ATE307809T1 - Neuartige pyrimidin-derivate und verfahren zu ihrer herstellung - Google Patents
Neuartige pyrimidin-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE307809T1 ATE307809T1 AT99954472T AT99954472T ATE307809T1 AT E307809 T1 ATE307809 T1 AT E307809T1 AT 99954472 T AT99954472 T AT 99954472T AT 99954472 T AT99954472 T AT 99954472T AT E307809 T1 ATE307809 T1 AT E307809T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidine derivatives
- production
- novel pyrimidine
- novel
- possess
- Prior art date
Links
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019980049164A KR100272471B1 (ko) | 1998-11-17 | 1998-11-17 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| PCT/KR1999/000669 WO2000029403A1 (en) | 1998-11-17 | 1999-11-09 | Novel pyrimidine derivatives and processes for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307809T1 true ATE307809T1 (de) | 2005-11-15 |
Family
ID=36201265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954472T ATE307809T1 (de) | 1998-11-17 | 1999-11-09 | Neuartige pyrimidin-derivate und verfahren zu ihrer herstellung |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6545008B1 (de) |
| EP (1) | EP1131312B1 (de) |
| JP (1) | JP2002530280A (de) |
| KR (1) | KR100272471B1 (de) |
| CN (1) | CN1159312C (de) |
| AT (1) | ATE307809T1 (de) |
| AU (1) | AU762098B2 (de) |
| BR (1) | BR9915323A (de) |
| CA (1) | CA2351644A1 (de) |
| DE (1) | DE69927997T2 (de) |
| ES (1) | ES2251234T3 (de) |
| HK (1) | HK1041000B (de) |
| HU (1) | HUP0104533A3 (de) |
| MX (1) | MXPA01004457A (de) |
| RU (1) | RU2236407C2 (de) |
| TR (1) | TR200101388T2 (de) |
| WO (1) | WO2000029403A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110338D0 (en) * | 2001-04-27 | 2001-06-20 | Sb Pharmco Inc | Novel processes |
| US20070161637A1 (en) * | 2003-07-22 | 2007-07-12 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| AU2004285394B2 (en) | 2003-11-03 | 2009-01-08 | Astrazeneca Ab | Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux |
| JP5335426B2 (ja) * | 2005-09-27 | 2013-11-06 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ジアリールアミン含有化合物および組成物、ならびにｃ−ｋｉｔ受容体のモジュレーターとしてのそれらの使用 |
| RU2586276C2 (ru) | 2009-07-09 | 2016-06-10 | Раквалиа Фарма Инк. | Антагонист кислотного насоса для лечения заболеваний, связанных с патологическим нарушением моторики желудочно-кишечного тракта |
| SG10201600149VA (en) | 2012-11-21 | 2016-02-26 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| WO2015030847A1 (en) * | 2013-08-30 | 2015-03-05 | Ptc Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| CA3109386A1 (en) | 2018-08-17 | 2020-03-19 | Ptc Therapeutics, Inc. | Use of 5-fluoro-2-(6-fluoro-2-methyl-1h-benzo(d)imidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine in the treatment of pancreatic cancer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980781A (en) | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
| US4000138A (en) | 1966-03-31 | 1976-12-28 | Imperial Chemical Industries Limited | Organic compounds and compositions containing them |
| GB1182584A (en) | 1966-03-31 | 1970-02-25 | Ici Ltd | Pyrimidine derivates and the use thereof as fungicides |
| US4044136A (en) | 1972-09-09 | 1977-08-23 | Pfizer Inc. | Aminoquinazoline therapeutic agents |
| GB1383409A (en) | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
| US3956495A (en) | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
| US4755218A (en) | 1985-12-31 | 1988-07-05 | Monsanto Company | Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes |
| US4966622A (en) | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
