

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