ATE308549T1 - Herstellung von n-geschützten-3-pyrrolidin-lactam substituierten phosphonium salzen - Google Patents
Herstellung von n-geschützten-3-pyrrolidin-lactam substituierten phosphonium salzenInfo
- Publication number
- ATE308549T1 ATE308549T1 AT01969573T AT01969573T ATE308549T1 AT E308549 T1 ATE308549 T1 AT E308549T1 AT 01969573 T AT01969573 T AT 01969573T AT 01969573 T AT01969573 T AT 01969573T AT E308549 T1 ATE308549 T1 AT E308549T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidine
- protected
- preparation
- phosphonium salts
- substituted phosphonium
- Prior art date
Links
- 150000004714 phosphonium salts Chemical class 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117525 | 2000-08-14 | ||
| PCT/EP2001/009059 WO2002014332A1 (en) | 2000-08-14 | 2001-08-06 | Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308549T1 true ATE308549T1 (de) | 2005-11-15 |
Family
ID=8169526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01969573T ATE308549T1 (de) | 2000-08-14 | 2001-08-06 | Herstellung von n-geschützten-3-pyrrolidin-lactam substituierten phosphonium salzen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6828442B2 (de) |
| EP (1) | EP1311518B1 (de) |
| JP (1) | JP3989832B2 (de) |
| KR (1) | KR100698814B1 (de) |
| CN (1) | CN1212327C (de) |
| AT (1) | ATE308549T1 (de) |
| AU (1) | AU2001289789A1 (de) |
| CA (1) | CA2418970C (de) |
| DE (1) | DE60114641T2 (de) |
| DK (1) | DK1311518T3 (de) |
| ES (1) | ES2251508T3 (de) |
| MX (1) | MXPA03001310A (de) |
| WO (1) | WO2002014332A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002014332A1 (en) * | 2000-08-14 | 2002-02-21 | Basilea Pharmaceutica Ag | Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts |
| JP2002212155A (ja) * | 2001-01-17 | 2002-07-31 | Toray Ind Inc | 光学活性アスパラギンエステル誘導体、光学活性３−アミノピロリジン−２，５−ジオン誘導体および光学活性３−アミノピロリジン誘導体の製造方法 |
| KR20120016662A (ko) | 2009-05-25 | 2012-02-24 | 산도즈 아게 | 세프토비프롤 메도카릴의 제조 방법 |
| CN111471058A (zh) * | 2019-01-23 | 2020-07-31 | 中国医学科学院药物研究所 | 用于制备头孢吡普类似物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804577A (en) * | 1995-09-12 | 1998-09-08 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
| TW415949B (en) * | 1996-12-19 | 2000-12-21 | Hoffmann La Roche | Vinyl pyrrolidine cephalosporin derivatives with basic substituents |
| WO2002014332A1 (en) * | 2000-08-14 | 2002-02-21 | Basilea Pharmaceutica Ag | Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts |
-
2001
- 2001-08-06 WO PCT/EP2001/009059 patent/WO2002014332A1/en active IP Right Grant
- 2001-08-06 US US10/344,903 patent/US6828442B2/en not_active Expired - Fee Related
- 2001-08-06 EP EP01969573A patent/EP1311518B1/de not_active Expired - Lifetime
- 2001-08-06 CA CA2418970A patent/CA2418970C/en not_active Expired - Fee Related
- 2001-08-06 ES ES01969573T patent/ES2251508T3/es not_active Expired - Lifetime
- 2001-08-06 DK DK01969573T patent/DK1311518T3/da active
- 2001-08-06 AT AT01969573T patent/ATE308549T1/de active
- 2001-08-06 JP JP2002519470A patent/JP3989832B2/ja not_active Expired - Fee Related
- 2001-08-06 AU AU2001289789A patent/AU2001289789A1/en not_active Abandoned
- 2001-08-06 MX MXPA03001310A patent/MXPA03001310A/es active IP Right Grant
- 2001-08-06 DE DE60114641T patent/DE60114641T2/de not_active Expired - Lifetime
- 2001-08-06 KR KR1020037002100A patent/KR100698814B1/ko not_active IP Right Cessation
- 2001-08-06 CN CNB018141692A patent/CN1212327C/zh not_active Expired - Fee Related
-
2004
- 2004-08-12 US US10/916,954 patent/US7262307B2/en not_active Expired - Fee Related
-
2007
- 2007-07-26 US US11/881,487 patent/US7511154B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001289789A1 (en) | 2002-02-25 |
| DE60114641D1 (de) | 2005-12-08 |
| US7262307B2 (en) | 2007-08-28 |
| EP1311518A1 (de) | 2003-05-21 |
| US6828442B2 (en) | 2004-12-07 |
| CN1451012A (zh) | 2003-10-22 |
| EP1311518B1 (de) | 2005-11-02 |
| JP3989832B2 (ja) | 2007-10-10 |
| KR100698814B1 (ko) | 2007-03-23 |
| DE60114641T2 (de) | 2006-07-20 |
| US20030195364A1 (en) | 2003-10-16 |
| KR20030022395A (ko) | 2003-03-15 |
| CN1212327C (zh) | 2005-07-27 |
| CA2418970C (en) | 2011-03-22 |
| US20050070722A1 (en) | 2005-03-31 |
| MXPA03001310A (es) | 2003-06-30 |
| ES2251508T3 (es) | 2006-05-01 |
| JP2004506642A (ja) | 2004-03-04 |
| DK1311518T3 (da) | 2006-02-13 |
| US20080009637A1 (en) | 2008-01-10 |
| WO2002014332A1 (en) | 2002-02-21 |
| US7511154B2 (en) | 2009-03-31 |
| CA2418970A1 (en) | 2002-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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