| FR2640582B1 (fr) | 1988-12-21 | 1991-08-16 | Gerard Megret | Procede d'habillage d'elements de boites montees et installation pour la mise en oeuvre de ce procede |
| ES2081863T3 (es) | 1989-03-22 | 1996-03-16 | Ciba Geigy Ag | Plaguicidas. |
| GB8910722D0 (en) | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
| GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| DK0556310T3 (da) | 1990-11-06 | 1995-08-21 | Pfizer | Quinazolinderivater til forhøjelse af antitumoraktivitet |
| AU653601B2 (en) | 1991-04-17 | 1994-10-06 | Pfizer Inc. | Pyrimidine derivatives for enhancing antitumor activity |
| US5276186A (en) | 1992-03-11 | 1994-01-04 | Ciba-Geigy Corporation | Process for the production of guanidine derivatives |
| KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| ES2114662T3 (es) | 1993-08-26 | 1998-06-01 | Ono Pharmaceutical Co | Derivados de la 4-aminopirimidina. |
| WO1995010506A1 (en) | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
| DE69530989T2 (de) * | 1994-08-13 | 2004-05-19 | Yuhan Corp. | Neue pyrimidinderivate und verfahren zu ihrer herstellung |
| DE69706981T2 (de) * | 1996-05-04 | 2002-06-06 | Yuhan Corp., Seoul/Soul | Verfahren zur herstellung von pyrimidin-derivaten |
| BR9712392A (pt) * | 1996-10-29 | 2000-01-25 | Yuhan Corp | Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina |
| IN188411B (de) | 1997-03-27 | 2002-09-21 | Yuhan Corp |
-
1998
- 1998-11-17 KR KR1019980049164A patent/KR100272471B1/ko not_active Expired - Fee Related
-
1999
- 1999-11-09 RU RU2001116601/04A patent/RU2236407C2/ru not_active IP Right Cessation
- 1999-11-09 ES ES99954472T patent/ES2251234T3/es not_active Expired - Lifetime
- 1999-11-09 AU AU10812/00A patent/AU762098B2/en not_active Ceased
- 1999-11-09 BR BR9915323-8A patent/BR9915323A/pt not_active IP Right Cessation
- 1999-11-09 CN CNB998133663A patent/CN1159312C/zh not_active Expired - Fee Related
- 1999-11-09 CA CA002351644A patent/CA2351644A1/en not_active Abandoned
- 1999-11-09 HU HU0104533A patent/HUP0104533A3/hu unknown
- 1999-11-09 TR TR2001/01388T patent/TR200101388T2/xx unknown
- 1999-11-09 DE DE69927997T patent/DE69927997T2/de not_active Expired - Fee Related
- 1999-11-09 WO PCT/KR1999/000669 patent/WO2000029403A1/en not_active Ceased
- 1999-11-09 MX MXPA01004457A patent/MXPA01004457A/es not_active IP Right Cessation
- 1999-11-09 EP EP99954472A patent/EP1131312B1/de not_active Expired - Lifetime
- 1999-11-09 AT AT99954472T patent/ATE307809T1/de not_active IP Right Cessation
- 1999-11-09 HK HK02102766.6A patent/HK1041000B/zh not_active IP Right Cessation
- 1999-11-09 JP JP2000582390A patent/JP2002530280A/ja not_active Ceased
- 1999-11-09 US US09/856,048 patent/US6545008B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000029403A1 (en) | 2000-05-25 |
| BR9915323A (pt) | 2001-08-07 |
| KR100272471B1 (ko) | 2000-11-15 |
| TR200101388T2 (tr) | 2001-10-22 |
| JP2002530280A (ja) | 2002-09-17 |
| DE69927997D1 (de) | 2005-12-01 |
| AU762098B2 (en) | 2003-06-19 |
| AU1081200A (en) | 2000-06-05 |
| MXPA01004457A (es) | 2004-04-05 |
| ES2251234T3 (es) | 2006-04-16 |
| EP1131312B1 (de) | 2005-10-26 |
| KR20000032633A (ko) | 2000-06-15 |
| HK1041000A1 (en) | 2002-06-28 |
| CN1159312C (zh) | 2004-07-28 |
| CA2351644A1 (en) | 2000-05-25 |
| HUP0104533A3 (en) | 2003-01-28 |
| HK1041000B (zh) | 2004-12-31 |
| EP1131312A1 (de) | 2001-09-12 |
| HUP0104533A2 (hu) | 2002-04-29 |
| RU2236407C2 (ru) | 2004-09-20 |
| US6545008B1 (en) | 2003-04-08 |
| CN1326453A (zh) | 2001-12-12 |
| DE69927997T2 (de) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |