ATE303994T1 - Verbindungen für ceramid-vermittelter signalübertragung - Google Patents
Verbindungen für ceramid-vermittelter signalübertragungInfo
- Publication number
- ATE303994T1 ATE303994T1 AT01129223T AT01129223T ATE303994T1 AT E303994 T1 ATE303994 T1 AT E303994T1 AT 01129223 T AT01129223 T AT 01129223T AT 01129223 T AT01129223 T AT 01129223T AT E303994 T1 ATE303994 T1 AT E303994T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- inhibit
- ceramide
- vivo
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Earth Drilling (AREA)
- Communication Control (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36710294A | 1994-12-29 | 1994-12-29 | |
| US08/482,551 US5843943A (en) | 1994-12-29 | 1995-06-07 | Compounds for inhibition of ceramide-mediated signal transduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303994T1 true ATE303994T1 (de) | 2005-09-15 |
Family
ID=23445942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95944144T ATE220549T1 (de) | 1994-12-29 | 1995-12-18 | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
| AT01129223T ATE303994T1 (de) | 1994-12-29 | 1995-12-18 | Verbindungen für ceramid-vermittelter signalübertragung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95944144T ATE220549T1 (de) | 1994-12-29 | 1995-12-18 | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0801568B1 (de) |
| JP (1) | JPH11502193A (de) |
| AT (2) | ATE220549T1 (de) |
| AU (1) | AU717243B2 (de) |
| CA (1) | CA2208580A1 (de) |
| DE (2) | DE69527438T2 (de) |
| WO (1) | WO1996020710A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323201B1 (en) * | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
| DE19540798A1 (de) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel |
| US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
| US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
| US6649362B2 (en) | 1997-09-08 | 2003-11-18 | Medvet Science Pty. Ltd. | Screening method for an agent having an effect on a sphingosine kinase signaling pathway |
| AUPO900297A0 (en) * | 1997-09-08 | 1997-10-02 | Medvet Science Pty. Ltd. | A method of modulating cellular activity |
| EP1091960A1 (de) * | 1998-06-29 | 2001-04-18 | The Regents Of The University Of California | Aktivierungskaskaden-bifunktionelle antagonisten von cytokin-empfindlichen protein-kinasen und verfahren zur verwendung als entzündungshemmende mittel |
| WO2000045800A2 (en) * | 1999-02-02 | 2000-08-10 | K.U. Leuven Research & Development | Immunosurpressive effects of pteridine derivatives |
| US6946465B2 (en) | 1999-02-02 | 2005-09-20 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
| IT1307786B1 (it) | 1999-07-22 | 2001-11-19 | Bracco Spa | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. |
| WO2002024711A1 (fr) * | 2000-09-20 | 2002-03-28 | Nikken Chemicals Co., Ltd. | Nouveaux composes bicycliques thiazole |
| WO2008009079A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| CA2661553A1 (en) * | 2006-08-23 | 2008-02-28 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Method of treating or preventing oxidative stress-related disease |
| JP5390407B2 (ja) * | 2007-03-06 | 2014-01-15 | ノバルティス アーゲー | 炎症またはアレルギー症状の処置に適する二環式有機化合物 |
| HUE050029T2 (hu) | 2015-03-04 | 2020-11-30 | Gilead Sciences Inc | 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként |
| US10278973B2 (en) * | 2015-05-20 | 2019-05-07 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| JP6746776B2 (ja) | 2016-09-02 | 2020-08-26 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｏｌｌ様受容体調節剤化合物 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992021344A2 (en) * | 1991-05-24 | 1992-12-10 | Fred Hutchinson Cancer Research Center | Modulation of cellular response to external stimuli |
| US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
| US5366978A (en) * | 1993-11-03 | 1994-11-22 | Mk Medical Ltd. | Treatment for Kawasaki disease |
-
1995
- 1995-12-18 DE DE69527438T patent/DE69527438T2/de not_active Expired - Fee Related
- 1995-12-18 JP JP8521051A patent/JPH11502193A/ja active Pending
- 1995-12-18 AT AT95944144T patent/ATE220549T1/de not_active IP Right Cessation
- 1995-12-18 AT AT01129223T patent/ATE303994T1/de not_active IP Right Cessation
- 1995-12-18 CA CA002208580A patent/CA2208580A1/en not_active Abandoned
- 1995-12-18 DE DE69534438T patent/DE69534438T2/de not_active Expired - Fee Related
- 1995-12-18 EP EP95944144A patent/EP0801568B1/de not_active Expired - Lifetime
- 1995-12-18 AU AU46019/96A patent/AU717243B2/en not_active Ceased
- 1995-12-18 WO PCT/US1995/016521 patent/WO1996020710A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69527438T2 (de) | 2003-03-06 |
| ATE220549T1 (de) | 2002-08-15 |
| EP0801568A1 (de) | 1997-10-22 |
| EP0801568A4 (de) | 1998-02-25 |
| DE69527438D1 (de) | 2002-08-22 |
| AU717243B2 (en) | 2000-03-23 |
| DE69534438D1 (de) | 2005-10-13 |
| WO1996020710A1 (en) | 1996-07-11 |
| CA2208580A1 (en) | 1996-07-11 |
| AU4601996A (en) | 1996-07-24 |
| DE69534438T2 (de) | 2006-06-29 |
| JPH11502193A (ja) | 1999-02-23 |
| EP0801568B1 (de) | 2002-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69830995D1 (de) | Verbindungen zur hemmung der ceramid-vermittelten signalübertragung | |
| ATE303994T1 (de) | Verbindungen für ceramid-vermittelter signalübertragung | |
| EP1193257A3 (de) | Verbindungen für Ceramid-vermittelter Signalübertragung | |
| DK1165558T3 (da) | Pyrimido[6,1-a]isoquinolin-4-on-derivater | |
| TR199802282T2 (xx) | Karbolin t�revleri. | |
| DE69533551D1 (de) | Camptothecin arzneimittelkombinationen mit verringerten nebenwirkungen | |
| ES2138622T3 (es) | Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. | |
| BG105561A (en) | Phenylphenanthridines with pde-iv inhibiting activity | |
| MY121389A (en) | Imidazo pyridine derivatives which inhibit gastric acid secretion | |
| MY121294A (en) | Novel hexanoic acid derivatives. | |
| YU19499A (sh) | Benzonaftiridini kao bronhijalni terapeutici | |
| AU2904300A (en) | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity | |
| SE9401197D0 (sv) | Active compounds | |
| PT1147103E (pt) | Fenantridina-n-oxidos com actividade inibitoria de pde-iv | |
| DK1109810T3 (da) | Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet | |
| NZ505724A (en) | Dihydroxyhexanoic acid derivatives and their pharmaceutical use | |
| SI1147088T1 (sl) | 6-arilfenantridini s PDE-IV inhibirajoco aktivnostjo | |
| AU2107700A (en) | Phenanthridine-n-oxides with pde-iv inhibiting activity | |
| TR200102481T2 (tr) | Fazlı zincir muadili içeren 2-aminopiridinler. | |
| ES2054904T3 (es) | Procedimiento para la preparacion de peptidos con actividad inhibidora de sistemas enzimaticos. | |
| HK1045497A1 (en) | Vitamin d analogues and their pharmaceutical use. | |
| DK1196598T3 (da) | DSP-3 phosphatase med dobbelt specificitet | |
| WO2002076397A3 (en) | Telomerase inhibitors and methods of their use | |
| DE69735722D1 (de) | D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen | |
| NZ331374A (en) | Phenanthridine compounds and pharmaceutical compositions thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |